{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T01:27:49Z","timestamp":1791854869456,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":184,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Journal Orthopaedic Research"],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We hypothesized that the bisphosphonate zoledronic acid (ZA) could improve femoral head sphericity in Perthes disease by changing the balance between bone resorption and new bone formation. This study tests the effect of ZA in an established model of Perthes disease, the spontaneously hypertensive rat (SHR).<\/jats:p><jats:p>One hundred and twenty 4\u2010week old SHR rats were divided into three groups of 40: saline monthly, 0.015 mg\/kg ZA weekly, or 0.05 mg\/kg ZA monthly. At 15 weeks DXA measurements documented that femoral head BMD was increased by 18% in ZA weekly and 21% in ZA monthly compared to controls (<jats:italic>p<\/jats:italic> &lt; 0.01). Femoral head sphericity in animals with osteonecrosis was improved in ZA\u2010treatment groups (<jats:italic>p<\/jats:italic> &lt; 0.01) as measured by epiphyseal quotient (EQ). The proportion of \u201cflat\u201d heads (EQ \u00b1 0.40) was significantly reduced from 32% in saline\u2010treated animals to 12% in weekly ZA and 3% in monthly ZA (<jats:italic>p<\/jats:italic> &lt; 0.01). Histologically there was a similar prevalence of osteonecrosis in all groups. The prevalence of ossification delay was significantly reduced by ZA treatment (<jats:italic>p<\/jats:italic> &lt; 0.01).<\/jats:p><jats:p>Zoledronic acid favorably altered femoral head shape in this spontaneous model of osteonecrosis in growing rats. Translation of these results to Perthes disease could mean that deformity of the femoral head may be modified in children, perhaps reducing the need for surgical intervention in childhood and adult life. \u00a9 2005 Orthopaedic Research Society. Published by Elsevier Ltd. All rights reserved.<\/jats:p>","DOI":"10.1016\/j.orthres.2004.11.015","type":"journal-article","created":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T12:45:44Z","timestamp":1109681144000},"page":"862-868","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":68,"title":["Zoledronic acid improves femoral head sphericity in a rat model of perthes disease"],"prefix":"10.1002","volume":"23","author":[{"given":"David G.","family":"Little","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"McDonald","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian T.","family":"Sharpe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"Peat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tony","family":"McEvoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,1]]},"reference":[{"key":"e_1_2_1_2_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-3-19"},{"key":"e_1_2_1_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199707000-00005"},{"key":"e_1_2_1_4_2","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1302\/0301-620X.64B3.7096391","article-title":"Perthes' disease: is the epiphysial infarction complete?","volume":"64","author":"Catterall A","year":"1982","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_1_5_2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1302\/0301-620X.64B3.6807991","article-title":"A review of the morphology of Perthes' disease","volume":"64","author":"Catterall A","year":"1982","journal-title":"J Bone Joint Surg Br"},{"key":"e_1_2_1_6_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.81B3.9405"},{"key":"e_1_2_1_7_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2002.17.6.998"},{"key":"e_1_2_1_8_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200009000-00004"},{"key":"e_1_2_1_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.287.6407.1757"},{"key":"e_1_2_1_10_2","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-199601000-00001"},{"key":"e_1_2_1_11_2","doi-asserted-by":"publisher","DOI":"10.3109\/17453678809148778"},{"key":"e_1_2_1_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02526888"},{"key":"e_1_2_1_13_2","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1097\/00003086-199204000-00005","article-title":"Idiopathic necrosis of the femoral epiphyseal nucleus in rats","volume":"277","author":"Iwasaki K","year":"1992","journal-title":"Clin Orthop"},{"key":"e_1_2_1_14_2","doi-asserted-by":"publisher","DOI":"10.1302\/0301-620X.82B2 .10033"},{"key":"e_1_2_1_15_2","doi-asserted-by":"publisher","DOI":"10.1359\/jbmr.2000.15.1.111"},{"key":"e_1_2_1_16_2","first-page":"S475","article-title":"Ibandronate decreases femoral head flattening in a piglet model of ischemic necrosis of femoral head","volume":"17","author":"Kim HKW","year":"2002","journal-title":"J Bone Miner Res"},{"key":"e_1_2_1_17_2","unstructured":"KimHKW RandallTS BianH JenkinsJ GarcesA BaussF.Ibandronate prevents femoral head deformity following ischemic necrosis of the capital femoral epiphysis in immature pigs. 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