{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:35:21Z","timestamp":1761006921508,"version":"build-2065373602"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3820,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To determine the effects of combined radiation and targeted, intra\u2010arterial (IA) cisplatin infusions (RADPLAT) in patients with advanced squamous cell carcinoma (SCC) of the tonsil.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Prospective study of treatment outcomes and toxicity of patients enrolled on the RADPLAT protocol, with specific analysis of patients with advanced SCC of the tonsil.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Thirty patients with advanced tonsil carcinoma (17\u00a0T<jats:sub>4<\/jats:sub>, 12\u00a0T<jats:sub>3<\/jats:sub>, 1\u00a0T<jats:sub>2<\/jats:sub>) were enrolled, and 24 of 30 patients completed at least 3 IA cisplatin infusions and a minimum of 63\u00a0Gy or radiation therapy (minimum therapy). Two\u2010year estimated overall and disease\u2010specific survival was 42% and 50%, respectively, for all 30 patients (intent\u2010to\u2010treat group) and 49% and 58%, respectively, for the minimum therapy subgroup. The 2\u2010year estimated local and regional disease control was 87% and 90%, respectively, for the intent\u2010to\u2010treat group, and 100% and 90% for the minimum therapy subgroup. Functional organ preservation was achieved in 92% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Locoregional disease control achieved with this regimen appears to be significantly improved over that described in the literature for similarly staged tonsil cancer. Survival, on the other hand, remains comparable.<\/jats:p><\/jats:sec><jats:sec><jats:title>EBM RATING<\/jats:title><jats:p>C<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.08.014","type":"journal-article","created":{"date-parts":[[2005,12,20]],"date-time":"2005-12-20T10:21:35Z","timestamp":1135074095000},"page":"882-887","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Targeted Intra\u2010Arterial Chemoradiation for Advanced Tonsil Cancer"],"prefix":"10.1002","volume":"133","author":[{"given":"Srikanth I.","family":"Naidu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Tennessee Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francisco","family":"Vieira","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Tennessee Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Samant","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery University of Tennessee Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meng C.","family":"Vang","sequence":"additional","affiliation":[{"name":"Department of Radiology Division of Interventional Radiology University of Tennessee Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajim Y.","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Preventative Medicine University of Tennessee Memphis TN"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas K.","family":"Robbins","sequence":"additional","affiliation":[{"name":"Division of Otolaryngology\u2010Head and Neck Surgery Southern Illinois University School of Medicine Springfield 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