{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T00:48:50Z","timestamp":1773276530207,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3820,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:sec><jats:title>BACKGROUND<\/jats:title><jats:p>Primary lymphoma of the thyroid gland is uncommon.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>The tumor registry at the Penn State Milton S. Hershey Medical Center was searched for all patients carrying a diagnosis of thyroid lymphoma. All available records for these patients were examined and information regarding patient and tumor characteristics, clinical presentation, interventions, and survival were tabulated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The average age of patient in our series was 67.5 years. There was a 2.7:1 female to male preponderance. Thirteen (60%) patients presented with thyroid nodule(s). Eleven (50%) presented with aerodigestive tract obstructive symptoms. Sixteen (73%) patients had no pre\u2010existing history of thyroid disease; none had known pre\u2010existing Hashimoto's thyroiditis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>The typical thyroid lymphoma patient is female and elderly with painless thyroid enlargement. Compressive symptoms of the aerodigestive tract are common at presentation and may require urgent intervention. Treatment modalities (XRT, CHOP chemotherapy) and outcomes are distinct from other thyroid malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>EBM RATING<\/jats:title><jats:p>C<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.07.040","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T10:21:35Z","timestamp":1135074095000},"page":"888-896","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["Thyroid Lymphoma: A Single Institution's Experience"],"prefix":"10.1002","volume":"133","author":[{"given":"Francis P.","family":"Ruggiero","sequence":"first","affiliation":[{"name":"Division of Otolaryngology Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center Hershey Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elizabeth","family":"Frauenhoffer","sequence":"additional","affiliation":[{"name":"Department of Pathology Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center Hershey Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"Brendan C.","family":"Stack","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology Pennsylvania State University College of Medicine and Milton S. Hershey Medical Center Hershey Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20010215)91:4<629::AID-CNCR1045>3.0.CO;2-Q"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.3109\/02841869609109922"},{"issue":"6","key":"e_1_2_13_5_1","first-page":"1166","article-title":"Malignant lymphoma of the thyroid gland: A clinical and pathologic study of 20 cases","volume":"98","author":"Rasbach DA","year":"1985","journal-title":"Surgery"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-99-5-685"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01657831"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0720-048X(02)00134-1"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198503073121001"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.1996.268311.x"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0360-3016(86)90324-X"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1991.01410340037006"},{"key":"e_1_2_13_13_1","first-page":"316","article-title":"Primary thyroid lymphoma","volume":"26","author":"Ansell SM","year":"1999","journal-title":"Semin Oncol"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02067333"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199810)19:4<260::AID-DC6>3.0.CO;2-E"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02573069"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2000.10.507"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004728-199503000-00021"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s005950170190"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.73.861.412"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0929-8266(98)00038-X"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0096(199706)25:5<279::AID-JCU11>3.0.CO;2-E"},{"key":"e_1_2_13_23_1","first-page":"1061","article-title":"Role of surgery in stage IE non\u2010Hodgkin's lymphoma of the thyroid","volume":"116","author":"Friedberg MH","year":"1994","journal-title":"Surgery"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19940101)73:1<200::AID-CNCR2820730135>3.0.CO;2-#"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.07.040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.07.040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.07.040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:51:30Z","timestamp":1760957490000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.07.040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,12]]},"references-count":23,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,12]]}},"alternative-id":["10.1016\/j.otohns.2005.07.040"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.07.040","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,12]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}