{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T04:20:47Z","timestamp":1789878047606,"version":"4.0.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Advanced\u2010stage oropharyngeal cancer may be treated either surgically or nonsurgically. We reported previously functional outcomes after surgical resection with free\u2010tissue transfer. In the present study, we evaluated swallowing function after combined chemoradiation for oropharyngeal cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Retrospective review of 30 patients treated at a tertiary academic center for Stage III\/IV oropharyngeal cancer with sequential or concurrent chemoradiation from 1994 to 2003.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Inclusion criteria were met by 27 of 30 (90%) patients. Most patients had base of tongue lesions (67%) and Stage IV disease (93%). Gastrostomy was carried out in 22 (82%) patients either before or during treatment. Three months after chemoradiation, 33% (9\/27) were consuming all nutrition orally, 22% (6 of 27) were NPO, and 45% (12 of 27) had some oral intake but still required tube feeds. One year after treatment, 53% (10 of 19) had an exclusively oral diet whereas 47% still required tube feeds including 1 patient (5%) who was NPO. In patients without recurrence and follow\u2010up length &gt;1 year, 69% (9 of 13) were consuming all nutrition orally whereas 31% still required gastrostomy tube (G\u2010tube) support. A higher rate of G\u2010tube dependence was observed in patients treated for base of tongue lesions vs tonsil lesions (67% vs 25%, <jats:italic>P<\/jats:italic> = 0.049, \u03c7<jats:sup>2<\/jats:sup> analysis).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>At this institution, the short\u2010term (3\u20104\u00a0months) rate of G\u2010tube dependence was similar after surgical and non\u2010surgical treatment of oropharyngeal cancer. One year after chemoradiation, 31% of patients without recurrence still required tube feeds.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>These results suggest that organ\u2010preservation protocols do not reduce the prevalence of chronic dysphagia and G\u2010tube dependence after management of oropharyngeal cancer.<\/jats:p><jats:p>EBM rating: C\u20104<\/jats:p><jats:p>\u00a9 2006 American Academy of Otolaryngology\u2013Head and Neck Surgery Foundation, Inc. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.10.054","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:28:35Z","timestamp":1140593315000},"page":"455-459","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":101,"title":["Swallowing Function after Chemoradiation for Advanced Stage Oropharyngeal Cancer"],"prefix":"10.1002","volume":"134","author":[{"given":"Samuel G.","family":"Shiley","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Oregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher A.","family":"Hargunani","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Oregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Judith M.","family":"Skoner","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Oregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Holland","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Oregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark K.","family":"Wax","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Oregon Health &amp; Science University Portland OR"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","volume-title":"Cancer facts and figures 2002.","author":"American Cancer Society.","year":"2002"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1995.01890090018003"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199806183382503"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.7.1458"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000901)89:5<939::AID-CNCR1>3.0.CO;2-6"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0347(200010)22:7<687::AID-HED8>3.0.CO;2-W"},{"key":"e_1_2_6_8_1","first-page":"140","article-title":"Induction chemotherapy followed by concomitant chemoradiotherapy in the treatment of locoregionally advanced oropharyngeal cancer.","volume":"7","author":"Mantz CA","year":"2001","journal-title":"Cancer J"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajot.2001.26492"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.20.5.1405"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.11.026"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.06.006"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200305000-00023"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1997.01900070075012"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200308000-00005"},{"key":"e_1_2_6_16_1","first-page":"1685","article-title":"The Department of Veterans Affairs Laryngeal Cancer Study Group.","volume":"324","author":"Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer.","year":"1991","journal-title":"N Engl J Med"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199609000-00021"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/hed.10000"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0360-3016(02)02712-8"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200303000-00033"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19900801)66:3<564::AID-CNCR2820660326>3.0.CO;2-D"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.124.5.589"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0347(199910)21:7<595::AID-HED2>3.0.CO;2-J"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.054","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.10.054","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.054","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:24:40Z","timestamp":1760966680000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.10.054"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":22,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1016\/j.otohns.2005.10.054"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.10.054","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}