{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T09:28:34Z","timestamp":1792056514942,"version":"4.4.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4429,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>An association between anterior glottic webs and velocardiofacial syndrome (chromosome 22q11.2 deletion) has previously been noted in a number of case reports. Our objective was to determine if the presence of such webs warrants a high index of suspicion for this chromosome deletion.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>This study was carried out in the Division of Pediatric Otolaryngology\u2010Head and Neck Surgery at Cincinnati Children's Hospital Medical Center. Chromosome 22q11.2 deletion status was determined for all patients endoscopically diagnosed with anterior glottic webs between July 1998 and December 2000. Families of patients who tested positive for the deletion were referred to the Cincinnati Children's Division of Human Genetics for additional evaluation and counseling.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Eleven of 17 patients (65%) with anterior glottic webs were positive for chromosome 22q11.2 deletion. Of these 11 patients, 5 showed subtle clinical manifestations of velocardiofacial syndrome and underwent genetic testing due only to the presence of a web. All 11 patients were diagnosed with velocardiofacial syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>We strongly recommend that all patients diagnosed with anterior glottic webs undergo fluorescence in situ hybridization evaluation for this chromosome deletion. (Otolaryngol Head Neck Surg 2004;130:415\u20107.)<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2003.12.014","type":"journal-article","created":{"date-parts":[[2004,4,26]],"date-time":"2004-04-26T05:21:14Z","timestamp":1082956874000},"page":"415-417","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":82,"title":["Association of Anterior Glottic Webs with Velocardiofacial Syndrome (Chromosome 22q11.2 Deletion)"],"prefix":"10.1002","volume":"130","author":[{"given":"R. Christopher","family":"Miyamoto","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\/Head and Neck Surgery Indiana University School of Medicine Indianapolis Indiana"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robin T.","family":"Cotton","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Cincinnati Children's Hospital Medical Center Department of Otolaryngology\/Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan F.","family":"Rope","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Cincinnati Children's Hospital Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hopkin","sequence":"additional","affiliation":[{"name":"Division of Human Genetics Cincinnati Children's Hospital Medical Center"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aliza P.","family":"Cohen","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Cincinnati Children's Hospital Medical Center Department of Otolaryngology\/Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sally R.","family":"Shott","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Cincinnati Children's Hospital Medical Center Department of Otolaryngology\/Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Rutter","sequence":"additional","affiliation":[{"name":"Division of Pediatric Otolaryngology\u2010Head and Neck Surgery Cincinnati Children's Hospital Medical Center Department of Otolaryngology\/Head and Neck Surgery University of Cincinnati College of Medicine Cincinnati Ohio"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1086\/515508"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(98)00067-6"},{"key":"e_1_2_6_4_1","first-page":"1409","article-title":"Otolaryngologic manifestations of the 22q11.2 deletion syndrome","volume":"128","author":"Djyce O","year":"2002","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"e_1_2_6_5_1","first-page":"56","article-title":"A new syndrome involving cleft palate cardiac anomalies, typical facies, and learning disabilities: Velo\u2010cardio\u2010facial syndrome","volume":"15","author":"Shprintzen RJ","year":"1978","journal-title":"Cleft Palate J"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992289703600502"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961111)65:4<309::AID-AJMG12>3.0.CO;2-Y"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00008480-200110000-00014"},{"key":"e_1_2_6_9_1","first-page":"924","article-title":"A genetic etiology for DiGeorge syndrome: Consistent deletions and microdeletions of 22q11","volume":"50","author":"Driscoll DA","year":"1992","journal-title":"Am J Hum Genet"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.30.10.822"},{"key":"e_1_2_6_11_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S0065-3101(23)00073-7","article-title":"The 22q11.2 deletion syndrome","volume":"48","author":"Emanual BS","year":"2001","journal-title":"Adv Pediatri"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00125817-200101000-00006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19961218)66:3<250::AID-AJMG2>3.0.CO;2-T"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970516)70:2<130::AID-AJMG5>3.0.CO;2-1"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980901)79:2<152::AID-AJMG12>3.0.CO;2-I"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19980217)75:5<537::AID-AJMG16>3.0.CO;2-L"},{"key":"e_1_2_6_17_1","first-page":"273","article-title":"Phenotypic variability of the cat eye syndrome. 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