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Twenty subjects (14\u00a0males; 6 females) received 4\u00a0injections within a 2\u2010week period (4\u00a0days apart). Hearing, dizziness\/p, and tinnitus were evaluated before and after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results.<\/jats:title><jats:p>There were no serious unexpected adverse events and 2 types of expected adverse events (tympanic membrane perforation, nausea after injection). No increases in dizziness or tinnitus lasting longer than 24 hours were observed after injections. One of 20 (5%) improved to near\u2010normal hearing. In addition, there was statistically significant improvement in 4\u2010frequency pure\u2010tone average and speech discrimination score at 1\u00a0month after treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion.<\/jats:title><jats:p>Four intratympanic injections of methylprednisolone improved pure\u2010tone average or speech discrimination scores for a subset of sudden hearing loss subjects that failed to benefit from oral steroids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance.<\/jats:title><jats:p>A clinical trial of intratympanic injections for idiopathic sudden hearing loss was successfully completed and promising results were 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