{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:43:31Z","timestamp":1779335011410,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3730,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,3]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>This study describes a large series of patients receiving topical mitomycin\u2010c (MMC) during airway surgery, including complications, and carries out a cost analysis for its use in laryngotracheal stenosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Retrospective review, tertiary center. Airway patients receiving MMC are reviewed for demographics, stenosis characteristics, and MMC usage. A basic cost analysis is carried out.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Fifty patients underwent 93\u00a0MMC applications (mean = 50.8 years, 25\u00a0male, 25 female). In 89 of 93 applications (96%), the concentration of MMC was 0.4\u00a0mg\/ml. One major complication occurred (1.1%). The expense for MMC is $455; the mean cost for airway surgery is $7,840. It is estimated that if 1 of 17\u00a0MMC treated patients requires one less operation, the cost ratio is favorable.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This large series contributes to literature that MMC is a safe adjunct to laryngotracheal surgery. The marginal cost for MMC application is favorable based on our basic cost analysis and existing efficacy data.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Mitomycin\u2010c seems to be safe and cost\u2010effective in endoscopic airway surgery.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.10.057","type":"journal-article","created":{"date-parts":[[2006,2,22]],"date-time":"2006-02-22T07:28:35Z","timestamp":1140593315000},"page":"403-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":55,"title":["Mitomycin\u2010c Application in Airway Stenosis Surgery: Analysis of Safety and Costs"],"prefix":"10.1002","volume":"134","author":[{"given":"Matthew L.","family":"Ubell","sequence":"first","affiliation":[{"name":"Department of Otolaryngology and Communications Sciences Medical College of Wisconsin Milwaukee WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandra L.","family":"Ettema","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communications Sciences Medical College of Wisconsin Milwaukee WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert J.","family":"Toohill","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communications Sciences Medical College of Wisconsin Milwaukee WI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Blake","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery University of Texas Health Science Center at San Antonio San Antonio TX"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert L.","family":"Merati","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology and Communications Sciences Medical College of Wisconsin Milwaukee WI"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1052-3359(03)00002-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988609500508"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198510000-00015"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948209100412"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348948709600609"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31781-6"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1992.01080200130040"},{"key":"e_1_2_6_9_1","first-page":"2136","article-title":"Effects of mitramycin, mitomycin, daunorubicin and bleomycin on human subconjunctival fibroblasts attachment and proliferation.","volume":"31","author":"Lee DA","year":"1990","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(96)30635-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(92)31750-6"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-5998(99)70316-5"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199806000-00017"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199907000-00022"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001103"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000105"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199910000-00009"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949910801106"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111000101"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2004.03.001"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otohns.2005.07.031"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.057","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.10.057","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.10.057","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:24:39Z","timestamp":1760966679000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.10.057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["10.1016\/j.otohns.2005.10.057"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.10.057","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,3]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}