{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:40:29Z","timestamp":1761007229616,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4276,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine if <jats:italic>Pseudomonas aeruginosa<\/jats:italic> (PA) otitis media (OM) increases the risk of sensorineural hearing loss (SNHL) with semicircular canal transection in the guinea pig model.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>PA was injected transtympanically into both middle ears of pigmented guinea pigs. Saline\u2010injected animals served as controls. Two to 4\u00a0days after injection, one horizontal semicircular canal was transected and sealed. Hearing was tested using electrocochleography before and after transection.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>PA\u2010OM was induced in all PA\u2010injected ears. Five days after semicircular canal transection, click\u2010evoked thresholds were significantly elevated in ears with PA\u2010OM (<jats:italic>P<\/jats:italic> = 0.00009) but not in saline\u2010injected ears (<jats:italic>P<\/jats:italic> = 0.398).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Violation of the inner ear in the presence of PA\u2010OM is associated with increased risk of SNHL in the guinea pig.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Factors unique to PA infection may be responsible for SNHL with labyrinthine injury in humans with chronic otitis media.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2004.01.017","type":"journal-article","created":{"date-parts":[[2004,9,14]],"date-time":"2004-09-14T17:03:33Z","timestamp":1095181413000},"page":"248-252","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Hearing Loss with Semicircular Canal 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