{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:48:57Z","timestamp":1757702937253},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":610,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The growth\/differentiation factors (GDFs) are a subgroup of the bone morphogenetic proteins best known for their role in joint formation and chondrogenesis. Mice deficient in one of these signaling proteins, GDF\u20105, exhibit numerous skeletal abnormalities, including shortened limb bones. The primary aim of this study was determine whether GDF\u20105 deficiency would alter the growth rate in growth plates from the long bones in mice and, if so, how this is achieved. Stereologic and cell kinetic parameters in proximal tibial growth plates from 5\u2010week\u2010old female GDF\u20105 \u2010\/\u2010 mice and control littermates were examined. GDF\u20105 deficiency resulted in a statistically significant reduction in growth rate (\u221214%, <jats:italic>p<\/jats:italic> = 0.03). The effect of genotype on growth rate was associated with an altered hypertrophic phase duration, with hypertrophic cells from GDF\u20105 deficient mice exhibiting a significantly longer phase duration compared to control littermates (+25%, <jats:italic>p<\/jats:italic> = 0.006). These data suggest that one way in which GDF\u20105 might modulate the rate of endochondral bone growth could be by affecting the duration of the hypertrophic phase in growth plate chondrocytes. \u00a9 2003 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/j.orthres.2003.09.002","type":"journal-article","created":{"date-parts":[[2003,10,25]],"date-time":"2003-10-25T19:41:29Z","timestamp":1067110889000},"page":"552-556","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Altered hypertrophic chondrocyte kinetics in GDF\u20105 deficient murine tibial growth plates"],"prefix":"10.1002","volume":"22","author":[{"given":"B.","family":"Mikic","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. T.","family":"Clark","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. 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