{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:00:34Z","timestamp":1789502434464,"version":"build-2803163510"},"reference-count":89,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,4,1]],"date-time":"2023-04-01T00:00:00Z","timestamp":1680307200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngologic Clinics of North America"],"published-print":{"date-parts":[[2023,4]]},"DOI":"10.1016\/j.otc.2022.12.005","type":"journal-article","created":{"date-parts":[[2023,4,6]],"date-time":"2023-04-06T20:55:10Z","timestamp":1680814510000},"page":"389-402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Prognosis"],"prefix":"10.1016","volume":"56","author":[{"given":"Chihun","family":"Han","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nayel I.","family":"Khan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leila J.","family":"Mady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib1","doi-asserted-by":"crossref","first-page":"7300","DOI":"10.1245\/s10434-021-10318-1","article-title":"Stage migration and survival trends in laryngeal cancer","volume":"28","author":"Li","year":"2021","journal-title":"Ann Surg Oncol"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib2","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1002\/cncr.28608","article-title":"Treatment and survival in 10,429 patients with localized laryngeal cancer: a population-based analysis","volume":"120","author":"Misono","year":"2014","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib3","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1017\/S0022215119002433","article-title":"Outcomes of definitive radiotherapy for early laryngeal cancer in terms of survival and patterns of failure","volume":"133","author":"Adeel","year":"2019","journal-title":"Journal of Laryngology & Otology"},{"issue":"Suppl 1","key":"10.1016\/j.otc.2022.12.005_bib4","first-page":"E1247","article-title":"Trends in treatment and survival for advanced laryngeal cancer: a 20-year population-based study in The Netherlands","volume":"38","author":"Timmermans","year":"2016","journal-title":"Head Neck"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib6","doi-asserted-by":"crossref","first-page":"43","DOI":"10.4103\/apjon.apjon_35_18","article-title":"Frailty prevalence and characteristics in older adults with hematologic cancer: a descriptive study","volume":"6","author":"Atakul","year":"2019","journal-title":"Asia Pac J Oncol Nurs"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib7","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1093\/gerona\/59.3.M255","article-title":"Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care","volume":"59","author":"Fried","year":"2004","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"14","key":"10.1016\/j.otc.2022.12.005_bib8","doi-asserted-by":"crossref","first-page":"1930","DOI":"10.1200\/JCO.2006.10.5312","article-title":"Radiation therapy and the geriatric oncology patient","volume":"25","author":"Horiot","year":"2007","journal-title":"Journal of Clinical Oncology"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib9","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/annonc\/mdx486","article-title":"Alcohol and cigarette consumption predict mortality in patients with head and neck cancer: a pooled analysis within the International Head and Neck Cancer Epidemiology (INHANCE) Consortium","volume":"28","author":"Giraldi","year":"2017","journal-title":"Ann Oncol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib10","doi-asserted-by":"crossref","first-page":"18","DOI":"10.21147\/j.issn.1000-9604.2020.01.03","article-title":"Updates on larynx cancer epidemiology","volume":"32","author":"Nocini","year":"2020","journal-title":"Chin J Cancer Res"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib11","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1007\/s00405-014-3100-9","article-title":"Long-term trends in gender, T-stage, subsite and treatment for laryngeal cancer at a single center","volume":"271","author":"Brandstorp-Boesen","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"7","key":"10.1016\/j.otc.2022.12.005_bib12","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1001\/archotol.1991.01870190086018","article-title":"Gender influences subsite of origin of laryngeal carcinoma","volume":"117","author":"Stephenson","year":"1991","journal-title":"Archives of Otolaryngology\u2013Head & Neck Surgery"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib13","first-page":"573","article-title":"Impact of gender on survival in patients with laryngeal squamous cell carcinoma: a propensity score matching analysis","volume":"13","author":"Wang","year":"2020","journal-title":"Int J Clin Exp Pathol"},{"issue":"8","key":"10.1016\/j.otc.2022.12.005_bib14","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1158\/1055-9965.EPI-11-0246","article-title":"Sex disparities in cancer mortality and survival","volume":"20","author":"Cook","year":"2011","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib15","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1007\/s10654-018-0409-5","article-title":"Tumour stage and gender predict recurrence and second primary malignancies in head and neck cancer: a multicentre study within the INHANCE consortium","volume":"33","author":"Leoncini","year":"2018","journal-title":"European Journal of Epidemiology"},{"issue":"8","key":"10.1016\/j.otc.2022.12.005_bib16","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1002\/cam4.1136","article-title":"Hormone factors play a favorable role in female head and neck cancer risk","volume":"6","author":"Hashim","year":"2017","journal-title":"Cancer Med"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nrc.2016.30","article-title":"Sexual dimorphism in cancer","volume":"16","author":"Clocchiatti","year":"2016","journal-title":"Nature Reviews Cancer"},{"issue":"7","key":"10.1016\/j.otc.2022.12.005_bib18","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1001\/jamaoncol.2015.3113","article-title":"Performance Status in Patients With Cancer","volume":"1","author":"West","year":"2015","journal-title":"JAMA Oncology"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000521288","article-title":"Charlson comorbidity index: a critical review of clinimetric properties","volume":"91","author":"Charlson","year":"2022","journal-title":"Psychother Psychosom"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib21","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1002\/lary.22489","article-title":"Comorbid predictors of poor response to chemoradiotherapy for laryngeal squamous cell carcinoma","volume":"122","author":"Hu","year":"2012","journal-title":"The Laryngoscope"},{"issue":"10","key":"10.1016\/j.otc.2022.12.005_bib22","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.oraloncology.2010.07.008","article-title":"Comorbidity in head and neck cancer: a critical appraisal and recommendations for practice","volume":"46","author":"Paleri","year":"2010","journal-title":"Oral Oncology"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib23","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1097\/00005537-199711000-00009","article-title":"Validation of the Charlson comorbidity index in patients with head and neck cancer: a multi-institutional study","volume":"107","author":"Singh","year":"1997","journal-title":"The Laryngoscope"},{"key":"10.1016\/j.otc.2022.12.005_bib24","doi-asserted-by":"crossref","first-page":"17","DOI":"10.4137\/CMENT.S8610","article-title":"Cigarette smoking and alcohol ingestion as risk factors for laryngeal squamous cell carcinoma at kenyatta national hospital, kenya","volume":"5","author":"Menach","year":"2012","journal-title":"Clin Med Insights Ear Nose Throat"},{"issue":"2","key":"10.1016\/j.otc.2022.12.005_bib25","first-page":"219","article-title":"Alcohol's effects on the cardiovascular system","volume":"38","author":"Piano","year":"2017","journal-title":"Alcohol Res"},{"issue":"13","key":"10.1016\/j.otc.2022.12.005_bib26","doi-asserted-by":"crossref","first-page":"1914","DOI":"10.1002\/cncr.28695","article-title":"The 2014 surgeon general's report: \"The health consequences of smoking--50 years of progress\": a paradigm shift in cancer care","volume":"120","author":"Warren","year":"2014","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.otc.2022.12.005_bib27","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1002\/hed.25200","article-title":"Age-adjusted comorbidity and survival in locally advanced laryngeal cancer","volume":"40","author":"Group","year":"2018","journal-title":"Head & Neck"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib28","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1016\/j.joms.2013.04.028","article-title":"Nutritional considerations for head and neck cancer patients: a review of the literature","volume":"71","author":"Alshadwi","year":"2013","journal-title":"Journal of Oral and Maxillofacial Surgery"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib29","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.rpor.2015.03.001","article-title":"Malnutrition and cachexia in patients with head and neck cancer treated with (chemo)radiotherapy","volume":"20","author":"Gorenc","year":"2015","journal-title":"Rep Pract Oncol Radiother"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib30","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1002\/lary.24658","article-title":"Treatment complications and survival in advanced laryngeal cancer: a population-based analysis","volume":"124","author":"O'Neill","year":"2014","journal-title":"The Laryngoscope"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib31","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1007\/s12325-022-02074-9","article-title":"Managing cachexia in head and neck cancer: a systematic scoping review","volume":"39","author":"M\u00e4kitie","year":"2022","journal-title":"Advances in Therapy"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib32","doi-asserted-by":"crossref","DOI":"10.3390\/nu12113493","article-title":"Malnutrition prevalence according to the GLIM Criteria in head and neck cancer patients undergoing cancer treatment","volume":"12","author":"Steer","year":"2020","journal-title":"Nutrients"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib33","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1002\/(SICI)1097-0142(19990801)86:3<519::AID-CNCR22>3.0.CO;2-S","article-title":"The impact of nutritional status on the prognoses of patients with advanced head and neck cancer","volume":"86","author":"van Bokhorst-de van der Schueren","year":"1999","journal-title":"Cancer"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib34","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1080\/01635581.2021.1952446","article-title":"Impact of nutritional status on survival in head and neck cancer patients after total laryngectomy","volume":"74","author":"Santos","year":"2022","journal-title":"Nutrition and Cancer"},{"issue":"2","key":"10.1016\/j.otc.2022.12.005_bib35","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1177\/0003489414523564","article-title":"Effect of weight loss on short-term outcomes and costs of care after head and neck cancer surgery","volume":"123","author":"Gourin","year":"2014","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"10.1016\/j.otc.2022.12.005_bib36","first-page":"1","article-title":"The body mass index paradox in head and neck cancer: a systematic review and meta-analysis","author":"Hobday","year":"2022","journal-title":"Nutrition and Cancer"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib37","doi-asserted-by":"crossref","first-page":"3793","DOI":"10.1007\/s00405-014-3462-z","article-title":"The nutritional assessment of head and neck cancer patients","volume":"272","author":"Magnano","year":"2015","journal-title":"European Archives of Oto-Rhino-Laryngology"},{"issue":"6","key":"10.1016\/j.otc.2022.12.005_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/nu14061268","article-title":"Efficacy of the nutritional risk index, geriatric nutritional risk index, BMI, and GLIM-defined malnutrition in predicting survival of patients with head and neck cancer patients qualified for home enteral nutrition","volume":"14","author":"Przekop","year":"2022","journal-title":"Nutrients"},{"issue":"7","key":"10.1016\/j.otc.2022.12.005_bib39","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1002\/lary.25212","article-title":"Racial disparities in laryngeal cancer treatment and outcome: a population-based analysis of 24,069 patients","volume":"125","author":"Shin","year":"2015","journal-title":"The Laryngoscope"},{"issue":"7","key":"10.1016\/j.otc.2022.12.005_bib40","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1097\/01.mlg.0000224939.61503.83","article-title":"Racial disparities in patients with head and neck squamous cell carcinoma","volume":"116","author":"Gourin","year":"2006","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib41","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1177\/0194599819856305","article-title":"Influence of socioeconomic status on stage at presentation of laryngeal cancer in the United States","volume":"161","author":"Lebo","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"9","key":"10.1016\/j.otc.2022.12.005_bib42","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1002\/lary.24058","article-title":"Impact of race\/ethnicity on laryngeal cancer in patients treated at a Veterans Affairs Medical Center","volume":"123","author":"Sandulache","year":"2013","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib43","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1001\/jamaoto.2019.4310","article-title":"Association of medicaid expansion under the affordable care act with stage at diagnosis and time to treatment initiation for patients with head and neck squamous cell carcinoma","volume":"146","author":"Sineshaw","year":"2020","journal-title":"JAMA Otolaryngology Head & Neck Surgery"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib44","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1001\/jamaoto.2018.1792","article-title":"Association of the patient protection and affordable care act with insurance coverage for head and neck cancer in the SEER database","volume":"144","author":"Cannon","year":"2018","journal-title":"JAMA Otolaryngology\u2013Head & Neck Surgery"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib46","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.3390\/cancers7040888","article-title":"Tumor volumes and prognosis in laryngeal cancer","volume":"7","author":"Issa","year":"2015","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.otc.2022.12.005_bib47","series-title":"Laryngeal cancer","author":"Koroulakis","year":"2022"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib48","doi-asserted-by":"crossref","first-page":"2825","DOI":"10.1002\/lary.28532","article-title":"Distinct biomarker profiles and clinical characteristics in T1-T2 glottic and supraglottic carcinomas","volume":"130","author":"Wachters","year":"2020","journal-title":"Laryngoscope"},{"issue":"13","key":"10.1016\/j.otc.2022.12.005_bib49","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1016\/S0959-8049(02)00115-6","article-title":"Supraglottic and glottic carcinomas: clinically and biologically distinct entities?","volume":"38","author":"Hirvikoski","year":"2002","journal-title":"European Journal of Cancer"},{"issue":"10","key":"10.1016\/j.otc.2022.12.005_bib50","doi-asserted-by":"crossref","first-page":"e0164068","DOI":"10.1371\/journal.pone.0164068","article-title":"Risk of recurrence in laryngeal cancer","volume":"11","author":"Brandstorp-Boesen","year":"2016","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib51","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00405-013-2478-0","article-title":"Causes of death of patients with laryngeal cancer","volume":"271","author":"Ferlito","year":"2014","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib52","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1007\/s00405-007-0441-7","article-title":"Glottic versus supraglottic tumors: differential molecular profile","volume":"265","author":"Kourelis","year":"2008","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib53","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1016\/j.cell.2014.03.012","article-title":"Nuclear receptors, RXR, and the Big Bang","volume":"157","author":"Evans Ronald","year":"2014","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.otc.2022.12.005_bib54","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1002\/hed.25172","article-title":"Prognosis of subglottic carcinoma: is it really worse?","volume":"41","author":"Coskun","year":"2019","journal-title":"Head & Neck"},{"issue":"Suppl 2","key":"10.1016\/j.otc.2022.12.005_bib55","doi-asserted-by":"crossref","first-page":"S172","DOI":"10.1016\/S0385-8146(85)80054-7","article-title":"A histopathological study of carcinoma of the larynx","volume":"12","author":"Kurita","year":"1985","journal-title":"Auris Nasus Larynx"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1097\/01.MLG.0000160086.88523.C6","article-title":"Prognostic importance of paratracheal lymph node metastases","volume":"115","author":"Plaat","year":"2005","journal-title":"The Laryngoscope"},{"issue":"2","key":"10.1016\/j.otc.2022.12.005_bib57","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1177\/0194599815618190","article-title":"Subglottic squamous cell carcinoma: a population-based study of 889 cases","volume":"154","author":"Marchiano","year":"2015","journal-title":"Otolaryngology\u2013Head and Neck Surgery"},{"key":"10.1016\/j.otc.2022.12.005_bib58","series-title":"Neck cancer resection and dissection","author":"Gogna","year":"2022"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2273.1990.tb00436.x","article-title":"Prognosis in laryngeal carcinoma: tumour factors","volume":"15","author":"STELL","year":"1990","journal-title":"Clinical Otolaryngology & Allied Sciences"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib60","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1097\/01.mlg.0000161338.54515.b1","article-title":"The influence of lymph node metastasis in the treatment of squamous cell carcinoma of the oral cavity, oropharynx, larynx, and hypopharynx: N0 versus N+","volume":"115","author":"Layland","year":"2005","journal-title":"Laryngoscope"},{"issue":"11","key":"10.1016\/j.otc.2022.12.005_bib61","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1097\/01.mlg.0000240263.05198.a0","article-title":"Predictive value of lymph node metastases and extracapsular extension for the risk of distant metastases in laryngeal carcinoma","volume":"116","author":"Oosterkamp","year":"2006","journal-title":"Laryngoscope"},{"issue":"10","key":"10.1016\/j.otc.2022.12.005_bib62","doi-asserted-by":"crossref","first-page":"3131","DOI":"10.1002\/1097-0142(19931115)72:10<3131::AID-CNCR2820721039>3.0.CO;2-J","article-title":"Criteria for prognostic factors and for an enhanced prognostic system","volume":"72","author":"Burke","year":"1993","journal-title":"Cancer"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib63","doi-asserted-by":"crossref","first-page":"1140","DOI":"10.1002\/lary.26990","article-title":"Development and external validation of a risk-prediction model to predict 5-year overall survival in advanced larynx cancer","volume":"128","author":"Petersen","year":"2018","journal-title":"Laryngoscope"},{"issue":"18","key":"10.1016\/j.otc.2022.12.005_bib64","doi-asserted-by":"crossref","first-page":"2768","DOI":"10.1016\/j.ejca.2015.09.004","article-title":"Nomograms for predicting survival and recurrence in patients with adenoid cystic carcinoma. An international collaborative study","volume":"51","author":"Ganly","year":"2015","journal-title":"Eur J Cancer"},{"issue":"7","key":"10.1016\/j.otc.2022.12.005_bib65","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/j.ctrv.2006.07.002","article-title":"Current opinion in diagnosis and treatment of laryngeal carcinoma","volume":"32","author":"Marioni","year":"2006","journal-title":"Cancer Treat Rev"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.otc.2008.01.016","article-title":"Laryngeal cancer: diagnosis and preoperative work-up","volume":"41","author":"Chu","year":"2008","journal-title":"Otolaryngologic Clinics of North America"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib67","first-page":"885","article-title":"Histologic grading of malignancy and prognosis in glottic carcinoma of the larynx","volume":"4","author":"Jakobsson","year":"1975","journal-title":"Can J Otolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib68","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1186\/s13045-019-0779-5","article-title":"Immune checkpoint inhibitors of PD-L1 as cancer therapeutics","volume":"12","author":"Akinleye","year":"2019","journal-title":"Journal of Hematology & Oncology"},{"key":"10.1016\/j.otc.2022.12.005_bib69","doi-asserted-by":"crossref","first-page":"1856","DOI":"10.1056\/NEJMoa1602252","article-title":"Nivolumab for recurrent squamous-cell carcinoma of the head and neck","volume":"375","author":"Ferris","year":"2016","journal-title":"N Engl J Med"},{"issue":"14","key":"10.1016\/j.otc.2022.12.005_bib70","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1200\/JCO.2016.70.1524","article-title":"Pembrolizumab for platinum- and cetuximab-refractory head and neck cancer: results from a single-arm, phase II study","volume":"35","author":"Bauml","year":"2017","journal-title":"J Clin Oncol"},{"issue":"32","key":"10.1016\/j.otc.2022.12.005_bib71","doi-asserted-by":"crossref","first-page":"3838","DOI":"10.1200\/JCO.2016.68.1478","article-title":"Antitumor activity of pembrolizumab in biomarker-unselected patients with recurrent and\/or metastatic head and neck squamous cell carcinoma: results from the phase Ib KEYNOTE-012 expansion cohort","volume":"34","author":"Chow","year":"2016","journal-title":"J Clin Oncol"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib72","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1158\/1078-0432.CCR-15-1543","article-title":"Evaluation of PD-L1 expression and associated tumor-infiltrating lymphocytes in laryngeal squamous cell carcinoma","volume":"22","author":"Vassilakopoulou","year":"2016","journal-title":"Clinical Cancer Research"},{"key":"10.1016\/j.otc.2022.12.005_bib73","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.3389\/fimmu.2020.02105","article-title":"Tumor-infiltrating lymphocytes and their prognostic value in cutaneous melanoma","volume":"11","author":"Maibach","year":"2020","journal-title":"Front Immunol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib74","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.1038\/s41598-020-60255-4","article-title":"The prognostic implications of tumor infiltrating lymphocytes in colorectal cancer: a systematic review and meta-analysis","volume":"10","author":"Idos","year":"2020","journal-title":"Scientific Reports"},{"issue":"5","key":"10.1016\/j.otc.2022.12.005_bib75","doi-asserted-by":"crossref","first-page":"486","DOI":"10.3390\/biomedicines9050486","article-title":"Tumor-infiltrating lymphocytes in the tumor microenvironment of laryngeal squamous cell carcinoma: systematic review and meta-analysis","volume":"9","author":"Rodrigo","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.otc.2022.12.005_bib76","doi-asserted-by":"crossref","first-page":"759528","DOI":"10.3389\/fonc.2021.759528","article-title":"Overexpression of B7-H3 Is Associated With Poor Prognosis in Laryngeal Cancer","volume":"11","author":"Li","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.otc.2022.12.005_bib77","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1146\/annurev-pathol-012513-104715","article-title":"MicroRNAs in cancer","volume":"9","author":"Di Leva","year":"2014","journal-title":"Annu Rev Pathol"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib78","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1186\/s12935-021-02021-8","article-title":"Systematic review and meta-analysis of prognostic microRNA biomarkers for survival outcome in laryngeal squamous cell cancer","volume":"21","author":"Huang","year":"2021","journal-title":"Cancer Cell Int"},{"issue":"293","key":"10.1016\/j.otc.2022.12.005_bib79","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aaa8507","article-title":"Detection of somatic mutations and HPV in the saliva and plasma of patients with head and neck squamous cell carcinomas","volume":"7","author":"Wang","year":"2015","journal-title":"Science Translational Medicine"},{"key":"10.1016\/j.otc.2022.12.005_bib80","unstructured":"Kogo R, Manako T, Iwaya T, et al. Individualized circulating tumor DNA monitoring in head and neck squamous cell carcinoma. Cancer Medicine.n\/a(n\/a)."},{"issue":"2","key":"10.1016\/j.otc.2022.12.005_bib81","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1158\/1055-9965.EPI-09-0981","article-title":"A Systematic Review of p53 as a Prognostic Factor of Survival in Squamous Cell Carcinoma of the Four Main Anatomical Subsites of the Head and Neck","volume":"19","author":"Tandon","year":"2010","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"issue":"42","key":"10.1016\/j.otc.2022.12.005_bib82","doi-asserted-by":"crossref","first-page":"72621","DOI":"10.18632\/oncotarget.20004","article-title":"Circulating tumor DNA detection in head and neck cancer: evaluation of two different detection approaches","volume":"8","author":"Perdomo","year":"2017","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib83","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1093\/infdis\/jis698","article-title":"Human papillomavirus infection and laryngeal cancer risk: a systematic review and meta-analysis","volume":"207","author":"Li","year":"2013","journal-title":"J Infect Dis"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib84","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1001\/jamaoto.2020.3382","article-title":"Survival outcomes in human papillomavirus-associated nonoropharyngeal squamous cell carcinomas: a systematic review and meta-analysis","volume":"146","author":"Sahovaler","year":"2020","journal-title":"JAMA Otolaryngol Head Neck Surg"},{"issue":"9","key":"10.1016\/j.otc.2022.12.005_bib85","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1002\/cncr.30353","article-title":"The prognostic role of sex, race, and human papillomavirus in oropharyngeal and nonoropharyngeal head and neck squamous cell cancer","volume":"123","author":"Fakhry","year":"2017","journal-title":"Cancer"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib86","doi-asserted-by":"crossref","first-page":"e115931","DOI":"10.1371\/journal.pone.0115931","article-title":"Human papillomavirus prevalence in invasive laryngeal cancer in the United States","volume":"9","author":"Hernandez","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.otc.2022.12.005_bib87","first-page":"931","article-title":"High expression of c-Met and EGFR is associated with poor survival of patients with glottic laryngeal squamous cell carcinoma","volume":"15","author":"Jiang","year":"2018","journal-title":"Oncol Lett"},{"issue":"6","key":"10.1016\/j.otc.2022.12.005_bib88","doi-asserted-by":"crossref","first-page":"504","DOI":"10.14639\/0392-100X-2106","article-title":"The prognostic significance of E-cadherin expression in laryngeal squamous-cell carcinoma: a systematic review","volume":"38","author":"Re","year":"2018","journal-title":"Acta Otorhinolaryngol Ital"},{"issue":"4","key":"10.1016\/j.otc.2022.12.005_bib89","first-page":"944","article-title":"Clinical significance of Cyclin D1, FGF3 and p21 protein expression in laryngeal squamous cell carcinoma","volume":"19","author":"Jovanovic","year":"2014","journal-title":"J Buon"},{"key":"10.1016\/j.otc.2022.12.005_bib90","doi-asserted-by":"crossref","first-page":"854946","DOI":"10.3389\/fonc.2022.854946","article-title":"Prognostic and clinical significance of COX-2 overexpression in laryngeal cancer: a meta-analysis","volume":"12","author":"Du","year":"2022","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.otc.2022.12.005_bib91","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00405-012-2275-1","article-title":"High expression levels of COX-2 and P300 are associated with unfavorable survival in laryngeal squamous cell carcinoma","volume":"270","author":"Chen","year":"2013","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"12","key":"10.1016\/j.otc.2022.12.005_bib92","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.1038\/sj.bjc.6602647","article-title":"Bcl-2 expression predicts radiotherapy failure in laryngeal cancer","volume":"92","author":"Nix","year":"2005","journal-title":"Br J Cancer"}],"container-title":["Otolaryngologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666522001876?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666522001876?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T14:56:16Z","timestamp":1758466576000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0030666522001876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4]]},"references-count":89,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["S0030666522001876"],"URL":"https:\/\/doi.org\/10.1016\/j.otc.2022.12.005","relation":{},"ISSN":["0030-6665"],"issn-type":[{"value":"0030-6665","type":"print"}],"subject":[],"published":{"date-parts":[[2023,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognosis","name":"articletitle","label":"Article Title"},{"value":"Otolaryngologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otc.2022.12.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}