{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:29:28Z","timestamp":1761006568728,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3973,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To identify the incidence of parapharyngeal space (PPS) recurrences and how they impact survival in advanced\u2010stage soft\u2010palate carcinoma patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING:<\/jats:title><jats:p>One hundred thirty\u2010seven patients' charts were reviewed from 1971 to 1996. Inclusion criteria were patients who received a per\u2010oral resection, discontinuous neck dissection, and postoperative adjuvant radiation therapy; 15 patients met criteria for inclusion. The incidence of PPS recurrences, regional failure, and survival were endpoints that were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>There were no local failures in our study. Regional failures excluding the PPS (levels I\u2010V) were 27%, and 40% occurred within the PPS. Cervical adenopathy was associated with 83% of the PPS recurrences. Median survival for PPS recurrences was 26\u00a0months, compared with 67\u00a0months for levels I\u2010V recurrences (n = ns).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS:<\/jats:title><jats:p>The incidence of PPS recurrences is substantial in advanced\u2010stage soft\u2010palate cancer. PPS recurrences negatively impact survival; without effective salvage techniques for these recurrences or effective adjuvant therapy, poor patient outcomes can be expected.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.03.007","type":"journal-article","created":{"date-parts":[[2005,7,18]],"date-time":"2005-07-18T09:51:22Z","timestamp":1121680282000},"page":"66-69","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Advanced Soft Palate Cancer: The Clinical Importance of the Parapharyngeal Space"],"prefix":"10.1002","volume":"133","author":[{"given":"Wade G.","family":"Douglas","sequence":"first","affiliation":[{"name":"Department of Head and Neck, Plastics and Reconstructive Surgery"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nestor R.","family":"Rigual","sequence":"additional","affiliation":[{"name":"Department of Head and Neck, Plastics and Reconstructive 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