{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:51Z","timestamp":1790959971990,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":4003,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To evaluate the effectiveness of laser myringotomy in otitis media with effusion (OME) in patients with nasopharyngeal carcinoma (NPC).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Laser myringotomy was performed with a CO<jats:sub>2<\/jats:sub> laser otoscope in 53\u00a0NPC patients (68 ears) and 32\u00a0non\u2010NPC patients (37 ears). All patients had a history of OME.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>In the NPC group, 40% of ears developed persistent perforation, 37% had recurrent OME, and 23% were free of disease. In the non\u2010NPC group, only 3% of ears developed persistent perforation, and 43% were free of disease. Significant differences in perforation and disease\u2010free state were evident between the 2\u00a0groups. Tumor stage was found to be a significant determining factor for clinical outcome in NPC group.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Laser myringotomy for NPC group carries a significantly higher risk of persistent perforation and lower rate of cure. This procedure may be considered for early staging NPC patients with serious OME symptoms.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.01.042","type":"journal-article","created":{"date-parts":[[2005,6,10]],"date-time":"2005-06-10T11:47:16Z","timestamp":1118404036000},"page":"924-927","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Laser myringotomy for otitis media with effusion in nasopharyngeal carcinoma patients"],"prefix":"10.1002","volume":"132","author":[{"given":"Chung\u2010Feng","family":"Hwang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology National Sun Yat\u2010Sen University Kaohsiung Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Yen","family":"Chien","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology National Sun Yat\u2010Sen University Kaohsiung 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