{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:41:57Z","timestamp":1761154917914,"version":"build-2065373602"},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3608,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To examine the effects of estrogen suppression on age\u2010related changes in distortion product otoacoustic emissions (DPOAEs) and contralateral suppression (CS) of DPOAEs in CBA mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Young CBA mice received a slow\u2010release shoulder implantation of either tamoxifen or placebo. Serial DPOAEs and CS of DPOAEs were obtained at 3\u2010week intervals over a period of 9 weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Although DPOAEs were maintained over the study interval, CS of DPOAEs decreased significantly with age in the experimental group. No such declines were observed in either the control animals or the untreated male mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>Estrogen suppression negatively affects the MOC efferent feedback system.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Our results support the hypothesis that estrogen plays an important role in the maintenance of auditory integrity. Additionally, our findings raise intriguing questions about auditory effects of hormonal shifts in humans resulting from menopause, hormone supplements such as oral contraceptives, and hormone replacement therapy as well as antiestrogens.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.02.004","type":"journal-article","created":{"date-parts":[[2006,7,1]],"date-time":"2006-07-01T09:40:19Z","timestamp":1151746819000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Estrogen Blockade Reduces Auditory Feedback in CBA Mice"],"prefix":"10.1002","volume":"135","author":[{"given":"K. Scott","family":"Thompson","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhu","family":"Xiaoxia","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. Robert","family":"Frisina","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2014Head and Neck Surgery University of Rochester School of Medicine and Dentistry Rochester New York"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_18_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199004000-00005"},{"key":"e_1_2_18_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00003446-199712000-00003"},{"key":"e_1_2_18_4_1","first-page":"59","article-title":"Age dependence of otoacoustic emissions and apparent rates of aging of inner ear in an Australian population","volume":"15","author":"Murray M","year":"1993","journal-title":"Austral J Audiol"},{"key":"e_1_2_18_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000066159"},{"key":"e_1_2_18_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200310000-00009"},{"key":"e_1_2_18_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(87)90166-3"},{"key":"e_1_2_18_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90127-5"},{"key":"e_1_2_18_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(89)90032-4"},{"key":"e_1_2_18_10_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1987.57.4.1002"},{"key":"e_1_2_18_11_1","doi-asserted-by":"publisher","DOI":"10.1121\/1.414734"},{"key":"e_1_2_18_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(94)90248-8"},{"key":"e_1_2_18_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016489109100753"},{"key":"e_1_2_18_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/0378-5955(95)00045-6"},{"key":"e_1_2_18_15_1","first-page":"726","article-title":"The association between serum estradiol level and hearing sensitivity in postmenopausal women","volume":"5","author":"Kim SH","year":"2002","journal-title":"Obstet Gynecol"},{"key":"e_1_2_18_16_1","article-title":"Sex differences in age\u2010related decline of the auditory efferent system in CBA mice","author":"Zhu X","year":"2004","journal-title":"Assoc Res Otolaryngol"},{"key":"e_1_2_18_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heares.2004.01.013"},{"key":"e_1_2_18_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(99)00098-2"},{"key":"e_1_2_18_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0018-506X(92)90020-V"},{"key":"e_1_2_18_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5955(03)00136-9"},{"key":"e_1_2_18_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(05)80415-0"},{"key":"e_1_2_18_22_1","first-page":"27","article-title":"Hormone replacement therapy negatively affects hearing in aged women","author":"Guimar\u00e3es P","year":"2004","journal-title":"Assoc Res Otolaryngology"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.004","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.02.004","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.004","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:42:23Z","timestamp":1760956943000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.02.004"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,7]]}},"alternative-id":["10.1016\/j.otohns.2006.02.004"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.02.004","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"type":"print","value":"0194-5998"},{"type":"electronic","value":"1097-6817"}],"subject":[],"published":{"date-parts":[[2006,7]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}