{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T19:21:27Z","timestamp":1767986487669,"version":"3.49.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3911,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the short\u2010term effects of latanoprost, a selective FP prostanoid receptor agonist, in Meniere's disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND METHODS<\/jats:title><jats:p>Latanoprost was administered by intratympanic injection once daily for 3\u00a0days. Before the first injection (day 1) and on days 5 and 15, hearing and tinnitus were determined. The patients assessed vertigo on a visual analogue scale on days 1\u201015. The study was randomized, doubleblind, and placebo\u2010controlled.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Latanoprost reduced vertigo\/dysequilibrium around 30% (<jats:italic>P<\/jats:italic> &gt;0.05), and improved speech discrimination around 15% (<jats:italic>P<\/jats:italic> &gt;0.05). Tinnitus loudness deteriorated after injection of placebo (P &gt;0.01) but not after latanoprost. Side effects were few.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION AND SIGNIFICANCE<\/jats:title><jats:p>Latanoprost alleviated vertigo\/dysequilibrium and improved hearing. The results indicate that the drug potentially could be useful for treatment of Meniere's disease.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.05.043","type":"journal-article","created":{"date-parts":[[2005,9,7]],"date-time":"2005-09-07T15:58:28Z","timestamp":1126108708000},"page":"441-443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Effects of Intratympanic Injection of Latanoprost in Meniere's Disease: A Randomized, Placebo\u2010Controlled, Double\u2010Blind, Pilot Study"],"prefix":"10.1002","volume":"133","author":[{"given":"Helge","family":"Rask\u2010Andersen","sequence":"first","affiliation":[{"name":"Department of Otosurgery Department of Otolaryngology\u2010Head and Neck Surgery Uppsala University Hospital, Synphora AB Uppsala Sweden"},{"name":"Unit of Pharmacology Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulla","family":"Friberg","sequence":"additional","affiliation":[{"name":"Department of Otosurgery Department of Otolaryngology\u2010Head and Neck Surgery Uppsala University Hospital, Synphora AB Uppsala Sweden"},{"name":"Unit of Pharmacology Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Otosurgery Department of Otolaryngology\u2010Head and Neck Surgery Uppsala University Hospital, Synphora AB Uppsala Sweden"},{"name":"Unit of Pharmacology Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johan","family":"Stjernschantz","sequence":"additional","affiliation":[{"name":"Department of Otosurgery Department of Otolaryngology\u2010Head and Neck Surgery Uppsala University Hospital, Synphora AB Uppsala Sweden"},{"name":"Unit of Pharmacology Department of Neuroscience Uppsala University Uppsala Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.1999.79.4.1193"},{"key":"e_1_2_5_3_1","first-page":"1134","article-title":"From PGF2\u03b1\u2010isopropyl ester to latanoprost: a review of the development of Xalatan. The Proctor Lecture","volume":"42","author":"Stjernschantz JW","year":"2001","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_4_1","first-page":"41","volume-title":"Uveoscleral outflow. Biology and clinical aspects","author":"Lindsey JD","year":"1998"},{"key":"e_1_2_5_5_1","first-page":"716","article-title":"Localization of the prostaglandin F2a receptor messenger RNA and protein in cynomolgus monkey eye","volume":"37","author":"Ocklind A","year":"1996","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.04.018"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(85)90082-6"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(88)90085-8"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0194599805006601?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.05.043","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/api.elsevier.com\/content\/article\/PII:S0194599805006601?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.05.043","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.05.043","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:05:00Z","timestamp":1760969100000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.05.043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["10.1016\/j.otohns.2005.05.043"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.05.043","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,9]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}