{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T10:14:23Z","timestamp":1768472063046,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3424,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>The aim of this study was to investigate whether the recurrence interval influenced the survival of oral cavity squamous cell carcinoma patients after relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING<\/jats:title><jats:p>Retrospective charts were reviewed at a medical center.<\/jats:p><\/jats:sec><jats:sec><jats:title>METHODS<\/jats:title><jats:p>We retrospectively reviewed 1687 chart records of oral cancer patients. Statistical methods included descriptive statistics, bivariate analyses, Kaplan\u2010Meier survival analyses, and Cox proportional hazard models for investigating the relationship between the recurrence interval and survival of oral cancer patients after relapse.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Local recurrence rate was 31.3 percent. Kaplan\u2010Meier survival analyses showed the 5\u2010year overall survival after recurrence was 31.56 percent. Cox proportional hazard model revealed that those with recurrence interval less than 18\u00a0months tended to have a higher probability of death than those with recurrence interval greater than or equal to 18\u00a0months (relative risk, 1.743; 95% confidence interval, 1.298\u20132.358).<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>The interval from initial treatment to recurrence is an independent prognostic factor for oral squamous cell carcinoma patients. Those with a shorter disease\u2010free interval tend to have a less favorable outcome.<\/jats:p><jats:p>\u00a9 2007 American Academy of Otolaryngology\u2010Head and Neck Surgery Foundation. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.07.002","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T13:55:25Z","timestamp":1168350925000},"page":"112-118","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Impact of recurrence interval on survival of oral cavity squamous cell carcinoma patients after local relapse"],"prefix":"10.1002","volume":"136","author":[{"given":"Shih\u2010An","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Taichung Veterans General Hospital Taichung Taiwan"},{"name":"Department of Veterinary Medicine National Chung Hsing University Taichung Taiwan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong\u2010Kie","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillo\u2010facial Surgery Taichung Veterans General Hospital Taichung 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