{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:56Z","timestamp":1761007556273,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The present study was undertaken to investigate the expressions of glucocorticoid receptor\u2010\u03b1 (GR\u2010\u03b1) and \u2010\u03b2 (GR\u2010\u03b2) messenger RNA (mRNA) in normal parotid and adenoma tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Eighteen pleomorphic adenomas of the parotid gland and 12 parotid gland tissues adjacent to adenomas were studied by using real\u2010time fluorescent quantitative reverse\u2010transcription polymerase chain reaction method.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>The expression of both GR\u2010\u03b1 and GR\u2010\u03b2 mRNA in parotid adenoma were higher than that in normal parotid glands (<jats:italic>P<\/jats:italic> &lt; 0.001), the GR\u2010\u03b1\/GR\u2010\u03b2 ratios in parotid adenoma were lower than that in normal parotid glands (<jats:italic>P<\/jats:italic> &lt; 0.001), and there were no differences of both GR\u2010\u03b1 and GR\u2010\u03b2 mRNA as well as GR\u2010\u03b1\/GR\u2010\u03b2 ratios in male and female (<jats:italic>P<\/jats:italic> &gt; 0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION AND SIGNIFICANCE<\/jats:title><jats:p>Our results showed that the mRNA expression of both GR\u2010\u03b1 and GR\u2010\u03b2 were detectable in all studied specimens. The mRNA levels of these 2 GRs were higher, whereas the GR\u2010\u03b1\/GR\u2010\u03b2 ratios were lower in adenomas tissues than that in the parotid gland; no differences of these 2 GRs as well as GR\u2010\u03b1\/GR\u2010\u03b2 ratios were found between sexes. These data indicate that the relationship between the expressions of GRs and the clinical significance in parotid adenomas need further and profound investigation.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.05.035","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T09:44:54Z","timestamp":1164879894000},"page":"849-852","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Glucocorticoid receptor subunit gene expression in parotid gland and adenomas"],"prefix":"10.1002","volume":"135","author":[{"given":"Xiao\u2010Wen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology\u2010Head and Neck Surgery The Third Affiliated Hospital Sun Yat\u2010Sen University Guangdong PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of 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