{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,4]],"date-time":"2026-04-04T12:17:06Z","timestamp":1775305026855,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The pathogenesis of sinonasal polyposis (SNP) is not clear; it has been suggested that it is polygenic and multifactorial. The major histocompatibility complex is a useful tool to predict genetic susceptibility to diseases, especially to autoimmune diseases. Since such susceptibility is influenced by ethnicity, it is necessary to have a wide knowledge of the structure of the population to which the patient belongs. The purpose of the study was to determine the association of HLA\u2010DRB1 alleles with sinonasal polyposis in the Mexican Mestizo population.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>We studied the HLA\u2010DR alleles in 34 adult Mexican Mestizo patients with SNP and compared them to those present in 99 healthy controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Genomic DNA from mononuclear cells was obtained by using the \u201csalting out\u201d technique and high\u2010resolution DNA typing of the HLA\u2010DRB1 alleles was performed after PCR amplification.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>We found a statistically significant increased frequency of the HLA\u2010DRB1<jats:sup>\u2217<\/jats:sup>03 allele (<jats:italic>P<\/jats:italic> = 0.03, odds ratio [OR] = 2.9, 95% confidence interval [CI]: 1.0\u20137.8) and of the HLA\u2010DRB1<jats:sup>\u2217<\/jats:sup>04 allele (<jats:italic>P<\/jats:italic> = 0.009, OR = 2.2, 95% CI: 1.2\u20134.2) in patients with SNP as compared to controls, and a statistically significant decreased frequency of the HLA\u2010DRB1<jats:sup>\u2217<\/jats:sup>08 allele (<jats:italic>P<\/jats:italic> = 0.01, OR = 0.2, 95% CI: 0.05\u20130.8).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The HLA\u2010DR locus seems to be associated with the genetic susceptibility to develop SNP in Mexicans.<\/jats:p><jats:p>EBM rating: B\u20102b<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.01.009","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T09:40:19Z","timestamp":1151746819000},"page":"90-93","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of HLA\u2010DR3 and HLA\u2010DR4 with Sinonasal Polyposis in Mexican Mestizos"],"prefix":"10.1002","volume":"135","author":[{"given":"Ram\u00edrez\u2010Anguiano","family":"Jaqueline","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K. Yamamoto\u2010Furusho","family":"Jes\u00fas","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumathology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barquera","family":"Rodrigo","sequence":"additional","affiliation":[{"name":"Facultad de Qu\u00edmica Universidad Aut\u00f3noma de Mexico Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beltr\u00e1n","family":"Olga","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Granados","family":"Julio","sequence":"additional","affiliation":[{"name":"Department of Immunology and Rheumathology Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0194-59989570012-9"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2500\/105065899781367537"},{"key":"e_1_2_7_4_1","first-page":"317","article-title":"Multifactorial etiology of nasal polyps","volume":"46","author":"Small P","year":"1981","journal-title":"Ann Allergy"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1997.tb00709.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00179379"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-6749(77)90171-3"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2273.1980.tb02132.x"},{"key":"e_1_2_7_9_1","first-page":"500","article-title":"Primary nasal polyposis","volume":"51","author":"Jacobs 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