{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,6]],"date-time":"2026-03-06T13:28:42Z","timestamp":1772803722367,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":306,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:italic>Introduction<\/jats:italic>: Tissues subjected to prolonged ischaemia are paradoxically further damaged when their perfusion is restored. The mechanisms underlying this ischaemia\u2013reperfusion injury are complex, but oxidative attack is a central feature. Among the therapeutic agents used to attenuate ischaemia\u2013reperfusion injury, endogenous agents such as taurine which form part of the native defence mechanism against oxidative damage are of particular interest.<\/jats:p><jats:p><jats:italic>Methods<\/jats:italic>: Using a model of hindlimb ischaemia\u2013reperfusion injury in the rat, taurine solution was administered either into the operated hindlimb, into the systemic circulation, or both. Contraction strengths of gastrocnemius biopsies from the operated and contralateral (control) hindlimbs of each animal were measured.<\/jats:p><jats:p><jats:italic>Results<\/jats:italic>: Fast twitch strength was impaired significantly by ischaemia\u2013reperfusion injury, and taurine injected into the operated limb conferred partial protection. A similar trend was observed for tetany, but protection by taurine was not statistically significant for tetanic contraction strength.<\/jats:p><jats:p><jats:italic>Conclusion<\/jats:italic>: Preservation of fast twitch strength following ischaemia\u2013reperfusion injury by administration of taurine before ischaemia has clinical potential. However, delivery to the affected tissues during ischaemia presents technical difficulties. \u00a9 2004 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/j.orthres.2004.07.003","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T22:04:48Z","timestamp":1095199488000},"page":"310-314","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Effects of systemic and regional taurine on skeletal muscle function following ischaemia\u2013reperfusion injury"],"prefix":"10.1002","volume":"23","author":[{"given":"Ross","family":"Kingston","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Kearns","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cathal","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paraic","family":"Murray","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1078-5884(97)80018-4"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/ejvs.1999.0813"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0065-3101(24)00213-5","article-title":"Taurine: its biological role and clinical implications","volume":"32","author":"Chesney RW","year":"1985","journal-title":"Adv Pediatr"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1177\/096721099400200614","article-title":"Role of neutrophil depletion and elastase inhibition in modifying skeletal muscle reperfusion injury","volume":"2","author":"Crinnion JN","year":"1994","journal-title":"Cardiovasc Surg"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00726-002-0202-2"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1006\/jsre.2000.6005"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0940-2993(98)80030-4"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2828(77)80357-X"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1000152"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.83B8.11754"},{"key":"e_1_2_1_12_2","first-page":"122","article-title":"Prophylactic effects of taurine and diltiazem, alone or combined, on reperfusion arrhythmias in rats","volume":"17","author":"Li P","year":"1996","journal-title":"Zhongguo Yao Li Xue Bao"},{"key":"e_1_2_1_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/110241500750008916"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-8703(92)90644-B"},{"key":"e_1_2_1_15_2","first-page":"298","article-title":"Antioxidative vitamins in prevention of ischemia\/reperfusion injury","volume":"67","author":"Nagel E","year":"1997","journal-title":"Int J Vitam Nutr Res"},{"key":"e_1_2_1_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0261-5614(99)80073-9"},{"key":"e_1_2_1_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000129207"},{"key":"e_1_2_1_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02576213"},{"key":"e_1_2_1_19_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02975370"},{"key":"e_1_2_1_20_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-0117-0_37"}],"container-title":["Journal of Orthopaedic Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1016%2Fj.orthres.2004.07.003","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.orthres.2004.07.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,18]],"date-time":"2024-12-18T16:23:43Z","timestamp":1734539023000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.orthres.2004.07.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1016\/j.orthres.2004.07.003"],"URL":"https:\/\/doi.org\/10.1016\/j.orthres.2004.07.003","archive":["Portico"],"relation":{},"ISSN":["0736-0266","1554-527X"],"issn-type":[{"value":"0736-0266","type":"print"},{"value":"1554-527X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,3]]},"assertion":[{"value":"2004-07-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2006-01-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}