{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T23:55:15Z","timestamp":1791330915508,"version":"4.3.1"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>PROBLEM<\/jats:title><jats:p>To provide a less expensive and more convenient protocol for the treatment of tympanic membrane perforations (TMPs).<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>Several materials were prepared and compared for TMP repair including Carbylan\u2010SX, Gelatin\u2010DTPH\u2010PEGDA (GX), Carbylan\u2010S\/Gelatin\u2010DTPH (Carbylan\u2010GSX) (injectable and sponge), Gelfoam, Epifilm, and crosslinked thiolated chondroitin sulfate (CS\u2010DTPH\u2010PEGDA [CS\u2010SX]). Hartley pigmented guinea pigs (Elm Hill) underwent bilateral myringotomy with 1 ear left as a control and the other treated with one of the previously mentioned materials.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Carbylan\u2010GSX (injectable and sponge), Gelfoam with saline, and CS\u2010SX had the shortest time for TMP closure. Epifilm, Carbylan, and gelatin preparations resulted in closure rates similar to controls. CS\u2010SX showed a marked inflammatory reaction compared with controls and other materials based on neutrophil, lymphocyte, epitheloid counts, and degree of fibrosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSIONS<\/jats:title><jats:p>This study shows the validity of Carbylan\u2010GSX compared with Gelfoam as a material to promote TMP closure in an acute TMP guinea pig model.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.02.040","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T09:44:54Z","timestamp":1164879894000},"page":"877-883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Crosslinked hydrogels for tympanic membrane repair"],"prefix":"10.1002","volume":"135","author":[{"given":"Albert H.","family":"Park","sequence":"first","affiliation":[{"name":"Division of Otolaryngology\u2013Head and Neck Surgery University of Utah Salt Lake City Utah"},{"name":"Center for Therapeutic Biomaterials University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Casey W.","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Bioengineering University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne","family":"Jackson","sequence":"additional","affiliation":[{"name":"Communicative Sciences and Disorders and Animal Reference Pathology University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Hunter","sequence":"additional","affiliation":[{"name":"Communicative Sciences and Disorders and Animal Reference Pathology University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence","family":"McGill","sequence":"additional","affiliation":[{"name":"Division of Associated Regional and University Pathologists, Inc Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara Ellis","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Family and Preventive Medicine University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen C.","family":"Alder","sequence":"additional","affiliation":[{"name":"Family and Preventive Medicine University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Zheng","family":"Shu","sequence":"additional","affiliation":[{"name":"Center for Therapeutic Biomaterials University of Utah Salt Lake City Utah"},{"name":"Department of Medicinal Chemistry University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn D.","family":"Prestwich","sequence":"additional","affiliation":[{"name":"Center for Therapeutic Biomaterials University of Utah Salt Lake City Utah"},{"name":"Department of Bioengineering University of Utah Salt Lake City Utah"},{"name":"Department of Medicinal Chemistry University of Utah Salt Lake City Utah"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100084346"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016487009181875"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215100071644"},{"key":"e_1_2_5_5_1","first-page":"163","article-title":"Tympanic membrane retraction pocket","volume":"49","author":"Ars B","year":"1995","journal-title":"Acta Otolaryngol Belg"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(02)00100-X"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.BCR.0000124790.69026.3D"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0142-9612(03)00267-9"},{"key":"e_1_2_5_9_1","first-page":"125","volume-title":"Injectable synthetic extracellular matrices for tissue engineering and repair","author":"Prestwich G","year":"2006"},{"key":"e_1_2_5_10_1","volume-title":"Modified macromolecules and methods of making and using thereof","author":"Prestwich GD","year":"2004"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm025603c"},{"key":"e_1_2_5_12_1","first-page":"1139","article-title":"In situ crosslinkable hyaluronan hydrogels for tissue engineering","volume":"25","author":"Shu XZ","year":"2004","journal-title":"Biomaterials"},{"key":"e_1_2_5_13_1","unstructured":"DufloS ThibeaultSL LiW et al.Vocal fold tissue repair in vivo using a synthetic extracellular matrix.Tissue Eng(in press)."},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.a.10142"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/jor.20148"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1006\/scdb.2000.0243"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000276182"},{"key":"e_1_2_5_18_1","first-page":"468","article-title":"Use of a hyaluronan\u2010based biomembrane in the treatment of chronic cholesteatomatous otitis media","volume":"21","author":"Martini A","year":"2000","journal-title":"Am J Otol"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.127.5.534"},{"key":"e_1_2_5_20_1","volume-title":"Esterified hyaluronan (Oto\u2010sponge) in the middle ear: A new tool for otosurgery?","author":"Laurent C","year":"1996"},{"key":"e_1_2_5_21_1","first-page":"43","volume-title":"Cholesteatoma and mastoid surgery: proceeding of the Fifth International Conference on Cholesteatoma and Mastoid Surgery, Alghero, Sardinia Fifth International Conference on Cholesteatoma and Mastoid Curgery","author":"Martini A","year":"1996"},{"key":"e_1_2_5_22_1","first-page":"336","article-title":"Sensorineural hearing loss following stapedectomy. Acta Otolaryngol","volume":"54","author":"Schuknecht H","year":"1962","journal-title":"(Stockh)"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-196211000-00003"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000275219"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.3109\/00016488309132899"},{"key":"e_1_2_5_26_1","first-page":"27","article-title":"Fibrin glue reinforced paper patch myringoplasty of large persisten tympanic membrane perforations in the guinea pig model. Otorhinolaryngol","volume":"58","author":"DiLeo M","year":"1996","journal-title":"Res"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.040","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.02.040","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.02.040","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T14:13:17Z","timestamp":1760969597000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.02.040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":25,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["10.1016\/j.otohns.2006.02.040"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.02.040","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}