{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:30:47Z","timestamp":1761006647490,"version":"build-2065373602"},"reference-count":41,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4154,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The aim of this study was to investigate the effects of topotecan (Hycamtin), a topoisomerase I inhibiting anticancer agent, on antioxidant enzymes (SOD, CAT, and GSH\u2010Px) and TBA\u2010RS values of the submandibular glands of the rabbits.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>The study was conveyed in two groups (Group I, II) and control with a total of 24 rabbits. Eight rabbits in group I received intravenous (i.v.) topotecan (0.25\u00a0mg\/kg once daily) for 3\u00a0days. Eight rabbits in group II received i.v. topotecan (0.5\u00a0mg\/kg once daily) for 3\u00a0days. On the 15th day after administration of topotecan, sub\u2010mandibular glands were removed and levels of the SOD, CAT, and GSH\u2010Px and the TBA\u2010RS in the sub\u2010mandibular glands of the rabbits were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>SOD, CAT, and GSH\u2010Px values were significantly higher in high\u2010dose topotecan group compared to control group (<jats:italic>P<\/jats:italic> &lt; 0.05). SOD and TBA\u2010RS values were significantly higher in high\u2010dose topotecan group compared to low\u2010dose topotecan group (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>It was concluded that, to prevent the hazardous effects of oxygen free radicals due to topotecan, antioxidant enzymes SOD, CAT, and GSH\u2010Px were increased. The higher levels of the TBA\u2010RS values in group II showed that permanent damage was present because of high\u2010dose topotecan administration in the submandibular glands of the rabbits.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2004.09.012","type":"journal-article","created":{"date-parts":[[2005,1,4]],"date-time":"2005-01-04T07:16:53Z","timestamp":1104823013000},"page":"136-140","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Efficacy of topotecan treatment on antioxidant enzymes and TBA\u2010RS levels in submandibular glands of rabbits: An experimental study"],"prefix":"10.1002","volume":"132","author":[{"given":"Nuray Bayar","family":"Muluk","sequence":"first","affiliation":[{"name":"ENT Department Kirikkale University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00dc\u00e7ler","family":"Kisa","sequence":"additional","affiliation":[{"name":"Biochemistry Department Kirikkale University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Ka\u00e7maz","sequence":"additional","affiliation":[{"name":"Biochemistry Department Kirikkale University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alpaslan","family":"Apan","sequence":"additional","affiliation":[{"name":"Anesthesiology and Reanimation Department Kirikkale University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"CAN","family":"Ko\u00e7","sequence":"additional","affiliation":[{"name":"ENT Department Kirikkale University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179947"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)64862-9"},{"issue":"1","key":"e_1_2_6_4_1","first-page":"61","article-title":"Free radicals of oxygen and superoxide dismutase. 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