{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:46:03Z","timestamp":1761007563738,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>In an attempt to identify molecular markers predictive of occult neck metastases, we investigated whether positive p53 or proliferating cell nuclear antigen (PCNA) immunoreactivities on deparaffinized sections of the primary tumor are correlated to the presence of occult neck node metastases in oral tongue cancer patients with clinically negative cervical nodes (N0).<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Between 1986 and 1997, 37 clinically N0 patients who underwent neck dissection (25\u00a0male, 12 female; mean age 54 years) were selected for p53 and PCNA staining.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>p53 and PCNA immunoreactivities were detected in 68% and 32%, respectively. There was no correlation between p53 or PCNA and other clinicopathological factors, such as tumor differentiation, tumor type, tumor size, and T\u2010stage. Although tumor differentiation (<jats:italic>P<\/jats:italic> = 0.03) and tumor size (<jats:italic>P<\/jats:italic> = 0.03) were significantly correlated with occult neck metastases of oral tongue cancer by univariate analysis, no correlation was found between p53 or PCNA and the presence of occult neck metastasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>p53\u00a0and\/or PCNA expression are unsuitable as biological markers predictive of lymph node metastases of oral tongue cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>p53\u2010 or PCNA\u2010positive status are not a reliable parameter for selection of elective neck dissection in the management of N0 oral tongue cancer patients.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.02.011","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T09:44:54Z","timestamp":1164879894000},"page":"858-864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Predictive value of p53 and PCNA expression for occult neck metastases in patients with clinically node\u2010negative oral tongue cancer"],"prefix":"10.1002","volume":"135","author":[{"given":"Ki Chang","family":"Keum","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Ji","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology National Health Insurance Cooperation Ilsan Hospital Kyonggi Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woong Sub","family":"Koom","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sang Ho","family":"Cho","sequence":"additional","affiliation":[{"name":"Department of Pathology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Chang","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Geol","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang Ok","family":"Suh","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gwi Eon","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Yonsei Cancer Center Brain Korea 21\u00a0Project for Medical Science Yonsei University College of Medicine Seoul 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