{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T07:24:06Z","timestamp":1777620246016,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:p>The lymphoid follicles at the base of the tongue can be detected when examining the pharynx of adults, but the presence of large follicles, denoted \u201csevere\u201d hypertrophy of the base of the tongue (HBT) is rare. The objective of the present study was to identify severe HBT cases and their symptoms and to correlate them with the presence of pharyngolaryngeal signs and esophageal symptoms of gastroesophageal reflux (GER) in patients seen at a laryngology clinic. Severe HBT was considered to be present when the follicles prevented the view of the epiglottis or were massively distributed through the pharynx and larynx. Five cases of severe HBT were detected among 306 patients submitted to videolaryngoscopy over a period of 2 years, corresponding to 1.6% (5\/306) of the total sample studied. However, this index markedly increases to 4% (4\/101) among patients with pharyngolaryngeal signs of GER and reached 7.5% (4\/53) among patients presenting GER symptoms such as heartburn, regurgitation, retrosternal burning feeling, and dysphagia. The complaints due to severe HBT were noisy respiration, hoarseness, throat clearing, dry cough, globus pharyngeus, and nasal voice. We conclude that the frequency of hypertrophied follicles is increased in the presence of signs and symptoms of GER and those HBT symptoms are confused with those of GER, except for nasal voice and noisy respiration.<\/jats:p>","DOI":"10.1016\/j.otohns.2004.02.040","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T12:41:28Z","timestamp":1097584888000},"page":"378-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Severe Hypertrophy of the Base of the Tongue in Adults"],"prefix":"10.1002","volume":"131","author":[{"given":"Rui Celso Martins","family":"Mamede","sequence":"first","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaringology, and Surgery of Head and Neck University Hospital Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco Ver\u00edssimo","family":"De Mello\u2010Filho","sequence":"additional","affiliation":[{"name":"Departments of Ophthalmology, Otorhinolaringology, and Surgery of Head and Neck University Hospital Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto Oliveira","family":"Dantas","sequence":"additional","affiliation":[{"name":"Internal Medicine University Hospital Faculty of Medicine of Ribeir\u00e3o Preto University of S\u00e3o Paulo S\u00e3o Paulo Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Immunology of oral diseases","author":"Lehner T","year":"1992"},{"key":"e_1_2_6_3_1","volume-title":"Imunologia","author":"Roitt IM","year":"1997"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199609000-00022"},{"key":"e_1_2_6_5_1","first-page":"44","article-title":"Development and structure of the lymphoepithelial pharyngeal ring in Macacus rhesus","volume":"84","author":"Zharikova OL","year":"1983","journal-title":"Arch Anat Histol Embryol"},{"key":"e_1_2_6_6_1","first-page":"825","article-title":"Histological study of human lingual tonsil, especially changes with aging","volume":"95","author":"Kamata T","year":"1992","journal-title":"Nippon Jibiinkoka Gakkai Kaiho"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199306000-00012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000433-199212000-00014"},{"key":"e_1_2_6_9_1","first-page":"381","volume-title":"Otorrinolaringologia: princpios and prtica","author":"Cruz OML","year":"1994"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770080414016"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198402000-00005"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1959.tb44877.x"},{"key":"e_1_2_6_13_1","first-page":"922","article-title":"The lingual tonsil","volume":"103","author":"Golding\u2010Wood DG","year":"1989","journal-title":"A neglected symptomatic structure? J Laryngol"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)31075-6"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988108900506"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2000.98362"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197709000-00002"},{"issue":"9","key":"e_1_2_6_18_1","first-page":"491","article-title":"A critical evaluation of proton pump inhibitors in the treatment of gastroesophageal reflux disease","volume":"6","author":"Berardi RR","year":"2000","journal-title":"Am J Manag Care"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1258\/0022215001906020"},{"key":"e_1_2_6_20_1","first-page":"221","volume-title":"Cirurgia de Cabea e Pescoo","author":"Cachin Y","year":"1989"},{"key":"e_1_2_6_21_1","first-page":"3","article-title":"Classificao dos tumores da Boca e Orofaringe","volume":"19","author":"Mamede RCM","year":"1995","journal-title":"Rev Bras Cir Cabea Pescoo"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2004.02.040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2004.02.040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2004.02.040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:02:53Z","timestamp":1760965373000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2004.02.040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["10.1016\/j.otohns.2004.02.040"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2004.02.040","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,10]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}