{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,26]],"date-time":"2026-01-26T19:13:16Z","timestamp":1769454796787,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3638,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:sec><jats:title>OBJECTIVES<\/jats:title><jats:p>To define the oncologic efficacy of transoral endoscopic CO<jats:sub>2<\/jats:sub> laser surgery in early glottic carcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>A retrospective study of 103 patients with glottic carcinoma (14 Tis, 68\u00a0pT1a, 14\u00a0pT1b, and 7\u00a0pT2) treated from October 1993 to June 2001. Surgical treatment included endoscopic CO<jats:sub>2<\/jats:sub> laser cordectomies according to the classification of the European Laryngological Society.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>According to the Kaplan\u2010Meier method, the probability of remaining free of local recurrence 5 years after primary surgery alone was 100% for the Tis, 96.05% for the T1, and 100% for the T2. Local control at 5 years after exclusive CO<jats:sub>2<\/jats:sub> laser salvage surgery was 98.03%. The probability of remaining free of local recurrence 5 years after any type of salvage surgery was 100%. Laryngeal preservation was achieved in 100% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>According to the present series, endoscopic CO<jats:sub>2<\/jats:sub> laser surgery is an effective treatment for early glottic cancer.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.10.049","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T07:27:42Z","timestamp":1148628462000},"page":"911-915","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Carbon Dioxide Laser Microsurgery for Early Glottic Carcinoma"],"prefix":"10.1002","volume":"134","author":[{"given":"Gian","family":"Peppino Ledda","sequence":"first","affiliation":[{"name":"Department of Surgical Sciences and Organ Transplantations Section of Otorhinolaryngology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Puxeddu","sequence":"additional","affiliation":[{"name":"Department of Surgical Sciences and Organ Transplantations Section of Otorhinolaryngology University of Cagliari Cagliari Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004050050228"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199711000-00015"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1177\/030089160008600403"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949110000111"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-0709(97)90058-2"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200402000-00012"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0892-1997(98)80084-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949810700213"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200301000-00013"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949410300104"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000404"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940311200212"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2003.07.002"},{"key":"e_1_2_6_15_1","first-page":"41","volume-title":"American Joint Committee on Cancer","author":"Fleming ID","year":"1997"},{"key":"e_1_2_6_16_1","first-page":"119","article-title":"Intrinsic carcinoma of the larynx with a second report of cases operated on by suspension and dissection","volume":"42","author":"Lynch RC","year":"1920","journal-title":"Trans Am Laryngol Assoc"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-197508000-00003"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000102"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198404000-00012"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1972.00770080372009"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199807000-00010"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.049","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.10.049","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.049","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T08:56:30Z","timestamp":1760950590000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.10.049"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,6]]}},"alternative-id":["10.1016\/j.otohns.2005.10.049"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.10.049","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,6]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}