{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,27]],"date-time":"2026-07-27T23:57:52Z","timestamp":1785196672901,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4246,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2004,10]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>In a previous study, we reported that the contralateral undissected neck was the most common site of failure in patients treated for squa\u2010mous cell carcinoma of the supraglottic larynx. Since then, we have altered our treatment of all patients with T2\u2010T4 supraglottic cancer and selective T1 cases to include routine bilateral neck dissection. In the present study, we compare the long\u2010term efficacy of routine bilateral neck dissections to historic controls in the treatment of patients with supraglottic cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A retrospective chart review on all patients undergoing primary surgery for supraglottic carcinoma between 1989 and 2000 was performed. All had undergone routine bilateral neck dissection. The most proximal area of recurrent disease was identified as the site of recurrence. Rates of recurrence, 2\u2010year overall survival, and 2\u2010year disease\u2010specific survival were calculated. Results were compared to historical data using Fisher's exact test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Of 180 patients identified, 115 patients with minimum 2\u2010year follow\u2010up and meeting exclusion criteria were included in the analysis. Four patients (3.5%) experienced local recurrence, 9 patients (7.8%) had cervical recurrence, and 8 patients had distant spread (7.0%). Recurrence in the neck (7.8%) has been significantly reduced from the historical recurrence rate (20%) prior to instituting routine bilateral neck dissections (<jats:italic>P<\/jats:italic> = 0.009). The 2\u2010year survival increased from 72% to 82.6% (<jats:italic>P<\/jats:italic> = 0.0408).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION AND SIGNIFICANCE<\/jats:title><jats:p>Routine bilateral neck dissection decreases cervical recurrence and appears to improve survival in the management of supraglottic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2004.04.024","type":"journal-article","created":{"date-parts":[[2004,10,12]],"date-time":"2004-10-12T12:41:28Z","timestamp":1097584888000},"page":"485-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Efficacy of Routine Bilateral Neck Dissection in the Management of Supraglottic Cancer"],"prefix":"10.1002","volume":"131","author":[{"given":"Robert J.","family":"Chiu","sequence":"first","affiliation":[{"name":"University of Pittsburgh School of Medicine and Eye and Ear Institute Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eugene N.","family":"Myers","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine and Eye and Ear Institute Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonas T.","family":"Johnson","sequence":"additional","affiliation":[{"name":"University of Pittsburgh School of Medicine and Eye and Ear Institute Pittsburgh PA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197405)33:5<1253::AID-CNCR2820330510>3.0.CO;2-L"},{"key":"e_1_2_5_3_1","first-page":"10","article-title":"Cancer of the larynx","volume":"11","author":"Harwood AR","year":"1982","journal-title":"J 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