{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T02:13:58Z","timestamp":1789611238553,"version":"build-2803163510"},"reference-count":60,"publisher":"Wiley","issue":"S3","license":[{"start":{"date-parts":[[2016,11,21]],"date-time":"2016-11-21T00:00:00Z","timestamp":1479686400000},"content-version":"vor","delay-in-days":4648,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,3]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The objective of this study was to systematically review the literature on animal ototoxicity from ototopical medications. A secondary objective was to assess the relevance of animal data to the use of ototopical drops in clinical situations involving humans.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>We performed a MEDLINE search of the published literature using appropriate search terms to identify pertinent articles, which were reviewed, summarized, and tabulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>One hundred seventy\u2010three articles were reviewed; 61 articles were appropriate to the study question and were further analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Virtually all studies demonstrate that aminoglycoside antibiotics, when applied topically into the middle ear space, are ototoxic in experimental animals.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2003.12.008","type":"journal-article","created":{"date-parts":[[2004,3,30]],"date-time":"2004-03-30T05:20:36Z","timestamp":1080624036000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Animal Ototoxicity of Topical Antibiotics and the Relevance to Clinical Treatment of Human Subjects"],"prefix":"10.1002","volume":"130","author":[{"given":"Peter S.","family":"Roland","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The University of Texas Southwestern Medical Center Dallas Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonard","family":"Rybak","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Southern Illinois School of Medicine Springfield Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maureen","family":"Hannley","sequence":"additional","affiliation":[{"name":"American Academy of Otolaryngology\u2010Head and Neck Surgery Alexandria Virginia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Matz","sequence":"additional","affiliation":[{"name":"Loyola University Medical Center Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Stewart","sequence":"additional","affiliation":[{"name":"Bobby R. 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