{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T11:25:13Z","timestamp":1770895513827,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":4708,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,1]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To study the cellular characteristics of Relssner's membrane (RM) in temporal bones (TBs) from patients with endolymphatic hydrops with symptoms of Menlere's disease (EH\/+MD) and TBs with endolymphatic hydrops without symptoms of Meniere's disease (EH\/\u2010MD) in an effort to understand the role of endolymphatic hydrops in MD symptoms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>Comparative study of human TB histopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Materials<\/jats:title><jats:p>Epithelial and mesothelial cellularity of RM from control TBs, TBs from patients with EH\/+MD, and TBs from patients with EH\/\u2010MD were compared. The cellularity of epithelial and mesothelial cell nuclel (defined as number of cells\/ 100 \u03bcm width of RM) were counted along the width of RM. The width of RM was measured from the vestibular crest of the spiral ligament to the limbus spiralis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The cellular densities of epithelial cells in the basal and middle turns of RM were significantly higher in the EH\/+MD and EH\/\u2010MD groups compared with \u201ccontrols.\u201d There was no difference in epithelial cellularity between EH\/+MD and EH\/\u2010MD. There was a decrease in the number of mesothelial cells of RM in the basal turn in EH\/+MD and EH\/\u2010MD groups (statistically significant only in EH\/+MD group) when compared with controls. The number of mesothelial cells of RM in the middle turn in EH\/+MD and EH\/\u2010MD groups were significantly decreased compared with normals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Similar findings in cellularity of RM in temporal bones with EH\/+MD and EH\/\u2010MD suggest that pathophysiologic mechanisms other than hydrops may be responsible for symptoms in Meniere's disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2003.09.008","type":"journal-article","created":{"date-parts":[[2004,1,16]],"date-time":"2004-01-16T05:15:36Z","timestamp":1074230136000},"page":"113-119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Cellular Changes of Reissner's Membrane in Meniere's Disease: Human Temporal Bone Study"],"prefix":"10.1002","volume":"130","author":[{"given":"Sebahattin","family":"Cureoglu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology 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