{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:55:35Z","timestamp":1792842935866,"version":"4.5.0"},"reference-count":61,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000055","name":"National Institute on Deafness and Other Communication Disorders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000055","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngologic Clinics of North America"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.otc.2020.03.001","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T20:53:38Z","timestamp":1587416018000},"page":"469-480","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Animal Models of Tinnitus"],"prefix":"10.1016","volume":"53","author":[{"given":"Alexander","family":"Galazyuk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas J.","family":"Brozoski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otc.2020.03.001_bib1","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1016\/j.amjmed.2010.02.015","article-title":"Prevalence and characteristics of tinnitus among US adults","volume":"123","author":"Shargorodsky","year":"2010","journal-title":"Am J Med"},{"key":"10.1016\/j.otc.2020.03.001_bib2","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1056\/NEJMcp1506631","article-title":"Tinnitus","volume":"378","author":"Bauer","year":"2018","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.otc.2020.03.001_bib3","first-page":"210","article-title":"Titus's tinnitus","volume":"14","author":"Dan","year":"2005","journal-title":"J\u00a0Hist Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib4","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1177\/0194599814547475","article-title":"Clinical practice guideline: tinnitus executive summary","volume":"151","author":"Tunkel","year":"2014","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.otc.2020.03.001_bib5","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1001\/jama.2016.11905","article-title":"Guidelines for tinnitus","volume":"316","author":"Tunkel","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.otc.2020.03.001_bib6","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1055\/s-0028-1082031","article-title":"Learning about tinnitus from an animal model","volume":"29","author":"Brozoski","year":"2008","journal-title":"Semin Hear"},{"key":"10.1016\/j.otc.2020.03.001_bib7","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1037\/0735-7044.102.6.811","article-title":"Phantom auditory sensation in rats: an animal model for tinnitus","volume":"102","author":"Jastreboff","year":"1988","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib8","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.heares.2010.12.003","article-title":"Tinnitus: models and mechanisms","volume":"276","author":"Kaltenbach","year":"2011","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib9","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.heares.2015.10.011","article-title":"Animal models of tinnitus","volume":"338","author":"Brozoski","year":"2016","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib10","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.heares.2012.09.010","article-title":"Tinnitus-related neural activity: theories of generation, propagation, and centralization","volume":"295","author":"Norena","year":"2013","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib11","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.heares.2013.12.004","article-title":"Tinnitus in men, mice (as well as other rodents), and machines","volume":"311","author":"Schaette","year":"2014","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib12","first-page":"99","article-title":"Homeostatic mechanisms and treatment of tinnitus","volume":"31","author":"Yang","year":"2013","journal-title":"Restor Neurol Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib13","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S0194-5998(99)70237-8","article-title":"Behavioral model of chronic tinnitus in rats","volume":"121","author":"Bauer","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"key":"10.1016\/j.otc.2020.03.001_bib14","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.heares.2004.03.005","article-title":"Evidence for tinnitus-related plasticity in the auditory and limbic system, demonstrated by arg3.1 and c-fos immunocytochemistry","volume":"195","author":"Mahlke","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib15","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0378-5955(03)00075-3","article-title":"A\u00a0behavioral paradigm to judge acute sodium salicylate-induced sound experience in rats: a new approach for an animal model on tinnitus","volume":"180","author":"Ruttiger","year":"2003","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib16","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.heares.2006.06.013","article-title":"Salicylate induced tinnitus: behavioral measures and neural activity in auditory cortex of awake rats","volume":"226","author":"Yang","year":"2007","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib17","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1097\/01.wnr.0000234754.11431.ee","article-title":"Reduction of inhibition in the inferior colliculus after inner hair cell loss","volume":"17","author":"Alkhatib","year":"2006","journal-title":"Neuroreport"},{"key":"10.1016\/j.otc.2020.03.001_bib18","doi-asserted-by":"crossref","first-page":"2564","DOI":"10.1002\/jnr.21699","article-title":"Tinnitus and inferior colliculus activity in chinchillas related to three distinct patterns of cochlear trauma","volume":"86","author":"Bauer","year":"2008","journal-title":"J\u00a0Neurosci Res"},{"key":"10.1016\/j.otc.2020.03.001_bib19","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1152\/jn.2002.88.2.699","article-title":"Cisplatin-induced hyperactivity in the dorsal cochlear nucleus and its relation to outer hair cell loss: relevance to tinnitus","volume":"88","author":"Kaltenbach","year":"2002","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.otc.2020.03.001_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S0378-5955(02)00575-0","article-title":"Effects of cochlear ablation on noise induced hyperactivity in the hamster dorsal cochlear nucleus: implications for the origin of noise induced tinnitus","volume":"172","author":"Zacharek","year":"2002","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib21","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1007\/s101620010030","article-title":"Assessing tinnitus and prospective tinnitus therapeutics using a psychophysical animal model","volume":"2","author":"Bauer","year":"2001","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.otc.2020.03.001_bib22","doi-asserted-by":"crossref","first-page":"2383","DOI":"10.1523\/JNEUROSCI.22-06-02383.2002","article-title":"Elevated fusiform cell activity in the dorsal cochlear nucleus of chinchillas with psychophysical evidence of tinnitus","volume":"22","author":"Brozoski","year":"2002","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib23","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.1523\/JNEUROSCI.4608-11.2012","article-title":"Noise overexposure alters long-term somatosensory-auditory processing in the dorsal cochlear nucleus--possible basis for tinnitus-related hyperactivity?","volume":"32","author":"Dehmel","year":"2012","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib24","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1288\/00005537-198803000-00008","article-title":"An animal model for tinnitus","volume":"98","author":"Jastreboff","year":"1988","journal-title":"Laryngoscope"},{"key":"10.1016\/j.otc.2020.03.001_bib25","series-title":"Textbook of audiological medicine","first-page":"571","article-title":"Management of the tinnitus patient","author":"Tyler","year":"2000"},{"key":"10.1016\/j.otc.2020.03.001_bib26","doi-asserted-by":"crossref","first-page":"e44519","DOI":"10.1371\/journal.pone.0044519","article-title":"Predisposition for and prevention of subjective tinnitus development","volume":"7","author":"Ahlf","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.otc.2020.03.001_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.heares.2012.03.009","article-title":"The cerebellum as a novel tinnitus generator","volume":"295","author":"Bauer","year":"2013","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib28","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0378-5955(02)00343-X","article-title":"Tinnitus in hamsters following exposure to intense sound","volume":"170","author":"Heffner","year":"2002","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib29","series-title":"The behavior of organisms; an experimental analysis","author":"Skinner","year":"1938"},{"key":"10.1016\/j.otc.2020.03.001_bib30","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.tins.2004.08.010","article-title":"The neuroscience of tinnitus","volume":"27","author":"Eggermont","year":"2004","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib31","doi-asserted-by":"crossref","first-page":"14972","DOI":"10.1523\/JNEUROSCI.4028-10.2010","article-title":"Ringing ears: the neuroscience of tinnitus","volume":"30","author":"Roberts","year":"2010","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.heares.2007.02.003","article-title":"Central neural activity in rats with tinnitus evaluated with manganese-enhanced magnetic resonance imaging (MEMRI)","volume":"228","author":"Brozoski","year":"2007","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib33","doi-asserted-by":"crossref","first-page":"e77674","DOI":"10.1371\/journal.pone.0077674","article-title":"Local NMDA receptor blockade attenuates chronic tinnitus and associated brain activity in an animal model","volume":"8","author":"Brozoski","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.otc.2020.03.001_bib34","first-page":"216","article-title":"Origin and function of short-latency inputs to the neural substrates underlying the acoustic startle reflex","volume":"8","author":"Gomez-Nieto","year":"2014","journal-title":"Front Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib35","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1037\/0735-7044.120.1.188","article-title":"Gap detection deficits in rats with tinnitus: a potential novel screening tool","volume":"120","author":"Turner","year":"2006","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0301-0082(98)00098-7","article-title":"The neurobiology of startle","volume":"59","author":"Koch","year":"1999","journal-title":"Prog Neurobiol"},{"key":"10.1016\/j.otc.2020.03.001_bib37","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/S0378-5955(04)00019-X","article-title":"A\u00a0novel behavioral paradigm for assessing tinnitus using schedule-induced polydipsia avoidance conditioning (SIP-AC)","volume":"190","author":"Lobarinas","year":"2004","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib38","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fneur.2015.00088","article-title":"Gap-prepulse inhibition of the acoustic startle reflex (GPIAS) for tinnitus assessment: current status and future directions","volume":"6","author":"Galazyuk","year":"2015","journal-title":"Front Neurol"},{"key":"10.1016\/j.otc.2020.03.001_bib39","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/nrneurol.2016.12","article-title":"Maladaptive plasticity in tinnitus--triggers, mechanisms and treatment","volume":"12","author":"Shore","year":"2016","journal-title":"Nat Rev Neurol"},{"key":"10.1016\/j.otc.2020.03.001_bib40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.brainres.2012.02.067","article-title":"Methodological optimization of tinnitus assessment using prepulse inhibition of the acoustic startle reflex","volume":"1485","author":"Longenecker","year":"2012","journal-title":"Brain Res"},{"key":"10.1016\/j.otc.2020.03.001_bib41","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnbeh.2016.00207","article-title":"Variable effects of acoustic trauma on behavioral and neural correlates of tinnitus in individual animals","volume":"10","author":"Longenecker","year":"2016","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib42","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.jneumeth.2015.07.001","article-title":"An improved approach to separating startle data from noise","volume":"253","author":"Grimsley","year":"2015","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.otc.2020.03.001_bib43","doi-asserted-by":"crossref","first-page":"140","DOI":"10.3389\/fnbeh.2019.00140","article-title":"Open(G)PIAS: r tinnitus screening and threshold estimation in rodents","volume":"13","author":"Gerum","year":"2019","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib44","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s13534-019-00109-9","article-title":"Proposal of conditional random interstimulus interval method for unconstrained enclosure based GPIAS measurement systems","volume":"9","author":"Choe","year":"2019","journal-title":"Biomed Eng Lett"},{"key":"10.1016\/j.otc.2020.03.001_bib45","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/j.jneumeth.2012.12.023","article-title":"A\u00a0novel behavioural approach to detecting tinnitus in the guinea pig","volume":"213","author":"Berger","year":"2013","journal-title":"J\u00a0Neurosci Methods"},{"key":"10.1016\/j.otc.2020.03.001_bib46","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1523\/JNEUROSCI.3960-15.2016","article-title":"Increased synchrony and bursting of dorsal cochlear nucleus fusiform cells correlate with tinnitus","volume":"36","author":"Wu","year":"2016","journal-title":"J\u00a0Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib47","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1152\/jn.00184.2013","article-title":"Is noise-induced cochlear neuropathy key to the generation of hyperacusis or tinnitus?","volume":"111","author":"Hickox","year":"2014","journal-title":"J\u00a0Neurophysiol"},{"key":"10.1016\/j.otc.2020.03.001_bib48","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.heares.2012.05.011","article-title":"Gap detection deficits in humans with tinnitus as assessed with the acoustic startle paradigm: does tinnitus fill in the gap?","volume":"295","author":"Fournier","year":"2013","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib49","first-page":"221","article-title":"Temporal processing evaluation in tinnitus patients: results on analysis of gap in noise and duration pattern test","volume":"25","author":"Gilani","year":"2013","journal-title":"Iran J Otorhinolaryngol"},{"key":"10.1016\/j.otc.2020.03.001_bib50","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.heares.2018.04.005","article-title":"Towards an objective test of chronic tinnitus: Properties of auditory cortical potentials evoked by silent gaps in tinnitus-like sounds","volume":"366","author":"Paul","year":"2018","journal-title":"Hear Res"},{"key":"10.1016\/j.otc.2020.03.001_bib51","series-title":"Tinnitus handbook","first-page":"1","article-title":"Epidemiology of tinnitus","author":"Davis","year":"2000"},{"key":"10.1016\/j.otc.2020.03.001_bib52","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3389\/fneur.2014.00179","article-title":"Behavioral models of tinnitus and hyperacusis in animals","volume":"5","author":"Hayes","year":"2014","journal-title":"Front Neurol"},{"key":"10.1016\/j.otc.2020.03.001_bib53","doi-asserted-by":"crossref","first-page":"741452","DOI":"10.1155\/2014\/741452","article-title":"Animal models of subjective tinnitus","volume":"2014","author":"von der Behrens","year":"2014","journal-title":"Neural Plast"},{"key":"10.1016\/j.otc.2020.03.001_bib54","doi-asserted-by":"crossref","first-page":"28","DOI":"10.3389\/fnsys.2012.00028","article-title":"Salicylate toxicity model of tinnitus","volume":"6","author":"Stolzberg","year":"2012","journal-title":"Front Syst Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib55","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1016\/j.neuropharm.2011.09.027","article-title":"A\u00a0dose-response analysis of the effects of L-baclofen on chronic tinnitus caused by acoustic trauma in rats","volume":"62","author":"Zheng","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.otc.2020.03.001_bib56","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s10162-016-0597-1","article-title":"Improving the reliability of tinnitus screening in laboratory animals","volume":"18","author":"Jones","year":"2017","journal-title":"J\u00a0Assoc Res Otolaryngol"},{"key":"10.1016\/j.otc.2020.03.001_bib57","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1037\/0735-7044.119.3.734","article-title":"Tinnitus and hearing loss in hamsters (Mesocricetus auratus) exposed to loud sound","volume":"119","author":"Heffner","year":"2005","journal-title":"Behav Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib58","doi-asserted-by":"crossref","first-page":"577","DOI":"10.3758\/s13428-011-0061-4","article-title":"A\u00a0two-choice sound localization procedure for detecting lateralized tinnitus in animals","volume":"43","author":"Heffner","year":"2011","journal-title":"Behav Res Methods"},{"key":"10.1016\/j.otc.2020.03.001_bib59","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1038\/jcbfm.2014.24","article-title":"Water deprivation induces neurovascular and cognitive dysfunction through vasopressin-induced oxidative stress","volume":"34","author":"Faraco","year":"2014","journal-title":"J\u00a0Cereb Blood flow Metab"},{"key":"10.1016\/j.otc.2020.03.001_bib60","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1146\/annurev.neuro.23.1.155","article-title":"Emotion circuits in the brain","volume":"23","author":"LeDoux","year":"2000","journal-title":"Annu Rev Neurosci"},{"key":"10.1016\/j.otc.2020.03.001_bib61","doi-asserted-by":"crossref","first-page":"3944","DOI":"10.1523\/JNEUROSCI.23-09-03944.2003","article-title":"Salicylate induces tinnitus through activation of cochlear NMDA receptors","volume":"23","author":"Guitton","year":"2003","journal-title":"J\u00a0Neurosci"}],"container-title":["Otolaryngologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666520300372?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666520300372?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T14:52:37Z","timestamp":1758466357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0030666520300372"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":61,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["S0030666520300372"],"URL":"https:\/\/doi.org\/10.1016\/j.otc.2020.03.001","relation":{},"ISSN":["0030-6665"],"issn-type":[{"value":"0030-6665","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Animal Models of Tinnitus","name":"articletitle","label":"Article Title"},{"value":"Otolaryngologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otc.2020.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}