{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T04:11:12Z","timestamp":1784693472786,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3942,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objective:<\/jats:title>\n                    <jats:p>To investigate the efficacy of dexamethasone inner ear perfusion by intratympanic injection in hearing loss, tinnitus, aural fullness, and vertigo in the treatment of unilateral M\u00e9ni\u00e8re's disease and compare it with the control group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design and Setting:<\/jats:title>\n                    <jats:p>A prospective, randomized, double\u2010blind study with 2\u2010year follow\u2010up comparing changes secondary to dexamethasone inner ear perfusion versus placebo consisting of saline solution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Patients:<\/jats:title>\n                    <jats:p>Twenty\u2010two patients having definite M\u00e9ni\u00e8re's disease as outlined by the 1995 American Academy of Otolaryngology\u2010Head and Neck Surgery Committee on Hearing and Equilibrium. All the patients were older than 18 years of age and were not receiving any other form of treatment with steroids for their M\u00e9ni\u00e8re's disease.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method:<\/jats:title>\n                    <jats:p>Five consecutive daily intratympanic injections of dexamethasone or placebo to the involved ear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results:<\/jats:title>\n                    <jats:p>In the dexamethasone group at 2\u2010year follow\u2010up, complete control of vertigo (class A) was achieved in 9 of 11 patients (82%) and substantial control of vertigo (class B) in the remaining 2 patients (18%.) In the control group only 7 of 11 patients (64%) finished the 2\u2010year follow\u2010up because in the other 4 patients (36%) we had to give another treatment for the continuing vertigo and thus they were classified as failure (class F.) From the 7 patients who have finished the follow\u2010up of 2 years in the control group, 4 patients (57%) achieved class A, 2 patients (29%) achieved class C, and 1 patient (14%) class F.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions:<\/jats:title>\n                    <jats:p>Dexamethasone (4\u00a0mg\/mL) inner ear perfusion in a group of patients with unilateral M\u00e9ni\u00e8re's disease (Shea's stage III) showed 82% of complete control of vertigo over placebo (57%). There was also a subjective improvement in tinnitus (48%), hearing loss (35%), and aural fullness (48%) in the dexamethasone group compared with 20%, 10%, and 20% respectively in the control group.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>EBM Rating: A<\/jats:bold>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.otohns.2005.05.010","type":"journal-article","created":{"date-parts":[[2005,8,7]],"date-time":"2005-08-07T09:47:55Z","timestamp":1123408075000},"page":"285-294","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":185,"title":["Dexamethasone Inner Ear Perfusion by Intratympanic Injection in Unilateral M\u00e9ni\u00e8re's Disease: A Two\u2010year Prospective, Placebo\u2010Controlled, Double\u2010blind, Randomized Trial"],"prefix":"10.1002","volume":"133","author":[{"given":"Marco Antonio","family":"Gardu\u00f1o\u2010Anaya","sequence":"first","affiliation":[{"name":"Department of Neurotology Direction of Investigation National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helo\u00edsa Couthino","family":"De Toledo","sequence":"additional","affiliation":[{"name":"Department of Neurotology Direction of Investigation National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ram\u00f3n","family":"Hinojosa\u2010Gonz\u00e1lez","sequence":"additional","affiliation":[{"name":"Department of Neurotology Direction of Investigation National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlo","family":"Pane\u2010Pianese","sequence":"additional","affiliation":[{"name":"Department of Neurotology Direction of Investigation National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis Camilo","family":"R\u00edos\u2010Casta\u00f1eda","sequence":"additional","affiliation":[{"name":"Department of Neurotology Direction of Investigation National Institute of Neurology and Neurosurgery Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348947908800501"},{"key":"e_1_2_6_3_1","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1288\/00005537-199103000-00001","article-title":"M\u00e9ni\u00e8re's disease: an immune complex\u2010mediated illness?","volume":"101","author":"Dereberry ME","year":"1991","journal-title":"Laryngoscope"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1986.03780050060010"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199412000-00012"},{"key":"e_1_2_6_6_1","first-page":"96","article-title":"Immunologic testing of certain ear diseases.","volume":"6","author":"Yoo TJ","year":"1985","journal-title":"Am J Otol"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1177\/00034894840930S503"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949710600303"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199309000-00014"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199702000-00013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199110000-00009"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(96)70133-X"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489009122559"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556139607500809"},{"key":"e_1_2_6_15_1","first-page":"251","article-title":"Dexamethasone pharmacokinetics in the inner ear. 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