{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T22:52:42Z","timestamp":1788648762291,"version":"build-2803163510"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4399,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>We sought to determine whether increasing temperature\u2010controlled radiofrequency tissue ablation (TCRFTA) treatments provide incremental improvement in outcomes of obstructive sleep apnea syndrome (OSAS).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Twenty\u2010six subjects randomized to TCRFTA treatment for mild to moderate OSAS were studied at baseline, 1\u00a0month after 3 tongue treatments (interim), and then 2\u00a0months after 2 additional tongue and palate treatments (final). Outcomes included OSA\u2010specific quality of life (Functional Outcomes of Sleep Questionnaire [FOSQ] and Symptoms of Nocturnal Obstruction and Related Events [SNORE25]), daytime sleepiness, and reaction times (slowest, median, and fastest).<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Interim outcomes were significantly better than baseline for FOSQ and SNORE25 (<jats:italic>P<\/jats:italic> &lt; 0.05), with a trend toward improvement for sleepiness (<jats:italic>P<\/jats:italic> = 0.06). Final outcomes were significantly better than interim outcomes for FOSQ, sleepiness, slowest and median reaction time (all <jats:italic>P<\/jats:italic> &lt; 0.05), and non\u2010significantly improved for SNORE25 (<jats:italic>P<\/jats:italic> = 0.30) and fastest reaction time (<jats:italic>P<\/jats:italic> = 0.18). All final outcomes were improved from baseline (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Three TCRFTA tongue treatments significantly improved OSA\u2010specific quality of life. An additional 2 TCRFTA tongue and palate treatment sessions further significantly improved quality of life and reaction times. 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