{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T08:14:50Z","timestamp":1791015290206,"version":"4.1.0"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3638,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec><jats:title>BACKGROUND AND OBJECTIVE<\/jats:title><jats:p>Although systemic steroids in sudden sensorineural hearing loss (SSHL) appears to be the most effective and the most widely accepted treatment today, a significant number of patients do not respond to steroid treatment or they cannot receive steroids for medical reasons. Intratympanic (IT) administration of steroids appears to be an alternative or additional method of management without the side effects of intravenous steroids. The aim of this study is to investigate the effectiveness and safeness of IT administration of steroids in patients who had not responded to IV treatment and to compare treatment efficacy with controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Our study consisted of 37 patients with SSHL who, at the end of 10\u00a0days of therapy with intravenous steroids as a 1st line treatment, had pure\u2010tone 4\u2010frequency (0.5, 1, 2, and 4\u00a0kHz) average (PTA) of worse than 30\u00a0dB or worse than 10\u00a0dB from the contralateral ear (defined as failed intravenous treatment). They were randomized into 2\u00a0groups, treatment and control. The 19 patients of the treatment group received approximately 0.5\u00a0mL sterile aqueous suspension of methylprednisolone acetate in a concentration of 80\u00a0mg\/2\u00a0mL by direct injection. The procedure was carried out 4 times within a 15\u2010day period. An audiogram was performed before each injection and approximately 1.5\u00a0months after the last session.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>All patients tolerated the procedure well. No perforation or infection was noticed in any of the patients at their last visit. With regard to the 19 patients who received intratympanic treatment, in 9 patients, the PTA threshold improved more than 10 db, in 10 patients there was no change greater than 10 db, and no patients deteriorated more than 10 db. In the control group, none of the patients showed any change greater than 10 db. The difference was statistically significant (<jats:italic>P<\/jats:italic> = 0.002). The treatment group showed an improvement in mean PTA of 14.9\u00a0dB, whereas the control group showed a deterioration of 0.8\u00a0dB, and this difference also was statistically significant (<jats:italic>P<\/jats:italic> = 0.0005). IT treatment (<jats:italic>P<\/jats:italic> = 0.0001), better post\u2010IV PTA (<jats:italic>P<\/jats:italic> = 0.0008), and absence of vertigo (<jats:italic>P<\/jats:italic> = 0.02) were good predictors of the outcome. In contrast, sex, age, affected ear, days to admission, and pattern of the initial audiogram showed no significant influence on the outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION AND SIGNIFICANCE<\/jats:title><jats:p>IT steroid administration after failed intravenous steroids is a safe and effective treatment in sudden sensorineural hearing loss.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.03.081","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T07:27:42Z","timestamp":1148628462000},"page":"940-945","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":124,"title":["Intratympanic Steroid Treatment in Idiopathic Sudden Sensorineural Hearing Loss: A Control Study"],"prefix":"10.1002","volume":"134","author":[{"given":"John","family":"Xenellis","sequence":"first","affiliation":[{"name":"Department of Otolaryngology School of Medicine University of Athens 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