{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:35:18Z","timestamp":1789706118858,"version":"4.0.1"},"reference-count":14,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3789,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>We wished to correlate the expression of E\u2010cadherin and \u03b2\u2010catenin in squamous carcinomas of the head and neck to outcome and other clinicopathologic variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>This retrospective study was carried out in a tertiary care setting. The tumors of 45 patients who had their head and neck squamous carcinoma primarily treated by resection were evaluated immunohistochemically with antibodies to E\u2010cadherin and \u03b2\u2010catenin. Thirty\u2010two tumors arose in the oral cavity, 9 tumors originated in the larynx, and 4 tumors began in the hypopharynx. Patient outcome and the clinicopathologic variables of tumor site, tumor stage, cervical lymph node status, tumor differentiation, perineural invasion, and vascular invasion were correlated to immunohistochemical expression of E\u2010cadherin and \u03b2\u2010catenin.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Low expression of E\u2010cadherin in the tumors was significantly associated with decreased overall survival (<jats:italic>P<\/jats:italic> = 0.004), disease\u2010free survival (<jats:italic>P<\/jats:italic> = 0.007), and vascular invasion (<jats:italic>P<\/jats:italic> = 0.02) but not with other clinicopathologic variables. \u03b2\u2010catenin expression was not significantly associated with any of the studied clinicopathologic variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Decreased E\u2010cadherin but not \u03b2\u2010catenin expression is associated with decreased survival in patients with head and neck squamous carcinomas.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Detection of loss of E\u2010cadherin expression may help predict which patients with head and neck squamous cell carcinoma will experience a worse outcome compared to patients whose tumors have not lost this tumor suppressor.<\/jats:p><jats:p>EBM rating: C\u20104<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.08.026","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T07:11:08Z","timestamp":1136531468000},"page":"142-146","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":51,"title":["Decreased E\u2010Cadherin but not \u03b2\u2010Catenin Expression is Associated with Vascular Invasion and Decreased Survival in Head and Neck Squamous Carcinomas"],"prefix":"10.1002","volume":"134","author":[{"given":"Kevin A.","family":"Kurtz","sequence":"first","affiliation":[{"name":"Department of Pathology University of Iowa Iowa City Iowa"},{"name":"Department of Biostatistics University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry T.","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Iowa Iowa City Iowa"},{"name":"Department of Biostatistics University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Bridget","family":"Zimmerman","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Iowa Iowa City Iowa"},{"name":"College of Public Health University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Robinson","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Iowa Iowa City Iowa"},{"name":"Roy J. and Lucille A. Carver College of Medicine University of Iowa Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.10083"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.48.2.143"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0955-0674(93)90029-P"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-1004(1999)14:3<249::AID-HUMU8>3.0.CO;2-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800104"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1205528"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.275.5307.1787"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004320000177"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910550411"},{"key":"e_1_2_5_11_1","first-page":"1801","article-title":"Prediction of occult neck metastases in laryngeal carcinoma: Role of proliferating cell nuclear antigen, MIB\u20101, and E\u2010cadherin immunohistochemical determination","volume":"2","author":"Franchi A","year":"1996","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00399-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.5.512"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.54.1.42"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0714.2002.00108.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.08.026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.08.026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.08.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:34:02Z","timestamp":1760960042000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.08.026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":14,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1016\/j.otohns.2005.08.026"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.08.026","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}