{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:40:55Z","timestamp":1777394455452,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3699,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,4]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Determine presentation and survival rates for malignant pediatric salivary gland neoplasms.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>All cases of malignant neoplasms involving the parotid or submandibular gland in patients ages birth to 18 years were extracted from the Surveillance, Epidemiology, and End Results database (1988\u20132001). Variables included age, gender, tumor histology, size, follow\u2010up time, and vital status. Kaplan\u2010Meier survival curves were constructed.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>113 primary salivary gland malignancies (103 parotid, 10 submandibular) were identified. Mean age at presentation was 13.2 years. Female:male ratio of 5:4. Mean tumor size was 2.5\u00a0cm. Among parotid tumors, there were 44 (43%) mucoepidermoid carcinomas and 35 (34%) acinic cell carcinomas. At a mean follow\u2010up of 69.4\u00a0months, 6 (5.8%) patients with parotid malignancy were deceased; none of the submandibular malignancies were fatal. Mean Kaplan\u2010Meier survival for parotid gland lesions was 153\u00a0months, with rhabdomyosarcomas exhibiting significantly worse survivals as compared to other malignancies <jats:italic>(P &lt;<\/jats:italic> 0.001, log\u2010rank test).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Both epithelial and mesenchymal tumors present in the pediatric salivary gland. Survival for both parotid and submandibular gland malignancies is good in children.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2005.11.018","type":"journal-article","created":{"date-parts":[[2006,3,28]],"date-time":"2006-03-28T07:10:13Z","timestamp":1143529813000},"page":"631-634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":89,"title":["Clinical Characteristics and Survival for Major Salivary Gland Malignancies in Children"],"prefix":"10.1002","volume":"134","author":[{"given":"Nina L.","family":"Shapiro","sequence":"first","affiliation":[{"name":"Division of Head and Neck Surgery UCLA School of Medicine Los Angeles California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil","family":"Bhattacharyya","sequence":"additional","affiliation":[{"name":"Department of Otology and Laryngology Harvard Medicial School Division of Otolaryngology Brigham and Women's Hospital Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"BriggerMT PearsonSEManagement of parapharyngeal minor salivary neoplasms in children: A case report and review.Int J Pediatr Otorhinolaryngol2005(in press)."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1368-8375(00)00033-6"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijporl.2004.02.004"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.1985.00800070074011"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.128.8.904"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mlg.0000154743.71184.09"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1067\/mhn.2003.2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2003.06.012"},{"key":"e_1_2_6_10_1","unstructured":"http:\/\/www.seer.gov\/about\/."},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.126.2.177"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6109(16)43829-6"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/mpo.10168"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000715)89:2<463::AID-CNCR35>3.0.CO;2-R"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90668-6"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjoto.2004.06.017"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459988910100510"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-3468(94)90520-7"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joms.2005.03.006"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21083"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198610000-00014"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.11.018","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2005.11.018","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2005.11.018","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:25:33Z","timestamp":1760955933000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2005.11.018"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4]]},"references-count":20,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,4]]}},"alternative-id":["10.1016\/j.otohns.2005.11.018"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2005.11.018","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}