{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T19:30:32Z","timestamp":1791660632346,"version":"4.3.4"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Background<\/jats:italic>: An in vivo animal model for carpal tunnel syndrome (CTS) is presented which allows for graded application of pressure to the median nerve within the carpal canal. We hypothesized that such pressure would cause electrophysiologic changes in the median nerve in a dose\u2010related manner, with NCS\/EMG changes consistent with CTS in humans.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: In 40 New Zealand white rabbits, ranging from 2 to 2.5 kg, angioplasty catheters were placed in the carpal tunnel in the forepaws and pressures ranging from 50 to 80 mm Hg applied to one side while the contralateral side served as the control and remained uninflated. Pressure was applied until a 15% increase in distal motor latency was obtained for 2 consecutive weeks by nerve conduction studies.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: All the experimental limbs exhibited a 15% increase in distal motor latency. None of the control limbs showed a significant increase in distal motor latency. In the experimental animals the 15% delay was achieved in approximately 4\u20135 weeks in the 50\u201370 mm Hg groups and in approximately 1 week in the 80 mm Hg group.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: This new animal model for CTS demonstrates a direct cause and effect relationship between carpal tunnel pressure and median nerve dysfunction. We anticipate that this in vivo model with clinically relevant outcomes will facilitate identification of injury mechanisms, and will serve as a basis for future development of novel interventions and treatments. \u00a9 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/j.orthres.2004.05.014","type":"journal-article","created":{"date-parts":[[2004,9,18]],"date-time":"2004-09-18T15:07:10Z","timestamp":1095520030000},"page":"218-223","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":63,"title":["Carpal tunnel pressure alters median nerve function in a dose\u2010dependent manner: A rabbit model for carpal tunnel syndrome"],"prefix":"10.1002","volume":"23","author":[{"given":"Edward","family":"Diao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen","family":"Liebenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Rempel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey C.","family":"Lotz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.282.2.153"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-194807000-00002"},{"key":"e_1_2_1_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(83)80266-4"},{"key":"e_1_2_1_5_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198062070-00020"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-198163030-00009"},{"issue":"6","key":"e_1_2_1_7_2","doi-asserted-by":"crossref","first-page":"896","DOI":"10.2106\/00004623-198769060-00016","article-title":"Results of treatment of severe carpal\u2010tunnel syndrome without internal neuro lysis of the median nerve","volume":"69","author":"Gelberman RH","year":"1987","journal-title":"J Bone Joint Surg Am"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.1564"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1985.62.3.0352"},{"key":"e_1_2_1_10_2","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00003086-198802000-00029","article-title":"Interfascicular neurolysis in the severe carpal tunnel syndrome. A prospective, randomized, double\u2010blind, controlled study","volume":"227","author":"Lowry WE","year":"1988","journal-title":"Clin Orthop"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(82)80175-5"},{"issue":"2","key":"e_1_2_1_12_2","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1302\/0301-620X.55B2.390","article-title":"Effects of stretching the tibial nerve of the rabbit. A preliminary study of the intraneural circulation and the barrier function of the perineurium","volume":"55","author":"Lundborg G","year":"1973","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01403466"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000637-198408000-00004"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(10)80099-1"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1080\/15428119591016863"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0266-7681(88)90046-0"},{"issue":"1","key":"e_1_2_1_18_2","first-page":"91","article-title":"Pathology of experimental nerve compression","volume":"55","author":"Powell HC","year":"1986","journal-title":"Lab Invest"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199911000-00013"},{"issue":"2","key":"e_1_2_1_20_2","doi-asserted-by":"crossref","first-page":"253","DOI":"10.2106\/00004623-198567020-00011","article-title":"Results of internal neurolysis of the median nerve for severe carpal\u2010tunnel syndrome","volume":"67","author":"Rhoades CE","year":"1985","journal-title":"J Bone Joint Sur Am"},{"key":"e_1_2_1_21_2","doi-asserted-by":"publisher","DOI":"10.5271\/sjweh.233"},{"key":"e_1_2_1_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(81)80003-2"},{"key":"e_1_2_1_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0363-5023(89)80048-6"},{"key":"e_1_2_1_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajim.4700240205"},{"key":"e_1_2_1_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0363-5023(94)90054-X"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.orthres.2004.05.014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.orthres.2004.05.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T19:14:23Z","timestamp":1697138063000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.orthres.2004.05.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["10.1016\/j.orthres.2004.05.014"],"URL":"https:\/\/doi.org\/10.1016\/j.orthres.2004.05.014","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}