{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T15:27:10Z","timestamp":1768750030038,"version":"3.49.0"},"reference-count":8,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3485,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>To determine the correlation between methylene blue use and toxic metabolic encephalopathy in patients undergoing surgery for primary hyperparathyroidism.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>A retrospective study of 193 patients was performed to collect demographic, perioperative, and postoperative data. Patients were divided into two groups: Group A (postoperative neurological sequelae) and Group B (no neurological sequelae). All data points were compared between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Twelve of 193 patients were placed in Group A; 181 patients were placed in Group B. Ten patients in Group A were female, and 10 patients were older than 60 years. Of the patients in Group A, 100% were taking a serotonin reuptake inhibitor (SRI). In Group B, 8.8% of patients were taking an SRI.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>All the patients who experienced transient neurological events were taking an SRI. A correlation can be made between methylene blue infusion and SRI usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>SIGNIFICANCE<\/jats:title><jats:p>Patients taking SRIs may represent a high\u2010risk group for postoperative neurological events when methylene blue is utilized.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.05.026","type":"journal-article","created":{"date-parts":[[2006,10,28]],"date-time":"2006-10-28T07:18:43Z","timestamp":1162019923000},"page":"765-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Toxic metabolic encephalopathy after parathyroidectomy with methylene blue localization"],"prefix":"10.1002","volume":"135","author":[{"given":"Swapna S.","family":"Kartha","sequence":"first","affiliation":[{"name":"University of Louisville School of Medicine Department of Surgery Division of Otolaryngology Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chacko E.","family":"Chris","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey M.","family":"Bumpous","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine Department of Surgery Division of Otolaryngology Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muffin","family":"Fleming","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine Department of Surgery Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric J.","family":"Lentsch","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine Department of Surgery Division of Otolaryngology Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael B.","family":"Flynn","sequence":"additional","affiliation":[{"name":"University of Louisville School of Medicine Department of Surgery Louisville Kentucky"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.3.5776.680"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(05)80850-5"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9610(98)00100-7"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005537-200111000-00005"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1072-7515(00)00297-0"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.137.9.1055"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1213\/01.ANE.0000134860.73875.CF"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2044.2003.03415_23.x"}],"container-title":["Otolaryngology\u2013Head and Neck Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.05.026","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.otohns.2006.05.026","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.otohns.2006.05.026","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T10:32:45Z","timestamp":1760956365000},"score":1,"resource":{"primary":{"URL":"https:\/\/aao-hnsfjournals.onlinelibrary.wiley.com\/doi\/10.1016\/j.otohns.2006.05.026"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1016\/j.otohns.2006.05.026"],"URL":"https:\/\/doi.org\/10.1016\/j.otohns.2006.05.026","archive":["Portico"],"relation":{},"ISSN":["0194-5998","1097-6817"],"issn-type":[{"value":"0194-5998","type":"print"},{"value":"1097-6817","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11]]},"assertion":[{"value":"2016-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}