{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T04:19:27Z","timestamp":1775881167080,"version":"3.50.1"},"reference-count":16,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3669,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Evaluate possible role of <jats:italic>Helicobacter Pylori<\/jats:italic> in pathogenesis of otitis media with effusion (OME).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Randomized controlled trial, tertiary referral center.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY GROUP<\/jats:title><jats:p>Middle ear fluid was aspirated, a biopsy was taken from the promontorium of 22 children with OME.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONTROL GROUP<\/jats:title><jats:p>A small biopsy was taken from the promontorium of 20 children with normal otologic findings. For both groups, 5\u00a0mm deep tissue specimens were obtained from tonsil and adenoid.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p><jats:italic>H pylori<\/jats:italic> presence in the middle ear, the tonsillar and adenoid tissues by culture and PCR was significantly more frequent in the study group compared to the control group (<jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study is the first to grow <jats:italic>H pylori<\/jats:italic> in middle ear in OME. Significantly increased colonization by <jats:italic>H pylori<\/jats:italic> of the middle ear, and tonsillar and adenoid tissue in patients with OME indicates that the bacteria might be involved in the pathogenesis of OME.<\/jats:p><jats:p>EBM rating: A\u20101b<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.02.002","type":"journal-article","created":{"date-parts":[[2006,5,3]],"date-time":"2006-05-03T09:21:07Z","timestamp":1146648067000},"page":"772-777","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":42,"title":["<i>Helicobacter Pylori: A<\/i> Possible Association with Otitis Media with Effusion"],"prefix":"10.1002","volume":"134","author":[{"given":"Taner","family":"Yilmaz","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mehmet","family":"Ceylan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yakut","family":"Aky\u00fcn","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olcay","family":"\u00d6z\u00e7ak\u00fdr","sequence":"additional","affiliation":[{"name":"Department of Microbiology and Clinical Microbiology Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B\u00fclent","family":"G\u00fcrsel","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery Hacettepe University Faculty of Medicine Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200211000-00004"},{"key":"e_1_2_5_3_1","volume-title":"Current protocols in molecular biology","author":"Wilson K","year":"1987"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000139071.30956.30"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07116.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202760230810"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/003655202320621391"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200304000-00018"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00021"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200206000-00004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348940111001007"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.2002.tb07625.x"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/00129492-200107000-00005"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-5876(00)00396-7"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200112000-00018"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/000348949009900607"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1536-4801.1998.tb01294.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.002","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.02.002","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.002","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T11:30:24Z","timestamp":1760959824000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.02.002"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1016\/j.otohns.2006.02.002"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.02.002","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}