{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,14]],"date-time":"2026-02-14T00:17:49Z","timestamp":1771028269231,"version":"3.50.1"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3789,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>Investigation of the potential role of several laryngopharyngeal reflux contents in sinus disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A controlled cohort analysis of <jats:italic>Helicobacter pylori<\/jats:italic>, pepsin and pepsinogen I in inflamed and non\u2010inflamed sinonasal tissue. Fifteen patients, selected for surgery due to chronic medically refractory rhinosinusitis, had their pathologic sinus tissue analyzed for polymerase chain reaction detection of <jats:italic>H. pylori<\/jats:italic> DNA and assayed for pepsin and pepsinogen I tissue concentration levels. A control group of 5 patients undergoing surgery for anatomic sinonasal abnormalities provided non\u2010inflammatory mucosa specimens for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>H. pylori<\/jats:italic> was found scattered in inflamed and non\u2010inflamed mucosa, whereas sinonasal tissue pepsin\/pepsinogen never rose above blood levels in both groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Evidence of intra\u2010operative peptic reflux into the sinuses was not found. As <jats:italic>H. pylori<\/jats:italic> was similarly encountered in healthy and diseased sinus mucosa, it seemingly fails to support a pathogenic role for this organism in the sinuses.<\/jats:p><jats:p>EBM rating: B\u20102b<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.10.013","type":"journal-article","created":{"date-parts":[[2006,1,6]],"date-time":"2006-01-06T07:11:08Z","timestamp":1136531468000},"page":"67-72","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["<i>Helicobacter Pylori<\/i> and Laryngopharyngeal Reflux in Chronic Rhinosinusitis"],"prefix":"10.1002","volume":"134","author":[{"given":"Paulo","family":"Borges Dinis","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology Hospital de Pulido Valente Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o","family":"Subtil","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Hospital de Pulido Valente Lisbon Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","first-page":"1","volume":"101","author":"Koufman JA","year":"1991","journal-title":"The otolaryngologic manifestations of gastroesophageal reflux disease (GERD): a clinical investigation of 225 patients using ambulatory 24\u2010hour pH monitoring and an experimental investigation of the role of acid and pepsin in the development of laryngeal injury Laryngoscope"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"Laryngopharyngeal reflux (LPR)","volume":"81","author":"Koufman JA","year":"2002","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-5876(91)90079-Q"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.7.831"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.MLG.0000163751.00885.63"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199704000-00014"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781389777"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2002.123857"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0030-6665(20)30414-X"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70181-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05598.x"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2001.119438"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200309000-00027"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/014556130508400417"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.4037\/ajcc2002.11.2.150"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/14.1.113"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/jcm.30.1.192-200.1992"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra020542"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200408263510924"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.013","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.10.013","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.013","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:34:08Z","timestamp":1760960048000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.10.013"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,1]]},"references-count":20,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1016\/j.otohns.2005.10.013"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.10.013","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,1]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}