{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:39:33Z","timestamp":1792168773993,"version":"4.4.0"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3577,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,8]]},"abstract":"Objectives<\/jats:title>To compare the efficacy and side effects of frozen versus fresh reconstituted botulinum toxin type A (BTX\u2010A) in the treatment of laryngeal dystonia.<\/jats:p><\/jats:sec>Study Design and Setting<\/jats:title>Prospective open\u2010label crossover study; 43 adult patients with adductor spasmodic dysphonia were randomly treated with fresh or refrozen reconstituted BTX\u2010A at a private voice center. Treatment outcomes were assessed by duration of action and self\u2010rated satisfaction (7 point Likert scale). Side effects of breathiness and dysphagia for liquids were assessed as well.<\/jats:p><\/jats:sec>Results<\/jats:title>There was no statistically significant difference in the duration of action (mean, 16.2 \u00b1 8.5 vs 16.0 \u00b1 7.6 weeks) and self\u2010rated satisfaction of the treatment (median, 6.0 vs 6.0 points). The side effects were similar for both BTX\u2010A injection types. In addition, there were no instances of infection for refrozen injections.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>BTX\u2010A may be safely used after being reconstituted and frozen or refrozen without a significant loss of effectiveness or additional side effects. In our experience, the period of freezing was on 2 occasions for up to 8 weeks.<\/jats:p><\/jats:sec>Significance<\/jats:title>Refrozen BTX\u2010A may be a cost\u2010effective use of an expensive drug.<\/jats:p>EBM rating: B\u20102b<\/jats:bold><\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.04.001","type":"journal-article","created":{"date-parts":[[2006,8,7]],"date-time":"2006-08-07T10:36:57Z","timestamp":1154947017000},"page":"204-208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Frozen versus fresh reconstituted botox for laryngeal dystonia"],"prefix":"10.1002","volume":"135","author":[{"given":"James P.","family":"Thomas","sequence":"first","affiliation":[{"name":"Portland Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nora","family":"Siupsinskiene","sequence":"additional","affiliation":[{"name":"Kaunas Medical University Hospital ENT Department Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-199810000-00003"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archotol.130.4.415"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajhp\/61.suppl_6.S24"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.PRS.0000061003.68203.56"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.48.1.249"},{"key":"e_1_2_7_7_1","first-page":"523","article-title":"Multicenter, double\u2010blind study of the efficacy of injections with Botulinum toxin type A reconstituted up to six consecutive weeks before application","volume":"29","author":"Hexel DM","year":"2003","journal-title":"Dermatol Surg"},{"key":"e_1_2_7_8_1","first-page":"411","article-title":"Factors leading to successful evaluation and management of patients with voice disorders","volume":"67","author":"Bastian RW","year":"1988","journal-title":"Ear Nose Throat J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0967-5868(03)00020-1"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.moo.0000145959.50513.5e"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1177\/019459989310800205"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.1996.tb00569.x"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jvoice.2000.11.001"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.04.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.04.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.04.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T13:50:34Z","timestamp":1760968234000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.04.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1016\/j.otohns.2006.04.001"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.04.001","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,8]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}