{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:09:51Z","timestamp":1787771391564,"version":"build-2784847793"},"reference-count":14,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3546,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,9]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate the findings of computed tomography (CT) and histopathology of the bulla ethmoidalis as objective markers of bone remodeling in chronic rhinosinusitis (CRS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Preoperative ostiomeatal unit (OMU) scans and histopathologic findings of the bulla ethmoidalis were performed on 23 patients (39 sides) undergoing endoscopic sinus surgery for CRS. Lund\u2010Mackay scores and Hounsfield units (HU) of the bulla were checked in coronal CT scans. The pathologist graded the severities of the mucosal and bony changes in histopathology. Statistical analysis was performed using Mann\u2010Whitney U test and Spearman correlation coefficient (r).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HU values of the bulla were significantly increased with higher Lund\u2010Mackay scores in OMU CT (r = 0.405, <jats:italic>P<\/jats:italic> = 0.01). The bony grades in histopathology were significantly increased with higher mucosal grades (r = 0.821, <jats:italic>P<\/jats:italic> = 0.0001). These findings in CT scans and histopathology were well correlated with each other (r &gt; 0.3, <jats:italic>P<\/jats:italic> &lt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>HU may be a useful objective marker of bone remodeling in chronic rhinosinusitis.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.04.005","type":"journal-article","created":{"date-parts":[[2006,9,2]],"date-time":"2006-09-02T07:22:32Z","timestamp":1157181752000},"page":"404-408","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":65,"title":["CT analysis and histopathology of bone remodeling in patients with chronic rhinosinusitis"],"prefix":"10.1002","volume":"135","author":[{"given":"Seok Hyun","family":"Cho","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery School of Medicine Hanyang University Seoul 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