{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:45:42Z","timestamp":1761007542837,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3455,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2006,12]]},"abstract":"<jats:sec><jats:title>OBJECTIVE:<\/jats:title><jats:p>To evaluate expression of cyclooxygenase (COX)\u20102 and 5\u2010lipoxygenase (5\u2010LO) associated with interleukin (IL)\u20104 promoter polymorphism \u2010590\u00a0in nasal polyp tissues.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN AND SETTING:<\/jats:title><jats:p>A prospective controlled study. A venous blood sample was taken to determine the genotype in 61\u00a0nasal polyp subjects. The C\u2010590T variant was determined by the polymerase chain reaction\u2010restriction fragment length polymorphism method. The expression of 5\u2010LO and COX\u20102 was determined with immunohistochemical staining in 37\u00a0nasal polyp tissues associated with genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS:<\/jats:title><jats:p>The genotype frequencies at position \u2010590 of the IL\u20104 gene in the patients with nasal polyp were C\/C (8.20%), C\/T (40.98%), and T\/T (50.82%). There was no significantly increased expression of COX\u20102 among genotypes. The 5\u2010LO expression was significantly increased in C\/C compared with C\/T and T\/T.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION:<\/jats:title><jats:p>We suggested that the IL\u20104 promoter polymorphism \u2010590\u00a0C\/C is associated with the expression of 5\u2010LO in the patients with nasal polyp.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.07.009","type":"journal-article","created":{"date-parts":[[2006,11,30]],"date-time":"2006-11-30T09:44:54Z","timestamp":1164879894000},"page":"928-932","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Expression of cyclooxygenase\u20102 and 5\u2010lipoxygenase in nasal polyps associated with interleukin\u20104 promoter polymorphism \u2010590"],"prefix":"10.1002","volume":"135","author":[{"given":"Seong","family":"Kook Park","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Inje University College of Medicine Pusan Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wook","family":"Heo Kyung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Inje University College of Medicine Pusan Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun","family":"Jung","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2010Head and Neck Surgery Inje University College of Medicine Pusan Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Su","family":"Yea","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Inje University College of Medicine Pusan Paik Hospital Busan Korea"},{"name":"Department of Biohealth Product Research Center Inje University College of Medicine Pusan Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"II","given":"Young","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Biohealth Product Research Center Inje University College of Medicine Pusan Paik Hospital Busan Korea"},{"name":"Department of Pathology Inje University College of Medicine Pusan Paik Hospital Busan Korea"},{"name":"Paik Institute for Clinical Research Inje University College of Medicine Pusan Paik Hospital Busan Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.immunol.17.1.701"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0198-8859(03)00173-3"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/16.13.4007"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.35.6.502"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.1995.tb00428.x"},{"key":"e_1_2_12_7_1","doi-asserted-by":"crossref","unstructured":"YeaSS YangYI ParkSK et al.Interleukin\u20104 C\u2010590T polymorphism is associated with protection against nasal polyps in a Korean population.Am J Rhinol. 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