{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:37:02Z","timestamp":1786995422194,"version":"build-2736575974"},"reference-count":244,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","theclinics.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngologic Clinics of North America"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.otc.2024.07.022","type":"journal-article","created":{"date-parts":[[2024,9,30]],"date-time":"2024-09-30T07:45:00Z","timestamp":1727682300000},"page":"1-27","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["The Science of Cholesteatoma"],"prefix":"10.1016","volume":"58","author":[{"given":"Tirth R.","family":"Patel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher M.","family":"Welch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.otc.2024.07.022_bib1","doi-asserted-by":"crossref","first-page":"d1088","DOI":"10.1136\/bmj.d1088","article-title":"Cholesteatoma","volume":"342","author":"Bhutta","year":"2011","journal-title":"BMJ"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib2","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1001\/archotol.1986.03780100085014","article-title":"Hereditary congenital cholesteatoma. A variant of branchio-oto dysplasia","volume":"112","author":"Lipkin","year":"1986","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib3","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.1097\/01.mao.0000185042.46523.9b","article-title":"Surgical treatment of middle ear cholesteatoma in children with Down syndrome","volume":"26","author":"Bacciu","year":"2005","journal-title":"Otol Neurotol"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1007\/BF03349257","article-title":"Hearing loss in Turner syndrome: results of a multicentric study","volume":"31","author":"Bergamaschi","year":"2008","journal-title":"J\u00a0Endocrinol Invest"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib5","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1111\/coa.13544","article-title":"Cholesteatoma and family history: An international survey","volume":"45","author":"Collins","year":"2020","journal-title":"Clin Otolaryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib6","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1017\/S0022215108002673","article-title":"Familial cholesteatoma in East Anglia, UK","volume":"123","author":"Prinsley","year":"2009","journal-title":"J\u00a0Laryngol Otol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib7","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1017\/S0022215117000299","article-title":"Incidence, 10-year recidivism rate and prognostic factors for cholesteatoma","volume":"131","author":"Britze","year":"2017","journal-title":"J\u00a0Laryngol Otol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib8","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1097\/MAO.0b013e318181337f","article-title":"The investigation of the recurrence rate of cholesteatoma using Kaplan-Meier survival analysis","volume":"29","author":"Mishiro","year":"2008","journal-title":"Otol Neurotol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib9","doi-asserted-by":"crossref","first-page":"e18","DOI":"10.1055\/s-0039-1697989","article-title":"Recurrence of Cholesteatoma - A Retrospective Study Including 1,006 Patients for More than 33 Years","volume":"24","author":"M\u00f8ller","year":"2020","journal-title":"Int Arch Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.ijporl.2005.10.006","article-title":"Pediatric cholesteatoma: a retrospective review","volume":"70","author":"Schraff","year":"2006","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib11","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1002\/lary.24890","article-title":"Etiopathogenesis of acquired cholesteatoma: prominent theories and recent advances in biomolecular research","volume":"125","author":"Kuo","year":"2015","journal-title":"Laryngoscope"},{"key":"10.1016\/j.otc.2024.07.022_bib12","doi-asserted-by":"crossref","first-page":"854024","DOI":"10.1155\/2015\/854024","article-title":"Updates and knowledge gaps in cholesteatoma research","volume":"2015","author":"Kuo","year":"2015","journal-title":"BioMed Res Int"},{"issue":"Suppl 4","key":"10.1016\/j.otc.2024.07.022_bib13","first-page":"S1","article-title":"A\u00a0new theory on the pathogenesis of acquired cholesteatoma: Mucosal traction","volume":"125","author":"Jackler","year":"2015","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib14","first-page":"786","article-title":"Pathogenesis of attic cholesteatoma: clinical and immunohistochemical support for combination of retraction theory and proliferation theory","volume":"21","author":"Sudhoff","year":"2000","journal-title":"Am J Otol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1097\/MAO.0b013e31823c919c","article-title":"The pathogenesis of acquired cholesteatoma of the human middle ear: support for the migration hypothesis","volume":"33","author":"Karmody","year":"2012","journal-title":"Otol Neurotol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib16","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1288\/00005537-198503000-00005","article-title":"Basal lamina breaks in the histogenesis of cholesteatoma","volume":"95","author":"Chole","year":"1985","journal-title":"Laryngoscope"},{"key":"10.1016\/j.otc.2024.07.022_bib17","first-page":"394241","article-title":"Animal models of middle ear cholesteatoma","volume":"2011","author":"Yamamoto-Fukuda","year":"2011","journal-title":"J\u00a0Biomed Biotechnol"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib18","doi-asserted-by":"crossref","first-page":"e52718","DOI":"10.1371\/journal.pone.0052718","article-title":"Identification of novel cholesteatoma-related gene expression signatures using full-genome microarrays","volume":"7","author":"Klenke","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib19","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12964-020-00690-y","article-title":"Chronic inflammation of middle ear cholesteatoma promotes its recurrence via a paracrine mechanism","volume":"19","author":"Sch\u00fcrmann","year":"2021","journal-title":"Cell Commun Signal CCS"},{"issue":"8","key":"10.1016\/j.otc.2024.07.022_bib20","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1002\/lary.25834","article-title":"Acquired cholesteatoma epithelial hyperproliferation: Roles of cell proliferation signal pathways","volume":"126","author":"Xie","year":"2016","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib21","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s10162-019-00727-1","article-title":"Osteoclasts Modulate Bone Erosion in Cholesteatoma via RANKL Signaling","volume":"20","author":"Imai","year":"2019","journal-title":"J\u00a0Assoc Res Otolaryngol JARO"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib22","doi-asserted-by":"crossref","first-page":"4417","DOI":"10.1038\/s41467-023-40094-3","article-title":"Single-cell transcriptomics of human cholesteatoma identifies an activin A-producing osteoclastogenic fibroblast subset inducing bone destruction","volume":"14","author":"Shimizu","year":"2023","journal-title":"Nat Commun"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib23","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1001\/archotol.1988.01860240078028","article-title":"Treatment of sinus cholesteatoma. Long-term results and recurrence rate","volume":"114","author":"Lau","year":"1988","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib24","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/lary.20841","article-title":"Selective epitympanic dysventilation syndrome","volume":"120","author":"Marchioni","year":"2010","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib25","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.mehy.2011.03.041","article-title":"The contribution of selective dysventilation to attical middle ear pathology","volume":"77","author":"Marchioni","year":"2011","journal-title":"Med Hypotheses"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib26","doi-asserted-by":"crossref","first-page":"2845","DOI":"10.1002\/lary.24165","article-title":"Prevalence of ventilation blockages in patients affected by attic pathology: a case-control study","volume":"123","author":"Marchioni","year":"2013","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib27","first-page":"700","article-title":"Incudal folds and epitympanic aeration","volume":"17","author":"Palva","year":"1996","journal-title":"Am J Otol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib28","doi-asserted-by":"crossref","first-page":"E369","DOI":"10.1002\/lary.25937","article-title":"Epitympanum volume and tympanic isthmus area in temporal bones with retraction pockets","volume":"126","author":"Monsanto","year":"2016","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib29","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s00405-003-0623-x","article-title":"Etiopathogenesis of cholesteatoma","volume":"261","author":"Olszewska","year":"2004","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"1\u20132","key":"10.1016\/j.otc.2024.07.022_bib30","doi-asserted-by":"crossref","first-page":"71","DOI":"10.3109\/00016487809124722","article-title":"Fine morphology of the advancing front of cholesteatome--experimental and human","volume":"86","author":"Jackson","year":"1978","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib31","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1159\/000275513","article-title":"Cholesteatoma. Etiology, nosology and tympanoplasty","volume":"42","author":"Wullstein","year":"1980","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"issue":"8 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib32","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1288\/00005537-198908000-00002","article-title":"Post-traumatic cholesteatoma","volume":"99","author":"McKennan","year":"1989","journal-title":"Laryngoscope"},{"issue":"1\u20132","key":"10.1016\/j.otc.2024.07.022_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.3109\/00016488309132882","article-title":"The metaplastic and congenital origin of cholesteatoma","volume":"96","author":"Sad\u00e9","year":"1983","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib34","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.stem.2020.10.006","article-title":"A\u00a0Hierarchy of Proliferative and Migratory Keratinocytes Maintains the Tympanic Membrane","volume":"28","author":"Frumm","year":"2021","journal-title":"Cell Stem Cell"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib35","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1002\/lary.26940","article-title":"Evidence against the mucosal traction theory in cholesteatoma","volume":"128","author":"Pauna","year":"2018","journal-title":"Laryngoscope"},{"issue":"5\u20136","key":"10.1016\/j.otc.2024.07.022_bib36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.3109\/00016489009125164","article-title":"Persistent structural changes in the middle ear mucosa of the rat, after an experimentally induced episode of pneumococcal otitis media","volume":"109","author":"Hermansson","year":"1990","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib37","first-page":"7","article-title":"Cholesteatoma: a molecular and cellular puzzle","volume":"19","author":"Albino","year":"1998","journal-title":"Am J Otol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib38","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/MLG.0b013e31814faafa","article-title":"Transforming growth factor beta and wound healing in human cholesteatoma","volume":"118","author":"Huisman","year":"2008","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib39","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1288\/00005537-199206000-00004","article-title":"Ear canal cholesteatoma","volume":"102","author":"Holt","year":"1992","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib40","first-page":"CD007943","article-title":"Surgery for tympanic membrane retraction pockets","author":"Nankivell","year":"2010","journal-title":"Cochrane Database Syst Rev"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib41","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/0003489418823790","article-title":"Spontaneous Resolution of Cholesteatoma in a Patient on Long-Term Infliximab","volume":"128","author":"Chao","year":"2019","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib42","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1017\/S0022215113000601","article-title":"Acquired cholesteatoma: summary of the cascade of molecular events","volume":"127","author":"Louw","year":"2013","journal-title":"J\u00a0Laryngol Otol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib43","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1159\/000276789","article-title":"Identification of proliferating keratinocytes in middle ear cholesteatoma using the monoclonal antibody Ki-67","volume":"58","author":"Bujia","year":"1996","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"issue":"1\u20132","key":"10.1016\/j.otc.2024.07.022_bib44","first-page":"21","article-title":"Immunohistochemical detection of proliferating cell nuclear antigen in middle ear cholesteatoma","volume":"253","author":"Bujia","year":"1996","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib45","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1288\/00005537-199511000-00018","article-title":"Expressions of c-jun and p53 proteins in human middle ear cholesteatoma: relationship to keratinocyte proliferation, differentiation, and programmed cell death","volume":"105","author":"Shinoda","year":"1995","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib46","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1007\/BF00178279","article-title":"Immunohistochemical demonstration of c-myc oncogene product in middle ear cholesteatoma","volume":"252","author":"Holly","year":"1995","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"key":"10.1016\/j.otc.2024.07.022_bib47","doi-asserted-by":"crossref","first-page":"639896","DOI":"10.1155\/2014\/639896","article-title":"The c-MYC protooncogene expression in cholesteatoma","volume":"2014","author":"Palk\u00f3","year":"2014","journal-title":"BioMed Res Int"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib48","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1097\/01.mao.0000226290.04048.d9","article-title":"Evaluation of c-MYC status in primary acquired cholesteatoma by using fluorescence in\u00a0situ hybridization technique","volume":"27","author":"Ozturk","year":"2006","journal-title":"Otol Neurotol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib49","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.otohns.2008.07.019","article-title":"Chromosomal imbalances are associated with increased proliferation and might contribute to bone destruction in cholesteatoma","volume":"139","author":"Ecsedi","year":"2008","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib50","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1080\/00016480500312521","article-title":"Expression of the gap junction proteins connexin 26 and connexin 43 in human middle ear cholesteatoma","volume":"126","author":"Choung","year":"2006","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib51","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/lary.20649","article-title":"Pediatric cholesteatoma and variants in the gene encoding connexin 26","volume":"120","author":"James","year":"2010","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib52","first-page":"7","article-title":"Molecular biology of cholesteatoma","volume":"55","author":"Maniu","year":"2014","journal-title":"Romanian J Morphol Embryol Rev Roum Morphol Embryol"},{"key":"10.1016\/j.otc.2024.07.022_bib53","doi-asserted-by":"crossref","first-page":"1033965","DOI":"10.3389\/fgene.2022.1033965","article-title":"Novel candidate genes for cholesteatoma in chronic otitis media","volume":"13","author":"Lee","year":"2022","journal-title":"Front Genet"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib54","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1177\/000348949710600114","article-title":"Clinicopathological consultation. Ear cholesteatoma versus cholesterol granuloma","volume":"106","author":"Ferlito","year":"1997","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib55","first-page":"197","article-title":"Notes on the microbiology of cholesteatoma: clinical findings and treatment","volume":"29","author":"Ricciardiello","year":"2009","journal-title":"Acta Otorhinolaryngol Ital Organo Uff Della Soc Ital Otorinolaringol E Chir Cerv-facc"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib56","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1097\/MAO.0000000000002355","article-title":"Microbiome Analysis of Cholesteatoma by Gene Sequencing","volume":"40","author":"Weiss","year":"2019","journal-title":"Otol Neurotol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib57","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1002\/lary.22189","article-title":"aeruginosa infection increases morbidity in experimental cholesteatomas","volume":"121","author":"Jung","year":"2011","journal-title":"Laryngoscope"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib58","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1097\/MAO.0000000000000558","article-title":"Inactivation of specific Pseudomonas aeruginosa biofilm factors does not alter virulence in infected cholesteatomas","volume":"35","author":"Chole","year":"2014","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib59","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1097\/MAO.0000000000001088","article-title":"FleQ, a Transcriptional Activator, Is Required for Biofilm Formation In\u00a0Vitro But Does Not Alter Virulence in a Cholesteatomas Model","volume":"37","author":"Kao","year":"2016","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib60","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00405-006-0030-1","article-title":"Toll-like receptors 2, 3 and 4 (TLR-2, TLR-3 and TLR-4) are expressed in the microenvironment of human acquired cholesteatoma","volume":"263","author":"Szczepa\u0144ski","year":"2006","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib61","first-page":"1","article-title":"Expression of RANKL and proliferation abilities of cultured human middle ear cholesteatoma epithelial cells","volume":"62","author":"Miyasato","year":"2013","journal-title":"Hiroshima J Med Sci"},{"key":"10.1016\/j.otc.2024.07.022_bib62","doi-asserted-by":"crossref","first-page":"16683","DOI":"10.1038\/srep16683","article-title":"TLR4 drives the pathogenesis of acquired cholesteatoma by promoting local inflammation and bone destruction","volume":"5","author":"Si","year":"2015","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib63","doi-asserted-by":"crossref","first-page":"199","DOI":"10.3390\/cells9010199","article-title":"Stem Cell-Induced Inflammation in Cholesteatoma is Inhibited by the TLR4 Antagonist LPS-RS","volume":"9","author":"Sch\u00fcrmann","year":"2020","journal-title":"Cells"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib64","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0196-0709(91)90001-V","article-title":"Immunologically activated cells in aural cholesteatoma","volume":"12","author":"Schilling","year":"1991","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib65","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.yexmp.2009.12.006","article-title":"Immune cell profile in invasive cholesteatomas: preliminary findings","volume":"88","author":"Hussein","year":"2010","journal-title":"Exp Mol Pathol"},{"issue":"1\u20132","key":"10.1016\/j.otc.2024.07.022_bib66","doi-asserted-by":"crossref","first-page":"72","DOI":"10.3109\/00016488509108590","article-title":"Bone resorption in chronic otitis media. The role of mast cells","volume":"100","author":"Berger","year":"1985","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib67","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1111\/j.1524-475X.2008.00410.x","article-title":"Growth factors and cytokines in wound healing","volume":"16","author":"Barrientos","year":"2008","journal-title":"Wound Repair Regen"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib68","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1016\/S0092-8674(00)00178-1","article-title":"c-Jun and JunB antagonistically control cytokine-regulated mesenchymal-epidermal interaction in skin","volume":"103","author":"Szabowski","year":"2000","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib69","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00408-004-2534-z","article-title":"Different effects of growth factors on proliferation and matrix production of normal and fibrotic human lung fibroblasts","volume":"183","author":"Hetzel","year":"2005","journal-title":"Lung"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib70","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1046\/j.1523-1755.2001.059002579.x","article-title":"TGF-beta 1 induces proliferation in human renal fibroblasts via induction of basic fibroblast growth factor (FGF-2)","volume":"59","author":"Strutz","year":"2001","journal-title":"Kidney Int"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib71","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S1471-4906(01)01863-4","article-title":"Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation","volume":"22","author":"Buckley","year":"2001","journal-title":"Trends Immunol"},{"key":"10.1016\/j.otc.2024.07.022_bib72","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1146\/annurev.immunol.22.012703.104514","article-title":"Immunologically active autoantigens: the role of toll-like receptors in the development of chronic inflammatory disease","volume":"25","author":"Marshak-Rothstein","year":"2007","journal-title":"Annu Rev Immunol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib73","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib74","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00405-013-2402-7","article-title":"Expression of pattern recognition receptors in cholesteatoma","volume":"271","author":"Lee","year":"2014","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib75","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1007\/s00109-014-1217-3","article-title":"Molecular signaling of the HMGB1\/RAGE axis contributes to cholesteatoma pathogenesis","volume":"93","author":"Szczepanski","year":"2015","journal-title":"J\u00a0Mol Med Berl Ger"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib76","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.smim.2006.12.004","article-title":"TLR signaling","volume":"19","author":"Kawai","year":"2007","journal-title":"Semin Immunol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib77","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1016\/j.molmed.2007.09.002","article-title":"Signaling to NF-kappaB by Toll-like receptors","volume":"13","author":"Kawai","year":"2007","journal-title":"Trends Mol Med"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib78","doi-asserted-by":"crossref","first-page":"741","DOI":"10.3109\/00016489609137917","article-title":"Overexpression of tenascin in cholesteatoma and external auditory meatal skin compared to retroauricular epidermis","volume":"116","author":"Schilling","year":"1996","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib79","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/0196-0709(95)90148-5","article-title":"High levels of fibronectin in the stroma of aural cholesteatoma","volume":"16","author":"Schilling","year":"1995","journal-title":"Am J Otolaryngol"},{"key":"10.1016\/j.otc.2024.07.022_bib80","first-page":"50","article-title":"Identification of altered protein abundances in cholesteatoma matrix via mass spectrometry-based proteomic analysis","volume":"44","author":"Randall","year":"2015","journal-title":"J\u00a0Otolaryngol - Head Neck Surg J Oto-Rhino-Laryngol Chir Cervico-Faciale"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0194-59989670287-5","article-title":"Heat shock proteins in middle ear cholesteatoma","volume":"114","author":"Shinoda","year":"1996","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib82","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1097\/MAO.0b013e31819fe6ed","article-title":"Elevated level of tenascin and matrix metalloproteinase 9 correlates with the bone destruction capacity of cholesteatomas","volume":"30","author":"Juh\u00e1sz","year":"2009","journal-title":"Otol Neurotol"},{"key":"10.1016\/j.otc.2024.07.022_bib83","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12964-022-00953-w","article-title":"Review of potential medical treatments for middle ear cholesteatoma","volume":"20","author":"Sch\u00fcrmann","year":"2022","journal-title":"Cell Commun Signal CCS"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib84","doi-asserted-by":"crossref","first-page":"e39853","DOI":"10.1371\/journal.pone.0039853","article-title":"Sex differences in the response to viral infections: TLR8 and TLR9 ligand stimulation induce higher IL10 production in males","volume":"7","author":"Torcia","year":"2012","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib85","doi-asserted-by":"crossref","first-page":"e45171","DOI":"10.1371\/journal.pone.0045171","article-title":"Sex bias in susceptibility to MCMV infection: implication of TLR9","volume":"7","author":"Traub","year":"2012","journal-title":"PLoS One"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib86","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1016\/j.ijporl.2010.09.026","article-title":"TLR-9, NOD-1, NOD-2, RIG-I and immunoglobulins in recurrent otitis media with effusion","volume":"74","author":"Kim","year":"2010","journal-title":"Int J Pediatr Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib87","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00011-018-1132-0","article-title":"NOD-like receptor(s) and host immune responses with Pseudomonas aeruginosa infection","volume":"67","author":"Alhazmi","year":"2018","journal-title":"Inflamm Res"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib88","first-page":"514","article-title":"Nod1\/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells","volume":"179","author":"Park","year":"2007","journal-title":"J\u00a0Immunol Baltim Md. 1950"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib89","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1016\/j.anl.2018.12.011","article-title":"Expression of C-type lectin receptor mRNA in otitis media with effusion and chronic otitis media with and without cholesteatoma","volume":"46","author":"Doo","year":"2019","journal-title":"Auris Nasus Larynx"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib90","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1080\/00016489.2016.1269196","article-title":"Expression of C-type lectin receptor mRNA in chronic otitis media with cholesteatoma","volume":"137","author":"Kim","year":"2017","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib91","doi-asserted-by":"crossref","first-page":"475","DOI":"10.3109\/00016489.2013.878474","article-title":"Increased expression of Dec-205, Bcl-10, Tim-3, and Trem-1 mRNA in chronic otitis media with cholesteatoma","volume":"134","author":"Kim","year":"2014","journal-title":"Acta Otolaryngol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib92","doi-asserted-by":"crossref","first-page":"2991","DOI":"10.3390\/cells10112991","article-title":"Human \u03b2-Defensin 2 and Its Postulated Role in Modulation of the Immune Response","volume":"10","author":"Cie\u015blik","year":"2021","journal-title":"Cells"},{"issue":"6636","key":"10.1016\/j.otc.2024.07.022_bib93","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1038\/43088","article-title":"A\u00a0peptide antibiotic from human skin","volume":"387","author":"Harder","year":"1997","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib94","first-page":"306","article-title":"Morphopathogenesis of Adult Acquired Cholesteatoma","volume":"59","author":"Dambergs","year":"2023","journal-title":"Med Kaunas Lith"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib95","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1189\/jlb.0111004","article-title":"Human \u03b2-defensin-2 enhances IFN-\u03b3 and IL-10 production and suppresses IL-17 production in T\u00a0cells","volume":"89","author":"Kanda","year":"2011","journal-title":"J\u00a0Leukoc Biol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib96","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1097\/00005537-200307000-00018","article-title":"Expression of hypoxia inducible factor 1 alpha and Von Hippel Lindau protein in human middle ear cholesteatoma","volume":"113","author":"Adunka","year":"2003","journal-title":"Laryngoscope"},{"issue":"15","key":"10.1016\/j.otc.2024.07.022_bib97","doi-asserted-by":"crossref","first-page":"3403","DOI":"10.7150\/ijms.60617","article-title":"Cobalt chloride-stimulated hypoxia promotes the proliferation of cholesteatoma keratinocytes via the PI3K\/Akt signaling pathway","volume":"18","author":"Zhang","year":"2021","journal-title":"Int J Med Sci"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib98","doi-asserted-by":"crossref","first-page":"e198","DOI":"10.1097\/MAO.0000000000003395","article-title":"Nitric Oxide Is Locally Produced in the Human Middle Ear and Is Reduced by Acquired Cholesteatoma","volume":"43","author":"Westerberg","year":"2022","journal-title":"Otol Neurotol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib99","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1097\/00129492-200409000-00003","article-title":"A\u00a0possible role for nitric oxide in osteoclastogenesis associated with cholesteatoma","volume":"25","author":"Jung","year":"2004","journal-title":"Otol Neurotol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib100","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1007\/s00405-013-2614-x","article-title":"Quantitative measurement of m-RNA levels to assess expression of cyclooxygenase-II, inducible nitric oxide synthase and 12-lipoxygenase genes in middle ear cholesteatoma","volume":"271","author":"\u00c7atl\u0131","year":"2014","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"5\u20136","key":"10.1016\/j.otc.2024.07.022_bib101","doi-asserted-by":"crossref","first-page":"410","DOI":"10.3109\/00016489009122567","article-title":"Cholesteatoma debris as an activator of human monocytes. Potentiation of the production of tumor necrosis factor","volume":"110","author":"Iino","year":"1990","journal-title":"Acta Otolaryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib102","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s101620010041","article-title":"Keratin particle-induced osteolysis: a mouse model of inflammatory bone remodeling related to cholesteatoma","volume":"2","author":"Chole","year":"2001","journal-title":"J\u00a0Assoc Res Otolaryngol JARO"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib103","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1038\/s41577-022-00792-3","article-title":"Death by TNF: a road to inflammation","volume":"23","author":"van Loo","year":"2023","journal-title":"Nat Rev Immunol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib104","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/0196-0709(91)90041-D","article-title":"The role of tumor necrosis factor-alpha in bone resorption of cholesteatoma","volume":"12","author":"Yan","year":"1991","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib105","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/000348949110000212","article-title":"Tumor necrosis factor alpha in middle ear cholesteatoma and its effect on keratinocytes in\u00a0vitro","volume":"100","author":"Yan","year":"1991","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib106","first-page":"266","article-title":"Increased numbers of mast cells in human middle ear cholesteatomas: implications for treatment","volume":"19","author":"Albino","year":"1998","journal-title":"Am J Otol"},{"issue":"6053","key":"10.1016\/j.otc.2024.07.022_bib107","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/319516a0","article-title":"Stimulation of bone resorption and inhibition of bone formation in\u00a0vitro by human tumour necrosis factors","volume":"319","author":"Bertolini","year":"1986","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib108","doi-asserted-by":"crossref","first-page":"17","DOI":"10.21053\/ceo.2017.00304","article-title":"Expression of prostaglandin e2 receptors in acquired middle ear cholesteatoma","volume":"11","author":"Wang","year":"2018","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib109","doi-asserted-by":"crossref","first-page":"2163","DOI":"10.1084\/jem.162.6.2163","article-title":"Cachectin\/tumor necrosis factor stimulates collagenase and prostaglandin E2 production by human synovial cells and dermal fibroblasts","volume":"162","author":"Dayer","year":"1985","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib110","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1159\/000027756","article-title":"Acquired and congenital cholesteatoma: determination of tumor necrosis factor-alpha, intercellular adhesion molecule-1, interleukin-1-alpha and lymphocyte functional antigen-1 in the inflammatory process","volume":"62","author":"Akimoto","year":"2000","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"key":"10.1016\/j.otc.2024.07.022_bib111","first-page":"1","article-title":"Pathogenesis and surgical treatment of the middle ear cholesteatoma","volume":"361","author":"R\u00fcedi","year":"1979","journal-title":"Acta Oto-Laryngol Suppl"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib112","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1080\/00016489950181008","article-title":"Cytokines and adhesion molecules in middle ear cholesteatoma. A role in epithelial growth?","volume":"119","author":"Ottaviani","year":"1999","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib113","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/0196-0709(89)90034-3","article-title":"Colony-stimulating factor in middle ear cholesteatoma","volume":"10","author":"Huang","year":"1989","journal-title":"Am J Otolaryngol"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib114","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1007\/s00405-008-0707-8","article-title":"Complications of chronic otitis media with cholesteatoma during a 10-year period in Kosovo","volume":"265","author":"Mustafa","year":"2008","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib115","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3342\/ceo.2008.1.3.117","article-title":"The role of inflammatory mediators in the pathogenesis of otitis media and sequelae","volume":"1","author":"Juhn","year":"2008","journal-title":"Clin Exp Otorhinolaryngol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib116","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/00129492-200209000-00007","article-title":"Expression of epidermal growth factor, tumor necrosis factor-alpha, and interleukin-1alpha in chronic otitis media with or without cholesteatoma","volume":"23","author":"Yetiser","year":"2002","journal-title":"Otol Neurotol"},{"issue":"8774","key":"10.1016\/j.otc.2024.07.022_bib117","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0140-6736(91)91902-7","article-title":"Production of parathyroid-hormone-related protein by cholesteatoma cells in culture","volume":"338","author":"Cheshire","year":"1991","journal-title":"Lancet Lond Engl"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib118","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/00016489850183485","article-title":"Different production of interleukin-1alpha, interleukin-1beta and interleukin-8 from cholesteatomatous and normal epithelium","volume":"118","author":"Chung","year":"1998","journal-title":"Acta Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib119","doi-asserted-by":"crossref","first-page":"302","DOI":"10.3109\/00016489609137846","article-title":"Interleukin-1 alpha, interleukin-1 beta and interleukin-8 gene expression in human aural cholesteatomas","volume":"116","author":"Kim","year":"1996","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib120","first-page":"350","article-title":"Possible role of interleukin 1 alpha and interleukin 1 beta in the pathogenesis of cholesteatoma of the middle ear","volume":"13","author":"Schilling","year":"1992","journal-title":"Am J Otol"},{"issue":"8","key":"10.1016\/j.otc.2024.07.022_bib121","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1177\/000348949710600810","article-title":"Localization of transforming growth factor-beta-expressing cells and comparison with major extracellular components in aural cholesteatoma","volume":"106","author":"Lang","year":"1997","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib122","doi-asserted-by":"crossref","first-page":"e66725","DOI":"10.1371\/journal.pone.0066725","article-title":"Cholesteatoma fibroblasts promote epithelial cell proliferation through overexpression of epiregulin","volume":"8","author":"Yoshikawa","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib123","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0196-0709(93)90044-8","article-title":"Possible autocrine growth stimulation of cholesteatoma epithelium by transforming growth factor alpha","volume":"14","author":"Schulz","year":"1993","journal-title":"Am J Otolaryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib124","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1288\/00005537-199303000-00015","article-title":"Aberrant expression of epidermal growth factor receptor in aural cholesteatoma","volume":"103","author":"Buj\u00eda","year":"1993","journal-title":"Laryngoscope"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib125","first-page":"709","article-title":"Activation of the IL-6\/JAK\/STAT3 signaling pathway in human middle ear cholesteatoma epithelium","volume":"7","author":"Liu","year":"2014","journal-title":"Int J Clin Exp Pathol"},{"key":"10.1016\/j.otc.2024.07.022_bib126","doi-asserted-by":"crossref","first-page":"651207","DOI":"10.1155\/2013\/651207","article-title":"The role of EGFR\/PI3K\/Akt\/cyclinD1 signaling pathway in acquired middle ear cholesteatoma","volume":"2013","author":"Liu","year":"2013","journal-title":"Mediators Inflamm"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib127","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1080\/00016480802258802","article-title":"Expression of PTEN and phosphorylated Akt in human cholesteatoma epithelium","volume":"129","author":"Yune","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib128","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1080\/00016480600868430","article-title":"Survival signaling and terminal differentiation in cholesteatoma epithelium","volume":"127","author":"Huisman","year":"2007","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib129","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/S0194-5998(99)70334-7","article-title":"Signal transduction pathway in human middle ear cholesteatoma","volume":"120","author":"Myers","year":"1999","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib130","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1097\/MAO.0b013e3181dd15ef","article-title":"Expression of keratinocyte growth factor and its receptor in noncholesteatomatous and cholesteatomatous chronic otitis media","volume":"31","author":"Yamamoto-Fukuda","year":"2010","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib131","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.otpol.2012.11.002","article-title":"[Keratinocyte growth factor and its receptor in middle-ear cholesteatoma]","volume":"67","author":"Guzi\u0144ska-Ustymowicz","year":"2013","journal-title":"Otolaryngol Pol Pol Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib132","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s00418-012-0947-y","article-title":"Cholesteatoma-associated fibroblasts modulate epithelial growth and differentiation through KGF\/FGF7 secretion","volume":"138","author":"Raffa","year":"2012","journal-title":"Histochem Cell Biol"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib133","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1007\/s00405-014-3237-6","article-title":"In\u00a0vivo over-expression of KGF mimic human middle ear cholesteatoma","volume":"272","author":"Yamamoto-Fukuda","year":"2015","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib134","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.3109\/00016489.2014.907501","article-title":"KGFR as a possible therapeutic target in middle ear cholesteatoma","volume":"134","author":"Yamamoto-Fukuda","year":"2014","journal-title":"Acta Otolaryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib135","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1080\/00016480802251591","article-title":"Increased expression of p63 and survivin in cholesteatomas","volume":"129","author":"Park","year":"2009","journal-title":"Acta Otolaryngol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib136","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/MOO.0000000000000655","article-title":"Keratinocyte growth factor signaling promotes stem\/progenitor cell proliferation under p63 expression during middle ear cholesteatoma formation","volume":"28","author":"Yamamoto-Fukuda","year":"2020","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib137","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1007\/s001060050316","article-title":"[Basic fibroblast growth factor (b-FGF) in the perimatrix of cholesteatoma]","volume":"46","author":"Milewski","year":"1998","journal-title":"HNO"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib138","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1084\/jem.180.3.1141","article-title":"Overexpression of vascular permeability factor\/vascular endothelial growth factor and its receptors in psoriasis","volume":"180","author":"Detmar","year":"1994","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib139","first-page":"647","article-title":"Vascular endothelial growth factor production in normal epidermis and in benign and malignant epithelial skin tumors","volume":"75","author":"Weninger","year":"1996","journal-title":"Lab Investig J Tech Methods Pathol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib140","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1073\/pnas.82.1.119","article-title":"Type beta transforming growth factor: a bifunctional regulator of cellular growth","volume":"82","author":"Roberts","year":"1985","journal-title":"Proc Natl Acad Sci U\u00a0S\u00a0A"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib141","first-page":"121","article-title":"[Expression of transforming growth factor-beta 1 matrix metalloproteinase-1 and its inhibitor in human middle ear cholesteatoma]","volume":"37","author":"Yang","year":"2002","journal-title":"Zhonghua Er Bi Yan Hou Ke Za Zhi"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib142","first-page":"1154","article-title":"Wnt\/\u03b2-catenin signaling regulates pathogenesis of human middle ear cholesteatoma","volume":"12","author":"Lin","year":"2019","journal-title":"Int J Clin Exp Pathol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib143","doi-asserted-by":"crossref","first-page":"1158","DOI":"10.1080\/00016489.2017.1351040","article-title":"Evaluation of YAP signaling in a rat tympanic membrane under a continuous negative pressure load and in human middle ear cholesteatoma","volume":"137","author":"Akiyama","year":"2017","journal-title":"Acta Otolaryngol"},{"issue":"8","key":"10.1016\/j.otc.2024.07.022_bib144","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1016\/j.ajpath.2020.04.007","article-title":"L1CAM-ILK-YAP Mechanotransduction Drives Proliferative Activity of Epithelial Cells in Middle Ear Cholesteatoma","volume":"190","author":"Yamamoto-Fukuda","year":"2020","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib145","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1097\/MAO.0000000000001344","article-title":"The Role of Rho\/Rho-Kinase Pathway in the Pathogenesis of Cholesteatoma","volume":"38","author":"Ye\u015filova","year":"2017","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib146","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1172\/JCI42297","article-title":"Human keratinocytes are efficiently immortalized by a Rho kinase inhibitor","volume":"120","author":"Chapman","year":"2010","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib147","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1186\/scrt449","article-title":"The effect of Rho kinase inhibition on long-term keratinocyte proliferation is rapid and conditional","volume":"5","author":"Chapman","year":"2014","journal-title":"Stem Cell Res Ther"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib148","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1080\/15384101.2024.2345481","article-title":"Osteopontin-driven partial epithelial-mesenchymal transition governs the development of middle ear cholesteatoma","volume":"23","author":"Zeng","year":"2024","journal-title":"Cell Cycle Georget Tex"},{"key":"10.1016\/j.otc.2024.07.022_bib149","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.clinbiochem.2018.07.003","article-title":"The multiple functions and mechanisms of osteopontin","volume":"59","author":"Icer","year":"2018","journal-title":"Clin Biochem"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib150","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1002\/(SICI)1097-4652(200007)184:1<118::AID-JCP13>3.0.CO;2-Y","article-title":"Intracellular osteopontin is an integral component of the CD44-ERM complex involved in cell migration","volume":"184","author":"Zohar","year":"2000","journal-title":"J\u00a0Cell Physiol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib151","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.semcancer.2004.04.017","article-title":"Notch signaling in the integrated control of keratinocyte growth\/differentiation and tumor suppression","volume":"14","author":"Lefort","year":"2004","journal-title":"Semin Cancer Biol"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib152","doi-asserted-by":"crossref","first-page":"e1389","DOI":"10.1097\/MAO.0000000000003245","article-title":"Notch signaling in acquired middle ear cholesteatoma","volume":"42","author":"Fukuda","year":"2021","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib153","doi-asserted-by":"crossref","first-page":"815","DOI":"10.3109\/00016480903413657","article-title":"In\u00a0vitro cholesteatoma growth and secretion of cytokines","volume":"130","author":"Helgaland","year":"2010","journal-title":"Acta Otolaryngol"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib154","doi-asserted-by":"crossref","first-page":"2818","DOI":"10.1002\/lary.23547","article-title":"Cholesteatoma growth and proliferation: relevance with serpin B3","volume":"122","author":"Ho","year":"2012","journal-title":"Laryngoscope"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib155","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1097\/MAO.0b013e3181b4e91f","article-title":"Cholesteatoma growth and proliferation: posttranscriptional regulation by microRNA-21","volume":"30","author":"Friedland","year":"2009","journal-title":"Otol Neurotol"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib156","doi-asserted-by":"crossref","first-page":"e881","DOI":"10.1097\/MAO.0000000000002690","article-title":"Autophagy is deficient and may be negatively regulated by SERPINB3 in middle ear cholesteatoma","volume":"41","author":"Ho","year":"2020","journal-title":"Otol Neurotol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib157","first-page":"793","article-title":"Angiogenesis and angiogenic growth factors in middle ear cholesteatoma","volume":"21","author":"Sudhoff","year":"2000","journal-title":"Am J Otol"},{"issue":"4787","key":"10.1016\/j.otc.2024.07.022_bib158","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1126\/science.2432664","article-title":"Angiogenic factors","volume":"235","author":"Folkman","year":"1987","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib159","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1111\/j.1365-2133.1991.tb04942.x","article-title":"Epidermal cytokines and their roles in cutaneous wound healing","volume":"124","author":"McKay","year":"1991","journal-title":"Br J Dermatol"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib160","doi-asserted-by":"crossref","first-page":"1227","DOI":"10.1288\/00005537-199511000-00017","article-title":"Expression of a cell-cycle-associated nuclear antigen (MIB 1) in cholesteatoma and auditory meatal skin","volume":"105","author":"Sudhoff","year":"1995","journal-title":"Laryngoscope"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib161","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1046\/j.1365-2273.1997.00071.x","article-title":"Argyrophilic nucleolar organizer regions in auditory meatal skin and middle ear cholesteatoma","volume":"22","author":"Sudhoff","year":"1997","journal-title":"Clin Otolaryngol Allied Sci"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib162","first-page":"521","article-title":"Endothelial cell proliferation during angiogenesis. In\u00a0vitro modulation by basement membrane components","volume":"55","author":"Form","year":"1986","journal-title":"Lab Investig J Tech Methods Pathol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib163","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.amjoto.2005.07.009","article-title":"Cyclooxygenase 2 expression in otitis media with effusion","volume":"27","author":"Kakiuchi","year":"2006","journal-title":"Am J Otolaryngol"},{"issue":"3 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib164","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1288\/00005537-199403000-00018","article-title":"Acidic and basic FGF mRNA expression in the middle ear mucosa during experimental acute and chronic otitis media","volume":"104","author":"Koutnouyan","year":"1994","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib165","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3109\/00016489309135769","article-title":"Growth factors during proliferation of the middle ear mucosa","volume":"113","author":"Ryan","year":"1993","journal-title":"Acta Otolaryngol"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib166","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1177\/000348949610501008","article-title":"Basement membrane in middle ear cholesteatoma. Immunohistochemical and ultrastructural observations","volume":"105","author":"Sudhoff","year":"1996","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib167","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1177\/000348948609500307","article-title":"Secondary immune response in the middle ear: immunological, morphological, and physiological observations","volume":"95","author":"Ryan","year":"1986","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib168","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1001\/jamaoto.2013.1750","article-title":"Regulation of the angiogenesis of acquired middle ear cholesteatomas by inhibitor of DNA binding transcription factor","volume":"139","author":"Fukudome","year":"2013","journal-title":"JAMA Otolaryngol-- Head Neck Surg"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib169","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1001\/archotol.134.3.306","article-title":"Identification of Id1 in acquired middle ear cholesteatoma","volume":"134","author":"Zhang","year":"2008","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib170","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1111\/j.1365-2184.2010.00695.x","article-title":"The role of inhibitor of DNA-binding (Id1) in hyperproliferation of keratinocytes: the pathological basis for middle ear cholesteatoma from chronic otitis media","volume":"43","author":"Hamajima","year":"2010","journal-title":"Cell Prolif"},{"key":"10.1016\/j.otc.2024.07.022_bib171","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1177\/00034894941030S507","article-title":"Pathology of otitis media","volume":"163","author":"Wright","year":"1994","journal-title":"Ann Otol Rhinol Laryngol Suppl"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib172","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1007\/s00405-015-3621-x","article-title":"Comparative analysis of the expression of E-cadherin, \u03b2-catenin, and \u03b21 integrin in congenital and acquired cholesteatoma","volume":"273","author":"Lee","year":"2016","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib173","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/coa.12332","article-title":"Increased permeability of the epithelium of middle ear cholesteatoma","volume":"40","author":"Koizumi","year":"2015","journal-title":"Clin Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib174","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3109\/00016489409126040","article-title":"Integrin expression in middle ear cholesteatoma","volume":"114","author":"Dallari","year":"1994","journal-title":"Acta Otolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib175","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1172\/JCI115794","article-title":"Aberrant integrin expression during epidermal wound healing and in psoriatic epidermis","volume":"89","author":"Hertle","year":"1992","journal-title":"J\u00a0Clin Invest"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib176","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1111\/1523-1747.ep12366057","article-title":"Distinctive integrin expression in the newly forming epidermis during wound healing in humans","volume":"101","author":"Cavani","year":"1993","journal-title":"J\u00a0Invest Dermatol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib177","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1172\/JCI115782","article-title":"Expression, topography, and function of integrin receptors are severely altered in keratinocytes from involved and uninvolved psoriatic skin","volume":"89","author":"Pellegrini","year":"1992","journal-title":"J\u00a0Clin Invest"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib178","first-page":"217","article-title":"Functional characterization of middle ear mucosa residues in cholesteatoma samples","volume":"15","author":"Sudhoff","year":"1994","journal-title":"Am J Otol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib179","doi-asserted-by":"crossref","first-page":"e53739","DOI":"10.1371\/journal.pone.0053739","article-title":"Desmoglein 2 is less important than desmoglein 3 for keratinocyte cohesion","volume":"8","author":"Hartlieb","year":"2013","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib180","first-page":"621","article-title":"Stromal expression of matrix metalloprotease-9 in middle ear cholesteatomas","volume":"21","author":"Shibosawa","year":"2000","journal-title":"Am J Otol"},{"issue":"121","key":"10.1016\/j.otc.2024.07.022_bib181","first-page":"71","article-title":"Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect","volume":"34","author":"Dambergs","year":"2022","journal-title":"Iran J Otorhinolaryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib182","doi-asserted-by":"crossref","first-page":"451","DOI":"10.3109\/00016489609137872","article-title":"Expression of matrix-metalloproteinases and their inhibitors in human cholesteatomas","volume":"116","author":"Sch\u00f6nermark","year":"1996","journal-title":"Acta Otolaryngol"},{"issue":"5\u20136","key":"10.1016\/j.otc.2024.07.022_bib183","doi-asserted-by":"crossref","first-page":"437","DOI":"10.3109\/00016488409132918","article-title":"Pathogenic factors in bone resorption in cholesteatoma","volume":"97","author":"Abramson","year":"1984","journal-title":"Acta Otolaryngol"},{"issue":"1 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib184","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1177\/000348948309200122","article-title":"Organic acids and anaerobic microorganisms in the contents of the cholesteatoma sac","volume":"92","author":"Iino","year":"1983","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib185","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1002\/lary.23883","article-title":"Possible participation of acidic pH in bone resorption in middle ear cholesteatoma","volume":"124","author":"Nguyen","year":"2014","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib186","first-page":"39","article-title":"A\u00a0morphometric study of the effects of pressure on bone resorption in the middle ear of rats","volume":"11","author":"Huang","year":"1990","journal-title":"Am J Otol"},{"issue":"2 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib187","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1177\/000348948509400214","article-title":"Pressure-induced bone resorption in the middle ear","volume":"94","author":"Chole","year":"1985","journal-title":"Ann Otol Rhinol Laryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib188","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archotol.1987.01860040048015","article-title":"Pressures exerted by experimental cholesteatomas","volume":"113","author":"Orisek","year":"1987","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"1\u20132","key":"10.1016\/j.otc.2024.07.022_bib189","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1007\/s11010-014-2275-0","article-title":"Induction of cytokine production in cholesteatoma keratinocytes by extracellular high-mobility group box chromosomal protein 1 combined with DNA released by apoptotic cholesteatoma keratinocytes","volume":"400","author":"Chi","year":"2015","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib190","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000323831","article-title":"Expression of tumor necrosis factor-\u03b1, interleukin-1\u03b1, interleukin-6 and interleukin-10 in chronic otitis media with bone osteolysis","volume":"73","author":"Kuczkowski","year":"2011","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib191","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1001\/archotol.128.10.1129","article-title":"Evidence for microbial biofilms in cholesteatomas","volume":"128","author":"Chole","year":"2002","journal-title":"Arch Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib192","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00129492-200309000-00002","article-title":"Lipopolysaccharide concentration and bone resorption in cholesteatoma","volume":"24","author":"Peek","year":"2003","journal-title":"Otol Neurotol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib193","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s10162-008-0153-8","article-title":"Lipopolysaccharide-induced osteoclastogenesis from mononuclear precursors: a mechanism for osteolysis in chronic otitis","volume":"10","author":"Nason","year":"2009","journal-title":"J\u00a0Assoc Res Otolaryngol JARO"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib194","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1097\/00129492-200307000-00025","article-title":"Effects of nitric oxide on morphology of isolated cochlear outer hair cells: possible involvement in sensorineural hearing loss","volume":"24","author":"Jung","year":"2003","journal-title":"Otol Neurotol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib195","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1155\/MI.2005.210","article-title":"Suppressive activity of vitamin D3 on matrix metalloproteinase production from cholesteatoma keratinocytes in\u00a0vitro","volume":"2005","author":"Kobayashi","year":"2005","journal-title":"Mediators Inflamm"},{"issue":"5 Pt 1","key":"10.1016\/j.otc.2024.07.022_bib196","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/lary.5540870513","article-title":"Localization of collagenase in human middle ear cholesteatoma","volume":"87","author":"Abramson","year":"1977","journal-title":"Laryngoscope"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib197","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1055\/s-2007-1002611","article-title":"Plasminogen activators in epithelial biology","volume":"17","author":"Lazarus","year":"1991","journal-title":"Semin Thromb Hemost"},{"issue":"11","key":"10.1016\/j.otc.2024.07.022_bib198","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1016\/j.clinbiochem.2006.08.012","article-title":"Hexosaminidase as a new potential marker for middle ear cholesteatoma","volume":"39","author":"Olszewska","year":"2006","journal-title":"Clin Biochem"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib199","doi-asserted-by":"crossref","first-page":"365","DOI":"10.18388\/abp.2007_3258","article-title":"Role of N-acetyl-beta-d-hexosaminidase in cholesteatoma tissue","volume":"54","author":"Olszewska","year":"2007","journal-title":"Acta Biochim Pol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib200","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1097\/MAO.0b013e31824bae8d","article-title":"Cholesteatoma-associated pathogenicity: potential role of lysosomal exoglycosidases","volume":"33","author":"Olszewska","year":"2012","journal-title":"Otol Neurotol"},{"issue":"12","key":"10.1016\/j.otc.2024.07.022_bib201","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/modpathol.3880465","article-title":"Expression of matrix-degrading cysteine proteinase cathepsin K in cholesteatoma","volume":"14","author":"Hansen","year":"2001","journal-title":"Mod Pathol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib202","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1159\/000057787","article-title":"Bone resorption in chronic otitis media: the role of the osteoclast","volume":"64","author":"Jung","year":"2002","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"key":"10.1016\/j.otc.2024.07.022_bib203","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1111\/j.1749-6632.1997.tb51882.x","article-title":"The molecular biology of bone resorption due to chronic otitis media","volume":"830","author":"Chole","year":"1997","journal-title":"Ann N Y Acad Sci"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib204","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1002\/lary.5540940117","article-title":"Cellular and subcellular events of bone resorption in human and experimental cholesteatoma: the role of osteoclasts","volume":"94","author":"Chole","year":"1984","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib205","doi-asserted-by":"crossref","first-page":"6630","DOI":"10.1038\/s41598-017-07014-0","article-title":"Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation","volume":"7","author":"Alippe","year":"2017","journal-title":"Sci Rep"},{"issue":"16","key":"10.1016\/j.otc.2024.07.022_bib206","first-page":"4826","article-title":"The Relationship between the M1\/M2 Macrophage Polarization and the Degree of Ossicular Erosion in Human Acquired Cholesteatoma: An Immunohistochemical Study","volume":"11","author":"Bassiouni","year":"2022","journal-title":"J\u00a0Clin Med"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib207","first-page":"158","article-title":"Aural cholesteatoma: role of tumor necrosis factor-alpha in bone destruction","volume":"20","author":"Sastry","year":"1999","journal-title":"Am J Otol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib208","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1159\/000319897","article-title":"Expression of IL-17 and its role in bone destruction in human middle ear cholesteatoma","volume":"72","author":"Haruyama","year":"2010","journal-title":"ORL J Oto-Rhino-Laryngol Its Relat Spec"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib209","doi-asserted-by":"crossref","first-page":"1180","DOI":"10.1097\/01.mlg.0000224345.59291.da","article-title":"Expression of RANKL and OPG in middle ear cholesteatoma tissue","volume":"116","author":"Jeong","year":"2006","journal-title":"Laryngoscope"},{"issue":"8","key":"10.1016\/j.otc.2024.07.022_bib210","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1038\/nrg1122","article-title":"Genetic regulation of osteoclast development and function","volume":"4","author":"Teitelbaum","year":"2003","journal-title":"Nat Rev Genet"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib211","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1080\/00016480410017710","article-title":"Substance P upregulates osteoclastogenesis by activating nuclear factor kappa B in osteoclast precursors","volume":"125","author":"Sohn","year":"2005","journal-title":"Acta Otolaryngol"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib212","doi-asserted-by":"crossref","first-page":"3779","DOI":"10.1210\/en.2011-0255","article-title":"IL-1beta stimulates activin betaA mRNA expression in human skin fibroblasts through the MAPK pathways, the nuclear factor-kappaB pathway, and prostaglandin E2","volume":"152","author":"Arai","year":"2011","journal-title":"Endocrinology"},{"issue":"7","key":"10.1016\/j.otc.2024.07.022_bib213","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1111\/cas.14455","article-title":"TNF-\u03b1 enhances TGF-\u03b2-induced endothelial-to-mesenchymal transition via TGF-\u03b2 signal augmentation","volume":"111","author":"Yoshimatsu","year":"2020","journal-title":"Cancer Sci"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib214","doi-asserted-by":"crossref","first-page":"60","DOI":"10.3390\/ijms22010060","article-title":"Identifying the p65-Dependent Effect of Sulforaphene on Esophageal Squamous Cell Carcinoma Progression via Bioinformatics Analysis","volume":"22","author":"Han","year":"2020","journal-title":"Int J Mol Sci"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib215","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1152\/physrev.00002.2018","article-title":"Activin A in Mammalian Physiology","volume":"99","author":"Bloise","year":"2019","journal-title":"Physiol Rev"},{"issue":"8","key":"10.1016\/j.otc.2024.07.022_bib216","doi-asserted-by":"crossref","first-page":"6974","DOI":"10.1002\/jcb.26906","article-title":"Mechanisms involved in enhancement of osteoclast formation by activin-A","volume":"119","author":"Kajita","year":"2018","journal-title":"J\u00a0Cell Biochem"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib217","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1097\/00005537-200303000-00009","article-title":"Osteoclast stimulating and differentiating factors in human cholesteatoma","volume":"113","author":"Hamzei","year":"2003","journal-title":"Laryngoscope"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib218","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1080\/00016489.2020.1717609","article-title":"Expression of PTHrP and RANKL in acquired middle ear cholesteatoma epithelium","volume":"140","author":"Xie","year":"2020","journal-title":"Acta Otolaryngol (Stockh)"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib219","doi-asserted-by":"crossref","DOI":"10.1177\/00368504231199204","article-title":"Bone destruction in chronic otitis media is not mediated by the RANKL pathway or estrogen receptor-alpha","volume":"106","author":"Heo","year":"2023","journal-title":"Sci Prog"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib220","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1084\/jem.157.2.801","article-title":"Interleukin 1 stimulation of collagenase production by cultured fibroblasts","volume":"157","author":"Postlethwaite","year":"1983","journal-title":"J\u00a0Exp Med"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib221","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/0196-0709(95)90060-8","article-title":"Involvement of interleukin-1 in middle ear cholesteatoma","volume":"16","author":"Shiwa","year":"1995","journal-title":"Am J Otolaryngol"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib222","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/BF00628423","article-title":"Platelet-derived growth factor in middle ear cholesteatoma","volume":"251","author":"Fujioka","year":"1994","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib223","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1097\/00129492-200205000-00007","article-title":"Expression of bone morphogenetic protein-2 messenger ribonucleic acid in cholesteatoma fibroblasts","volume":"23","author":"Schmidt","year":"2002","journal-title":"Otol Neurotol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib224","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.amjoto.2013.06.007","article-title":"The effect of BMP-2, BMP-4 and BMP-6 on bone destruction of cholesteatoma presence","volume":"34","author":"Oger","year":"2013","journal-title":"Am J Otolaryngol"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib225","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib226","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1007\/s00405-017-4470-6","article-title":"MicroRNAs: effective elements in ear-related diseases and hearing loss","volume":"274","author":"Mahmoudian-Sani","year":"2017","journal-title":"Eur Arch Oto-Rhino-Laryngol"},{"issue":"15","key":"10.1016\/j.otc.2024.07.022_bib227","doi-asserted-by":"crossref","first-page":"12277","DOI":"10.3390\/ijms241512277","article-title":"Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review","volume":"24","author":"D\u017caman","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"2","key":"10.1016\/j.otc.2024.07.022_bib228","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.bbrc.2020.02.058","article-title":"Keratinocytes-derived exosomal miRNA regulates osteoclast differentiation in middle ear cholesteatoma","volume":"525","author":"Gong","year":"2020","journal-title":"Biochem Biophys Res Commun"},{"issue":"10","key":"10.1016\/j.otc.2024.07.022_bib229","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1002\/cbin.11002","article-title":"Down-regulation of exosomal miR-106b-5p derived from cholesteatoma perimatrix fibroblasts promotes angiogenesis in endothelial cells by overexpression of Angiopoietin 2","volume":"42","author":"Li","year":"2018","journal-title":"Cell Biol Int"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib230","first-page":"2110","article-title":"Post-transcriptional regulation by microrna-21 and let-7a microRNA in paediatric cholesteatoma","volume":"39","author":"Chen","year":"2011","journal-title":"J\u00a0Int Med Res"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib231","first-page":"1596","article-title":"Low expression of microRNA-125b enhances the expression of STAT3 and contributes to cholesteatoma growth","volume":"18","author":"Zang","year":"2022","journal-title":"Arch Med Sci AMS"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib232","doi-asserted-by":"crossref","first-page":"212","DOI":"10.5152\/iao.2023.22863","article-title":"Expression and Correlation Research of MicroRNA10a-5p and PIK3CA in Middle Ear Cholesteatoma","volume":"19","author":"Yang","year":"2023","journal-title":"J\u00a0Int Adv Otol"},{"issue":"9","key":"10.1016\/j.otc.2024.07.022_bib233","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1007\/s10529-014-1545-y","article-title":"Inflammation-induced miR-802 promotes cell proliferation in cholesteatoma","volume":"36","author":"Li","year":"2014","journal-title":"Biotechnol Lett"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib234","doi-asserted-by":"crossref","first-page":"447","DOI":"10.7150\/ijms.22410","article-title":"Downregulation of MiR-203a Disinhibits Bmi1 and Promotes Growth and Proliferation of Keratinocytes in Cholesteatoma","volume":"15","author":"Zang","year":"2018","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.otc.2024.07.022_bib235","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.molimm.2021.11.017","article-title":"MiR-142-5p directly targets cyclin-dependent kinase 5-mediated upregulation of the inflammatory process in acquired middle ear cholesteatoma","volume":"141","author":"Sui","year":"2022","journal-title":"Mol Immunol"},{"key":"10.1016\/j.otc.2024.07.022_bib236","article-title":"Next-generation sequencing of MicroRNA in acquired middle ear cholesteatoma","volume":"22","author":"Han","year":"2024","journal-title":"Laryngoscope"},{"issue":"1","key":"10.1016\/j.otc.2024.07.022_bib237","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/MAO.0000000000000590","article-title":"Immunotargeted photodynamic therapy for cholesteatoma: in\u00a0vitro results with anti-EGFR-coated indocyanine green nanocapsules","volume":"36","author":"Gluth","year":"2015","journal-title":"Otol Neurotol"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib238","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0196-0709(91)90142-3","article-title":"Effect of 5-fluorouracil in cholesteatoma development in an animal model","volume":"12","author":"Wright","year":"1991","journal-title":"Am J Otolaryngol"},{"issue":"6","key":"10.1016\/j.otc.2024.07.022_bib239","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1177\/014556139407300613","article-title":"Topical applications of 5-fluorouracil in the medical treatment of cholesteatoma of the middle ear","volume":"73","author":"Sala","year":"1994","journal-title":"Ear Nose Throat J"},{"issue":"4","key":"10.1016\/j.otc.2024.07.022_bib240","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.anl.2005.05.015","article-title":"Clinical efficacy of 5-fluorouracil (5-FU) topical cream for treatment of cholesteatoma","volume":"32","author":"Takahashi","year":"2005","journal-title":"Auris Nasus Larynx"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib241","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1177\/0194599818821863","article-title":"Evidence for oncolytic viral eradication of cholesteatoma in\u00a0vitro","volume":"160","author":"Samy","year":"2019","journal-title":"Otolaryngol Head Neck Surg"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib242","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1002\/lio2.307","article-title":"Engineered oncolytic virus for the treatment of cholesteatoma: A pilot in\u00a0vivo study","volume":"4","author":"Samy","year":"2019","journal-title":"Laryngoscope Investig Otolaryngol"},{"issue":"5","key":"10.1016\/j.otc.2024.07.022_bib243","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1097\/MOO.0000000000000651","article-title":"Oncolytic virotherapy: a potential therapeutic approach for cholesteatoma","volume":"28","author":"Lipschitz","year":"2020","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"issue":"3","key":"10.1016\/j.otc.2024.07.022_bib244","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.jphs.2022.08.002","article-title":"Generation of DNA-aptamers targeting galectin-7 for the identification of cholesteatoma residue","volume":"150","author":"Liu","year":"2022","journal-title":"J\u00a0Pharmacol Sci"}],"container-title":["Otolaryngologic Clinics of North America"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666524001191?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0030666524001191?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,26]],"date-time":"2025-08-26T13:13:58Z","timestamp":1756214038000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0030666524001191"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":244,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,2]]}},"alternative-id":["S0030666524001191"],"URL":"https:\/\/doi.org\/10.1016\/j.otc.2024.07.022","relation":{},"ISSN":["0030-6665"],"issn-type":[{"value":"0030-6665","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The Science of Cholesteatoma","name":"articletitle","label":"Article Title"},{"value":"Otolaryngologic Clinics of North America","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.otc.2024.07.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}