{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T17:23:55Z","timestamp":1790616235989,"version":"4.1.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3577,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to determine the contribution of the human major histocompatibility complex (HLA)\u2010DQA1, \u2010DQB1, and TNF\u0391 genes with simple nasal polyposis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p>A comparative case\u2010control study with 31 patients and 151 controls was performed. HLADQA1, \u2010DQB1, and TNF\u0391 \u2212238 promoter position loci were typed by polymerase chain reaction (PCR) and sequence specific oligonucleotide probes (SSOPs). TNF\u0391 \u2112308 promoter position was determined by PCR and digestion with NcoI restriction enzyme.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The allele HLA\u2010DQA1*0201 (<jats:italic>P<jats:sub>c<\/jats:sub><\/jats:italic> = 0.019) had an etiologic fraction (EF) of 17%, whereas 13% EF was found for the haplotype HLA\u2010DQA1*0201\u2010DQB1*0201 (<jats:italic>P<\/jats:italic> = 0.016). Analysis of \u2010DQB1 and TNF\u0391 promoter did not show significant differences between cases and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HLA\u2010DQA1*0201\u2010DQB1*0201 haplotype is involved in susceptibility, conferring 5.53 times more risk of developing this disease.<\/jats:p><jats:p><jats:bold>EBM rating: B\u22122b<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.03.034","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T10:36:57Z","timestamp":1154947017000},"page":"243-247","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["DQA1 and DQB1 association and nasal polyposis"],"prefix":"10.1002","volume":"135","author":[{"given":"Germ\u00e1n","family":"Fajardo\u2010Dolci","sequence":"first","affiliation":[{"name":"Clinical Division of Otorhynolaryngology Hospital General \u201cDr. Manuel Gea Gonz\u00e1lez,\u201d SSA 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