{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:38:32Z","timestamp":1761007112499,"version":"build-2065373602"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4003,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To analyze oncologic results in patients with glottic cancers treated respectively, by laser CO<jats:sub>2<\/jats:sub> or open surgery, taking into account specific\u2010disease survival, rate of locoregional recurrences, and their salvageability.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Retrospective study of 198 patients treated from January 1993 to June 2002\u00a0in the department of otorhinolaryngology at a Catholic university in Rome.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Glottic carcinoma were treated by laser CO<jats:sub>2<\/jats:sub> cordectomy in 132 patients (group 1) and by open surgery in 66 patients (group 2). The statistical analysis was performed by Kaplan Meyer method, log rank test, and <jats:italic>x<\/jats:italic> <jats:sup>2<\/jats:sup>, test.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The log\u2010rank test points out significant differences between the 2\u00a0groups regarding specific\u2010disease survival; no differences were found for disease\u2010free survival. Within group 1, 16 patients developed local failure, which was retreated in 6 cases with laser surgery; in 9 (6.8%) with total laryngectomy, only 1 case was inoperable. In this group, 10 patients (62.5%) were salvaged. Within group 2, 18 patients developed local recurrences, which was retreated in 14 (21.21%) cases with total laryngectomy; the other 4 cases were not suitable for surgery. Of these 18, 8 patients (44.5%) were salvaged.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS AND SIGNIFICANCE<\/jats:title><jats:p>Our results show significant differences between the 2\u00a0groups concerning the specific\u2010disease survival and the salvageability of local recurrences. In fact, in group 1 we found a higher salvage rate and a lower incidence of total laryngectomy. As already suggested, laser therapy leaves the laryngeal cartilaginous framework intact, avoiding the spread of the tumor out of laryngeal organ and resulting in a more favorable oncologic outcome.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.01.038","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T11:47:16Z","timestamp":1118404036000},"page":"857-861","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Laser carbon dioxide cordectomy versus open surgery in the treatment of glottic carcinoma: Our results"],"prefix":"10.1002","volume":"132","author":[{"given":"Maurizio","family":"Maurizi","sequence":"first","affiliation":[{"name":"Institute of Otorhinolaringology, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Almadori","sequence":"additional","affiliation":[{"name":"Institute of Otorhinolaringology, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gaetano","family":"Plaudetti","sequence":"additional","affiliation":[{"name":"Institute of Otorhinolaringology, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De Corso","family":"Eugenio","sequence":"additional","affiliation":[{"name":"Institute of Otorhinolaringology, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacopo","family":"Galli","sequence":"additional","affiliation":[{"name":"Institute of Otorhinolaringology, Universit\u00e0 Cattolica del Sacro Cuore Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198107000-00014"},{"key":"e_1_2_6_3_1","first-page":"4070","article-title":"Laser surgery of laryngeal cancer (T1 glottis). 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