{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T03:05:24Z","timestamp":1780715124591,"version":"3.54.1"},"reference-count":13,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4399,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,5]]},"abstract":"OBJECTIVE<\/jats:title>To develop a standardized porcine epistaxis model and evaluate the hemostatic effects of octyl\u2010cyanoacrylate (OCA).<\/jats:p><\/jats:sec>STUDY DESIGN AND SETTING<\/jats:title>Twenty\u2010four standardized full\u2010thickness wounds were created on the nasal septae of 7 pigs with a 4\u2010mm surgical punch. Wounds were randomized to no treatment or topical OCA before and after full heparinization. The rate of hemostasis, time to hemostasis, and number of applicators of OCA required to achieve complete hemostasis were determined and groups were compared with t<\/jats:italic> tests and X<\/jats:italic>2<\/jats:sup> tests.<\/jats:p><\/jats:sec>RESULTS<\/jats:title>Complete and sustained hemostasis was achieved in all wounds treated with OCA. The time to hemostasis was significantly shorter in the wounds treated with OCA vs those left to clot on their own (mean difference, 150\u00a0seconds; 95% CI, 92 to 209\u00a0seconds, P<0.001). None of the wounds required more than 3 applications of OCA.<\/jats:p><\/jats:sec>CONCLUSIONS<\/jats:title>We describe a simple and reproducible animal epistaxis model and demonstrate that OCA is effective in achieving hemostasis in this model.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2003.09.035","type":"journal-article","created":{"date-parts":[[2004,5,13]],"date-time":"2004-05-13T09:27:24Z","timestamp":1084440444000},"page":"553-557","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["A Porcine Epistaxis Model: Hemostatic Effects of Octylcyanoacrylate"],"prefix":"10.1002","volume":"130","author":[{"suffix":"MD","given":"Adam J.","family":"Singer","sequence":"first","affiliation":[{"name":"Departments of Emergency Medicine Department of Otolaryngology Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MD","given":"Steve A.","family":"McClain","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine Department of Otolaryngology Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"MD","given":"Arnold","family":"Katz","sequence":"additional","affiliation":[{"name":"Departments of Emergency Medicine Department of Otolaryngology Stony Brook New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0196-0709(92)90024-N"},{"key":"e_1_2_8_3_1","first-page":"129","article-title":"The frequency of epistaxis in a male population sample.","volume":"13","author":"Petruson B","year":"1975","journal-title":"Rhinology"},{"key":"e_1_2_8_4_1","volume-title":"Advance data from vital and health statistics; No. 320","author":"McCaig L","year":"2001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-7125(16)30390-X"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1067\/msy.2002.121377"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2002.01207.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1197\/aemj.9.5.449"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0264.1986.tb00528.x"},{"key":"e_1_2_8_10_1","volume-title":"Guide for the care and use of laboratory animals.","author":"National Research Council.","year":"1996"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/193293a0"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199901000-00003"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1988.tb08301.x"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487809121472"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2003.09.035","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2003.09.035","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2003.09.035","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:58:56Z","timestamp":1760968736000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2003.09.035"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,5]]},"references-count":13,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1016\/j.otohns.2003.09.035"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2003.09.035","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}