{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T09:02:18Z","timestamp":1792659738101,"version":"4.5.0"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the efficacy of proton\u2010pump inhibitor (PPI) therapy for chronic laryngo\u2010pharyngitis treated with lifestyle modification.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Double\u2010blind, randomized trial comparing two\u2010month Rabeprazole (20\u00a0mg b.i.d.) to placebo control.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Compared to baseline, both PPI and control patients had significant improvement in total reflux symptoms (<jats:italic>P<\/jats:italic> = 0.002 and <jats:italic>P<\/jats:italic> = 0.03 respectively), with significant improvement in \u201claryngo\u2010pharyngeal\u201d but not \u201ctypical\u201d reflux symptoms. No significant difference was noted for change in reflux symptoms between PPI\u2010treated and control patients (<jats:italic>P<\/jats:italic> = 0.44). Significant global improvement was noted by 50% of control and 53% of PPI\u2010treated patients (<jats:italic>P<\/jats:italic> = 1.0). No significant differences were noted within or between treatment groups for change in health status or videostrobolaryngoscopy grade. Lifestyle modification compliance correlated significantly with global improvement.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Compared to baseline, lifestyle modification for 2\u00a0months significantly improved chronic laryngo\u2010pharyngitis symptoms. When compared to control, treatment with a PPI failed to demonstrate significantly greater improvement in reflux symptoms, health status, or laryngeal appearance.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2004.03.037","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T12:41:28Z","timestamp":1097584888000},"page":"342-350","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":158,"title":["Proton Pump Inhibitor Therapy for Chronic Laryngo\u2010Pharyngitis: A Randomized Placebo\u2010Control Trial"],"prefix":"10.1002","volume":"131","author":[{"given":"David L.","family":"Steward","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery Division of Gastroenterology Department of Medicine Center for Biostatistical Services University of Cincinnati College of Medicine Cincinnati OH"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith 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