{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:17Z","timestamp":1761007517524,"version":"build-2065373602"},"reference-count":11,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4399,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To study the immunity of patients with sinus mycetoma by measuring serum immunoglobulins and IgG subclass levels.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Thirty patients with sinus mycetoma, 71 ordinary chronic rhinosinusitis patients without nasal polyps, and 77 ordinary chronic rhinosinusitis patients with nasal polyps were collected. In all subjects, the levels of total serum immunoglobulins and IgG subclasses were measured during surgical treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Among 30 patients with sinus mycetoma, decreased IgA level was found in 1 patient, and decreased IgM level was found in another 2 patients. There were no significant differences in the levels of total serum immunoglobulins or IgG subclasses between patients with sinus mycetoma and ordinary chronic rhinosinusitis patients with or without nasal polyps.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Immunologic defects cannot be detected in patients with sinus mycetoma by measuring levels of total serum immunoglobulins or IgG subclasses.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Immunoglobulin deficiency may not play an important role in the pathogenesis of sinus mycetoma. (Otolaryngol Head Neck Surg 2004;130:563\u20106.)<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2003.07.014","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T09:27:24Z","timestamp":1084440444000},"page":"563-566","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Serum Immunoglobulins and IgG Subclass Levels in Sinus Mycetoma"],"prefix":"10.1002","volume":"130","author":[{"suffix":"MD","given":"Rong\u2010San","family":"Jiang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital and Department of Medicine Chung\u2010Shan Medical University Taiwan Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"MD","given":"Chen\u2010Yi","family":"Hsu","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital and Department of Medicine Chung\u2010Shan Medical University Taiwan Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"379","article-title":"Immunologic aspects of chronic sinusitis.","volume":"20","author":"Lund VJ","year":"1991","journal-title":"J Otolaryngol"},{"key":"e_1_2_6_3_1","first-page":"507","article-title":"Serum immunoglobulins and IgG subclass levels in adults with chronic sinusitis: evidence for decreased IgG3 levels.","volume":"72","author":"Armenaka M","year":"1994","journal-title":"Ann Allergy"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(97)70223-9"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1081-1206(10)63411-4"},{"key":"e_1_2_6_6_1","first-page":"339","article-title":"Mycotic sinusitis.","volume":"51","author":"Eloy P","year":"1997","journal-title":"Acta Otorhinolaryngol Belg"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00463585"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989770001-9"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570244-X"},{"key":"e_1_2_6_10_1","first-page":"15","article-title":"IgG subclass levels in chronic rhinosinusitis.","volume":"32","author":"Scadding GK","year":"1994","journal-title":"Rhinology"},{"key":"e_1_2_6_11_1","first-page":"46","article-title":"Aspergillosis of the paranasal sinuses.","volume":"33","author":"Saeed SR","year":"1995","journal-title":"Rhinology"},{"key":"e_1_2_6_12_1","first-page":"606","article-title":"Chronic sinusitis, steroid\u2010dependent asthma, and IgG subclass and selective antibody deficiencies.","volume":"109","author":"Fadal RG","year":"1993","journal-title":"Otolaryngol Head Neck Surg"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2003.07.014","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2003.07.014","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2003.07.014","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:58:50Z","timestamp":1760968730000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2003.07.014"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":11,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1016\/j.otohns.2003.07.014"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2003.07.014","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}