{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T02:51:34Z","timestamp":1774493494358,"version":"3.50.1"},"reference-count":33,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["International Orthodontics"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.ortho.2024.100869","type":"journal-article","created":{"date-parts":[[2024,3,20]],"date-time":"2024-03-20T23:01:38Z","timestamp":1710975698000},"page":"100869","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients"],"prefix":"10.1016","volume":"22","author":[{"given":"Jyoti","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Payal","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Devicharan","family":"Shetty","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Piush","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5606-372X","authenticated-orcid":false,"given":"Shubhangi","family":"Jain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Varun","family":"Suroliya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prince","family":"Garg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0170","doi-asserted-by":"crossref","first-page":"3","DOI":"10.2319\/02016-101.1","article-title":"Orthodontically induced external apical root resorption in patients treated with fixed appliances vs. removable aligners","volume":"87","author":"Linares","year":"2016","journal-title":"Angle Orthod"},{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0175","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/0889-5406(93)70106-X","article-title":"Root resorption after orthodontic treatment. Part 1. Literature review","volume":"103","author":"Brezniak","year":"1993","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"10.1016\/j.ortho.2024.100869_bib0180","doi-asserted-by":"crossref","DOI":"10.1590\/S2176-94512012000200008","article-title":"Risk variables of external apical root resorption during orthodontic treatment","volume":"17","author":"Barroso","year":"2012","journal-title":"Dental Press J Orthod"},{"key":"10.1016\/j.ortho.2024.100869_bib0185","series-title":"Orthodontic current principals and techniques","author":"Graber","year":"2017"},{"issue":"4","key":"10.1016\/j.ortho.2024.100869_bib0190","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ajodo.2007.10.051","article-title":"Association of functional gene polymorphism IL-1b in patients with external apical root resorption","volume":"136","author":"Lages","year":"2009","journal-title":"Am J Orthod Dentofac Orthop"},{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0195","doi-asserted-by":"crossref","first-page":"2038","DOI":"10.1007\/s00056-009-8808-6","article-title":"Interleukin-1 polymorphisms in relation to external apical root resorption (EARR)","volume":"70","author":"Gulden","year":"2009","journal-title":"J Orofac Orthop"},{"issue":"2","key":"10.1016\/j.ortho.2024.100869_bib0200","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.ajodo.2015.12.028","article-title":"Genetic and clinical risk factors of root resorption associated with orthodontic treatment","volume":"150","author":"Guo","year":"2016","journal-title":"Am J Orthod Dentofac Orthop"},{"key":"10.1016\/j.ortho.2024.100869_bib0205","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1067\/mod.2003.42","article-title":"Genetic predisposition to external apical root resorption in","volume":"123","author":"Al-Qawasmi","year":"2003","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"4","key":"10.1016\/j.ortho.2024.100869_bib0210","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1016\/j.ajodo.2007.10.051","article-title":"Association of functional gene polymorphism IL-1\u03b2in patients with external apical root resorption","volume":"136","author":"Bastos Lages","year":"2009","journal-title":"Am J Orthod Dentofacial Orthop"},{"key":"10.1016\/j.ortho.2024.100869_bib0215","doi-asserted-by":"crossref","first-page":"e29524","DOI":"10.1371\/journal.pone.0029524","article-title":"Functional polymorphism of IL-1 alpha and its potential role in obesity in humans and mice","volume":"6","author":"Um","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.ortho.2024.100869_bib0220","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.odw.2009.05.002","article-title":"External apical root resorption and the interleukin-1B gene polymorphism in the Japanese population","volume":"68","author":"Tomoyasu","year":"2009","journal-title":"Orthod Waves"},{"key":"10.1016\/j.ortho.2024.100869_bib0225","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1177\/0022034516677539","article-title":"Cellular and molecular pathways leading to external root resorption","volume":"96","author":"Iglesias-Linares","year":"2017","journal-title":"J Dent Res"},{"key":"10.1016\/j.ortho.2024.100869_bib0230","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.joen.2011.12.022","article-title":"Post orthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism","volume":"38","author":"Iglesias-Linares","year":"2012","journal-title":"J Endod"},{"issue":"3","key":"10.1016\/j.ortho.2024.100869_bib0235","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1601-0825.2012.01973.x","article-title":"IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia","volume":"19","author":"Linhartova","year":"2012","journal-title":"Oral Dis"},{"issue":"4","key":"10.1016\/j.ortho.2024.100869_bib0240","doi-asserted-by":"crossref","first-page":"4678","DOI":"10.4238\/2013.October.18.6","article-title":"Interleukin-1\u03b2 +3954 polymorphisms and risk of external apical root resorption in orthodontic treatment: a meta-analysis","volume":"12","author":"Wu","year":"2013","journal-title":"Genet Mol Res"},{"key":"10.1016\/j.ortho.2024.100869_bib0245","doi-asserted-by":"crossref","first-page":"100711","DOI":"10.1016\/j.mgene.2020.100711","article-title":"The rs1143634 of IL-1\u03b2 gene is associated with external apical root resorption in Iranian population","volume":"24","author":"Behnaz","year":"2020","journal-title":"Meta Gene"},{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0250","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0889-5406(05)81678-6","article-title":"Patient characteristics and treatment variables associated with apical root resorption during orthodontic treatment","volume":"99","author":"Linge","year":"1991","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"6","key":"10.1016\/j.ortho.2024.100869_bib0255","first-page":"786","article-title":"A comparison of three methods to accurately measure root length","volume":"74","author":"Brezniak","year":"2004","journal-title":"Angle Orthod"},{"issue":"10","key":"10.1016\/j.ortho.2024.100869_bib0260","doi-asserted-by":"crossref","first-page":"5613","DOI":"10.1007\/s00784-021-04074-5","article-title":"Genetic variation involved in the risk to external apical root resorption in orthodontic patients: a systematic review","volume":"25","author":"Pinheiro","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.ortho.2024.100869_bib0265","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1111\/j.1601-0825.2011.01865.x","article-title":"Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations","volume":"18","author":"Iglesias-Linares","year":"2012","journal-title":"Oral Dis"},{"issue":"3","key":"10.1016\/j.ortho.2024.100869_bib0270","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1111\/j.1601-0825.2012.01973.x","article-title":"IL1 gene polymorphisms in relation to external apical root resorption concurrent with orthodontia","volume":"19","author":"Linhartova","year":"2013","journal-title":"Oral Dis"},{"key":"10.1016\/j.ortho.2024.100869_bib0275","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1111\/ocr.12078","article-title":"Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia","volume":"18","author":"Sharab","year":"2015","journal-title":"Orthod Craniofac Res"},{"issue":"7","key":"10.1016\/j.ortho.2024.100869_bib0280","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1111\/odi.12185","article-title":"Polymorphisms of genes encoding P2X7R, IL-1B, OPG and RANK in orthodontic-induced apical root resorption","volume":"20","author":"Pereira","year":"2013","journal-title":"Oral Dis"},{"issue":"7","key":"10.1016\/j.ortho.2024.100869_bib0285","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/odi.12514","article-title":"IRAK1 variant is protective for orthodontic-induced external apical root resorption","volume":"22","author":"Pereira","year":"2016","journal-title":"Oral Dis"},{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0290","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1186\/s12903-022-02306-y","article-title":"Influence of clinical factors on the protective or deleterious impact of genetic variants in orthodontically induced external root resorption: an observational study","volume":"22","author":"Silva","year":"2022","journal-title":"BMC Oral Health"},{"issue":"2","key":"10.1016\/j.ortho.2024.100869_bib0295","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2319\/050512-372.1","article-title":"Comparison of cone-beam computed tomography and periapical radiography for detecting simulated apical root resorption","volume":"83","author":"Ren","year":"2013","journal-title":"Angle Orthod"},{"issue":"3","key":"10.1016\/j.ortho.2024.100869_bib0300","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1093\/ejo\/cjp106","article-title":"Emotional stress and orthodontic tooth movement: effects on apical root resorption, tooth movement, and dental tissue expression of interleukin-1 alpha and calcitonin gene-related peptide immunoreactive nerve fibers in rats","volume":"32","author":"Vandevska-Radunovic","year":"2010","journal-title":"Eur J Orthod"},{"issue":"5","key":"10.1016\/j.ortho.2024.100869_bib0305","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1016\/j.ajodo.2006.03.043","article-title":"increases production of proinflammatory cytokines and formation of osteoclasts in dental pulp fibroblasts in patients with severe orthodontic root resorption","volume":"133","author":"Yamaguchi","year":"2008","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"2","key":"10.1016\/j.ortho.2024.100869_bib0310","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.ajodo.2015.03.023","article-title":"Interleukin-17 is involved in orthodontically induced inflammatory root resorption in dental pulp cells","volume":"148","author":"Nakano","year":"2015","journal-title":"Am J Orthod Dentofacial Orthop"},{"issue":"1","key":"10.1016\/j.ortho.2024.100869_bib0315","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s40510-017-0177-x","article-title":"A preliminary investigation of short-term cytokine expression in gingival crevicular fluid secondary to high-level orthodontic forces and the associated root resorption: case series analytical study","volume":"18","author":"Ahuja","year":"2017","journal-title":"Prog Orthod"},{"issue":"9","key":"10.1016\/j.ortho.2024.100869_bib0320","first-page":"8","article-title":"Amplification-refractory mutation system (ARMS) analysis of point mutations","volume":"9","author":"Little","year":"2001","journal-title":"Curr Protoc Hum Genet"},{"key":"10.1016\/j.ortho.2024.100869_bib0325","first-page":"66","article-title":"A clinical risk prediction model of orthodontic-induced external apical root resorption","volume":"55","author":"Pereira","year":"2014","journal-title":"Rev Port Estomatol Med Dent Cir Maxilofac"},{"key":"10.1016\/j.ortho.2024.100869_bib0330","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1177\/154405910308200506","article-title":"Genetic predisposition to external apical root resorption in orthodontic patients: linkage of chromosome-18 marker","volume":"82","author":"Al-Qawasmi","year":"2003","journal-title":"J Dent Res"}],"container-title":["International Orthodontics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1761722724000251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1761722724000251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T11:22:05Z","timestamp":1715858525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1761722724000251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":33,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6]]}},"alternative-id":["S1761722724000251"],"URL":"https:\/\/doi.org\/10.1016\/j.ortho.2024.100869","relation":{},"ISSN":["1761-7227"],"issn-type":[{"value":"1761-7227","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Association of genetic polymorphism of interleukin 1-alpha and interleukin 1-beta with external apical root resorption in orthodontic patients","name":"articletitle","label":"Article Title"},{"value":"International Orthodontics","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.ortho.2024.100869","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 CEO. Published by Elsevier Masson SAS. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"100869"}}