{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:58:28Z","timestamp":1790413108216,"version":"4.1.0"},"reference-count":63,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T00:00:00Z","timestamp":1778112000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG062276"],"award-info":[{"award-number":["R01AG062276"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG066508"],"award-info":[{"award-number":["P30AG066508"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["P30AG021342"],"award-info":[{"award-number":["P30AG021342"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["K23AG057794"],"award-info":[{"award-number":["K23AG057794"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG052560"],"award-info":[{"award-number":["R01AG052560"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["AARFD-24-1306796"],"award-info":[{"award-number":["AARFD-24-1306796"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["IIRG-07-60026"],"award-info":[{"award-number":["IIRG-07-60026"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","oseponline.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice"],"published-print":{"date-parts":[[2026,9]]},"DOI":"10.1016\/j.osep.2026.04.002","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T14:48:15Z","timestamp":1778770095000},"page":"1-14","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Basal Forebrain Volume is Associated With Cortical Amyloid Burden in Cognitively Unimpaired Older Adults at Varying Genetic Risk for Alzheimer\u2019s Disease"],"prefix":"10.1016","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3512-8982","authenticated-orcid":false,"given":"Gawon","family":"Cho","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Kelly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takuya","family":"Toyonaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brienne","family":"Miner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joel","family":"Gelernter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pradeep","family":"Varma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher H.","family":"van Dyck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adam P.","family":"Mecca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryan","family":"O\u2019Dell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.osep.2026.04.002_bib0001","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann Neurol"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0002","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1006\/neur.1996.0056","article-title":"Structural correlates of cognition in dementia: quantification and assessment of synapse change","volume":"5","author":"DeKosky","year":"1996","journal-title":"Neurodegeneration"},{"issue":"5594","key":"10.1016\/j.osep.2026.04.002_bib0003","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1126\/science.1074069","article-title":"Alzheimer's disease is a synaptic failure","volume":"298","author":"Selkoe","year":"2002","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0004","doi-asserted-by":"crossref","first-page":"575","DOI":"10.3233\/JAD-161028","article-title":"Radiological-pathological correlation in Alzheimer's Disease: systematic review of antemortem magnetic resonance imaging findings","volume":"57","author":"Dallaire-Th\u00e9roux","year":"2017","journal-title":"J Alzheimers Dis"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0005","article-title":"2025 Alzheimer's disease facts and figures","volume":"21","year":"2025","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0006","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/cne.902750205","article-title":"Nucleus basalis (Ch4) and cortical cholinergic innervation in the human brain: observations based on the distribution of acetylcholinesterase and choline acetyltransferase","volume":"275","author":"Mesulam","year":"1988","journal-title":"J Compar Neurol"},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0007","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1002\/cne.902140206","article-title":"Cholinergic innervation of cortex by the basal forebrain: cytochemistry and cortical connections of the septal area, diagonal band nuclei, nucleus basalis (substantia innominata), and hypothalamus in the rhesus monkey","volume":"214","author":"Mesulam","year":"1983","journal-title":"J Compar Neurol"},{"issue":"8000","key":"10.1016\/j.osep.2026.04.002_bib0008","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1016\/S0140-6736(76)91936-X","article-title":"Selective loss of central cholinergic neurons in Alzheimer's disease","volume":"2","author":"Davies","year":"1976","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0009","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1002\/ana.410100203","article-title":"Alzheimer disease: evidence for selective loss of cholinergic neurons in the nucleus basalis","volume":"10","author":"Whitehouse","year":"1981","journal-title":"Ann Neurol."},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0306-4522(85)90160-5","article-title":"Neuronal loss in different parts of the nucleus basalis is related to neuritic plaque formation in cortical target areas in Alzheimer's disease","volume":"14","author":"Arendt","year":"1985","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0011","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/0197-4580(90)90056-6","article-title":"Cell loss and shrinkage in the nucleus basalis Meynert complex in Alzheimer's disease","volume":"11","author":"Vogels","year":"1990","journal-title":"Neurobiol Aging."},{"issue":"9","key":"10.1016\/j.osep.2026.04.002_bib0012","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1001\/archneur.56.9.1121","article-title":"Brain choline acetyltransferase and mental function in Alzheimer disease","volume":"56","author":"Baskin","year":"1999","journal-title":"Arch Neurol."},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0013","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/cne.10122","article-title":"Loss of basal forebrain P75(NTR) immunoreactivity in subjects with mild cognitive impairment and Alzheimer's disease","volume":"443","author":"Mufson","year":"2002","journal-title":"J Compar Neurol"},{"issue":"6","key":"10.1016\/j.osep.2026.04.002_bib0014","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1002\/ana.20100","article-title":"Cholinergic nucleus basalis tauopathy emerges early in the aging-MCI-AD continuum","volume":"55","author":"Mesulam","year":"2004","journal-title":"Ann Neurol"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0015","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1093\/jnen\/nlx120","article-title":"Tau oligomer pathology in nucleus basalis neurons during the progression of Alzheimer disease","volume":"77","author":"Tiernan","year":"2018","journal-title":"J Neuropathol Experiment Neurol"},{"issue":"7","key":"10.1016\/j.osep.2026.04.002_bib0016","first-page":"1685","article-title":"Reduction of basal forebrain cholinergic system parallels cognitive impairment in patients at high risk of developing Alzheimer's disease","volume":"20","author":"Grothe","year":"2010","journal-title":"Cerebral cortex (New York, NY: 1991)"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0017","doi-asserted-by":"crossref","first-page":"687","DOI":"10.3233\/JAD-132345","article-title":"Subregional basal forebrain atrophy in Alzheimer's disease: a multicenter study","volume":"40","author":"Kilimann","year":"2014","journal-title":"J Alzheimers Dis"},{"issue":"8","key":"10.1016\/j.osep.2026.04.002_bib0018","first-page":"3881","article-title":"Volume loss of the nucleus basalis of Meynert is associated with atrophy of innervated regions in mild cognitive impairment","volume":"27","author":"Cantero","year":"2017","journal-title":"Cerebral Cortex"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0019","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer's disease: recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"8","key":"10.1016\/j.osep.2026.04.002_bib0020","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0021","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.jalz.2018.02.018","article-title":"NIA-AA Research Framework: toward a biological definition of Alzheimer's disease","volume":"14","author":"Jack","year":"2018","journal-title":"Alzheimer's & dementia: the journal of the Alzheimer's Association"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0022","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13249","article-title":"Basal forebrain degeneration precedes and predicts the cortical spread of Alzheimer\u2019s pathology","volume":"7","author":"Schmitz","year":"2016","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0023","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.celrep.2018.06.001","article-title":"Alzheimer's Disease neuroimaging I. Longitudinal Alzheimer's degeneration reflects the spatial topography of cholinergic basal forebrain projections","volume":"24","author":"Schmitz","year":"2018","journal-title":"Cell Rep"},{"issue":"5","key":"10.1016\/j.osep.2026.04.002_bib0024","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.3359","article-title":"Association of brain Magnetic resonance imaging signs with cognitive outcomes in persons with nonimpaired cognition and mild cognitive impairment","volume":"2","author":"Wu","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.osep.2026.04.002_bib0025","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nicl.2014.11.015","article-title":"Basal forebrain atrophy correlates with amyloid \u03b2 burden in Alzheimer's disease","volume":"7","author":"Kerbler","year":"2015","journal-title":"Neuroimage Clin"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0026","first-page":"2083","article-title":"Atrophy of basal forebrain initiates with tau pathology in individuals at risk for Alzheimer's Disease","volume":"30","author":"Cantero","year":"2020","journal-title":"Cerebral cortex (New York, NY: 1991)"},{"issue":"7","key":"10.1016\/j.osep.2026.04.002_bib0027","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1212\/WNL.0b013e3181ee267e","article-title":"Acetylcholine in the cerebral cortex","volume":"75","author":"Benarroch","year":"2010","journal-title":"Neurology"},{"issue":"12","key":"10.1016\/j.osep.2026.04.002_bib0028","doi-asserted-by":"crossref","first-page":"1966","DOI":"10.1002\/alz.12362","article-title":"Population estimate of people with clinical Alzheimer's disease and mild cognitive impairment in the United States (2020-2060)","volume":"17","author":"Rajan","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.osep.2026.04.002_bib0029","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1038\/s41591-025-03564-3","article-title":"Women twice as likely to develop Alzheimer\u2019s disease as men \u2014 But scientists do not know why","volume":"31","author":"Moutinho","year":"2025","journal-title":"Nat Med"},{"issue":"9","key":"10.1016\/j.osep.2026.04.002_bib0030","article-title":"Influence of the onset of menopause on the risk of developing Alzheimer's Disease","volume":"16","author":"Briceno Silva","year":"2024","journal-title":"Cureus"},{"key":"10.1016\/j.osep.2026.04.002_bib0031","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neurobiolaging.2017.09.027","article-title":"Cortical \u03b2-amyloid burden, gray matter, and memory in adults at varying APOE \u03b54 risk for Alzheimer's disease","volume":"61","author":"Mecca","year":"2018","journal-title":"Neurobio Aging"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0032","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archneur.56.3.303","article-title":"Mild cognitive impairment: clinical characterization and outcome","volume":"56","author":"Petersen","year":"1999","journal-title":"Arch Neurol"},{"issue":"7","key":"10.1016\/j.osep.2026.04.002_bib0033","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1212\/WNL.34.7.939","article-title":"Clinical diagnosis of Alzheimer's disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer's Disease","volume":"34","author":"McKhann","year":"1984","journal-title":"Neurology"},{"issue":"11","key":"10.1016\/j.osep.2026.04.002_bib0034","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The clinical dementia rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0035","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1080\/01688638708405063","article-title":"Logical memory subtest of the Wechsler Memory Scale: age and education norms and alternate-form reliability of two scoring systems","volume":"9","author":"Abikoff","year":"1987","journal-title":"J Clin Exp Neuropsychol"},{"key":"10.1016\/j.osep.2026.04.002_bib0036","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\"Mini-mental state\". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0037","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1016\/j.neuroimage.2012.01.021","article-title":"FreeSurfer","volume":"62","author":"Fischl","year":"2012","journal-title":"NeuroImage"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0038","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"issue":"7","key":"10.1016\/j.osep.2026.04.002_bib0039","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1002\/alz.12097","article-title":"In vivo measurement of widespread synaptic loss in Alzheimer's disease with SV2A PET","volume":"16","author":"Mecca","year":"2020","journal-title":"Alzheimers Dement."},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0040","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1016\/j.neuroimage.2008.05.055","article-title":"Stereotaxic probabilistic maps of the magnocellular cell groups in human basal forebrain","volume":"42","author":"Zaborszky","year":"2008","journal-title":"NeuroImage"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0041","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1016\/j.neuroimage.2004.12.034","article-title":"A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data","volume":"25","author":"Eickhoff","year":"2005","journal-title":"NeuroImage"},{"issue":"12","key":"10.1016\/j.osep.2026.04.002_bib0042","doi-asserted-by":"crossref","first-page":"1440","DOI":"10.1097\/01.WCB.0000033967.83623.34","article-title":"Noise reduction in the simplified reference tissue model for neuroreceptor functional imaging","volume":"22","author":"Wu","year":"2002","journal-title":"J Cerebral Blood Flow Metab"},{"issue":"10","key":"10.1016\/j.osep.2026.04.002_bib0043","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/jamaneurol.2018.1836","article-title":"Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0044","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13195-020-00742-y","article-title":"Association of Abeta deposition and regional synaptic density in early Alzheimer's disease: a PET imaging study with [(11)C]UCB-J","volume":"13","author":"O'Dell","year":"2021","journal-title":"Alzheimers Res Ther"},{"issue":"21","key":"10.1016\/j.osep.2026.04.002_bib0045","doi-asserted-by":"crossref","DOI":"10.1088\/0031-9155\/57\/21\/R119","article-title":"A review of partial volume correction techniques for emission tomography and their applications in neurology, cardiology and oncology","volume":"57","author":"Erlandsson","year":"2012","journal-title":"Phys Med Biol"},{"issue":"7","key":"10.1016\/j.osep.2026.04.002_bib0046","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1007\/s12149-017-1185-0","article-title":"A comparison of five partial volume correction methods for tau and amyloid PET imaging with [(18)F]THK5351 and [(11)C]PIB","volume":"31","author":"Shidahara","year":"2017","journal-title":"Ann Nucl Med."},{"issue":"Pt 7","key":"10.1016\/j.osep.2026.04.002_bib0047","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1093\/brain\/awv112","article-title":"Existing Pittsburgh Compound-B positron emission tomography thresholds are too high: statistical and pathological evaluation","volume":"138","author":"Villeneuve","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.osep.2026.04.002_bib0048","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0079-6123(03)45004-8","article-title":"The cholinergic innervation of the human cerebral cortex","volume":"145","author":"Mesulam","year":"2004","journal-title":"Prog Brain Res"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0049","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/S1074-7427(03)00078-9","article-title":"Enhanced cholinergic suppression of previously strengthened synapses enables the formation of self-organized representations in olfactory cortex","volume":"80","author":"Linster","year":"2003","journal-title":"Neurobiol Learn memory"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0050","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.neuron.2012.08.036","article-title":"Acetylcholine as a neuromodulator: cholinergic signaling shapes nervous system function and behavior","volume":"76","author":"Picciotto","year":"2012","journal-title":"Neuron"},{"issue":"Pt 6","key":"10.1016\/j.osep.2026.04.002_bib0051","doi-asserted-by":"crossref","first-page":"1722","DOI":"10.1093\/brain\/awv024","article-title":"Neuronal amyloid-\u03b2 accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease","volume":"138","author":"Baker-Nigh","year":"2015","journal-title":"Brain"},{"issue":"6","key":"10.1016\/j.osep.2026.04.002_bib0052","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27061816","article-title":"Role of cholinergic signaling in Alzheimer's disease","volume":"27","author":"Chen","year":"2022","journal-title":"Molecules (Basel, Switzerland)"},{"issue":"2 Suppl 1","key":"10.1016\/j.osep.2026.04.002_bib0053","first-page":"S64","article-title":"The cholinergic hypothesis of neuropsychiatric symptoms in Alzheimer's disease. The American journal of geriatric psychiatry: official journal of the American Association for Geriatric Psychiatry","volume":"6","author":"Cummings","year":"1998","journal-title":"Spring"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0054","first-page":"404","article-title":"Revisiting the cholinergic hypothesis of behavioral and psychological symptoms in dementia of the Alzheimer's type","volume":"10","author":"Pinto","year":"2011","journal-title":"Ageing Res Rev"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0055","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00401-015-1392-5","article-title":"Nucleus basalis of Meynert revisited: anatomy, history and differential involvement in Alzheimer's and Parkinson's disease","volume":"129","author":"Liu","year":"2015","journal-title":"Acta Neuropathologica"},{"issue":"1","key":"10.1016\/j.osep.2026.04.002_bib0056","doi-asserted-by":"crossref","first-page":"425","DOI":"10.3233\/JAD-210261","article-title":"Age and anterior basal forebrain volume predict the cholinergic deficit in patients with mild cognitive impairment due to Alzheimer's Disease","volume":"86","author":"Richter","year":"2022","journal-title":"J Alzheimers Dis"},{"issue":"9","key":"10.1016\/j.osep.2026.04.002_bib0057","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.biopsych.2011.06.019","article-title":"Atrophy of the cholinergic basal forebrain over the adult age range and in early stages of Alzheimer's disease","volume":"71","author":"Grothe","year":"2012","journal-title":"Biol Psychiatry"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0058","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/j.neuron.2014.01.045","article-title":"ApoE and a\u03b2 in Alzheimer's disease: accidental encounters or partners?","volume":"81","author":"Kanekiyo","year":"2014","journal-title":"Neuron"},{"issue":"4","key":"10.1016\/j.osep.2026.04.002_bib0059","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s00401-006-0127-z","article-title":"Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry","volume":"112","author":"Braak","year":"2006","journal-title":"Acta Neuropathol"},{"key":"10.1016\/j.osep.2026.04.002_bib0060","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1196\/annals.1297.005","article-title":"The biphasic relationship between regional brain senile plaque and neurofibrillary tangle distributions: modification by age, sex, and APOE polymorphism","volume":"1019","author":"Corder","year":"2004","journal-title":"Ann NY Acad Sci"},{"issue":"10","key":"10.1016\/j.osep.2026.04.002_bib0061","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1001\/jamaneurol.2022.2967","article-title":"The ATN framework\u2014Moving preclinical Alzheimer disease to clinical relevance","volume":"79","author":"van der Flier","year":"2022","journal-title":"JAMA Neurol"},{"issue":"2","key":"10.1016\/j.osep.2026.04.002_bib0062","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.bbr.2010.11.058","article-title":"The cholinergic system in aging and neuronal degeneration","volume":"221","author":"Schliebs","year":"2011","journal-title":"Behav Brain Res"},{"issue":"3","key":"10.1016\/j.osep.2026.04.002_bib0063","first-page":"1841","article-title":"Parallel atrophy of cortex and basal forebrain cholinergic system in mild cognitive impairment","volume":"27","author":"Kilimann","year":"2017","journal-title":"Cerebral cortex (New York, NY: 1991)"}],"container-title":["The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950386826000195?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2950386826000195?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:08:29Z","timestamp":1790410109000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2950386826000195"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9]]},"references-count":63,"alternative-id":["S2950386826000195"],"URL":"https:\/\/doi.org\/10.1016\/j.osep.2026.04.002","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2025.05.28.656557","asserted-by":"object"}]},"ISSN":["2950-3868"],"issn-type":[{"value":"2950-3868","type":"print"}],"subject":[],"published":{"date-parts":[[2026,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Basal Forebrain Volume is Associated With Cortical Amyloid Burden in Cognitively Unimpaired Older Adults at Varying Genetic Risk for Alzheimer\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"The American Journal of Geriatric Psychiatry: Open Science, Education, and Practice","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.osep.2026.04.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc. on behalf of American Association for Geriatric Psychiatry.","name":"copyright","label":"Copyright"}]}}