{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T02:53:46Z","timestamp":1776999226016,"version":"3.51.4"},"reference-count":20,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3424,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:sec><jats:title>OBJECTIVE<\/jats:title><jats:p>Reduction of intraoperative bleeding is desirable to improve intraoperative visibility and to avoid complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>STUDY DESIGN<\/jats:title><jats:p>Prospective, controlled, randomized, double\u2010blinded study.<\/jats:p><\/jats:sec><jats:sec><jats:title>SETTING<\/jats:title><jats:p>Inclusion criteria were chronic rhinosinusitis with nasal polyps that involved all paranasal sinuses, Lund\u2010CT score \u2264 12, and double\u2010blind preoperative randomization of narcotics. Exclusion criteria included abnormal coagulation, perioperative blood pressure outside the range of 70 to 140\u00a0mmHg systolic and 50 to 90\u00a0mmHg diastolic and perioperative medication. Total blood loss (mL), blood loss per minute (mL\/min), platelet function, and parameter for endoscopic vision were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>RESULTS<\/jats:title><jats:p>Forty\u2010six patients (22 sedated with sevoflurane\/fentanyl, 24 sedated with propofol\/fentanyl) completed the study. Total blood loss (300.1 \u00b1 168.5\u00a0mL\/276.9 \u00b1 201.3\u00a0mL), blood loss per minute, and endoscopic vision showed no group difference. Platelet function was significantly impaired 45\u00a0minutes after onset of surgery in both groups, but more pronounced after propofol anesthesia.<\/jats:p><\/jats:sec><jats:sec><jats:title>CONCLUSION<\/jats:title><jats:p>Under conditions of balanced circulatory parameter, equal blood loss and endoscopic vision can be achieved with both tested anesthetic regimens. During extended operations demonstrated thrombocyte impairment by propofol may become clinically relevant.<\/jats:p><jats:p>\u00a9 2007 American Academy of Otolaryngology\u2013Head and Neck Surgery Foundation. All rights reserved.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.08.006","type":"journal-article","created":{"date-parts":[[2007,1,9]],"date-time":"2007-01-09T13:55:25Z","timestamp":1168350925000},"page":"45-50","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Propofol versus sevoflurane: Bleeding in endoscopic sinus surgery"],"prefix":"10.1002","volume":"136","author":[{"given":"Achim G.","family":"Beule","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University of Greifswald Greifswald Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frank","family":"Wilhelmi","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology\u2013Head and Neck Surgery University Hospital Regensburg Regensburg Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas 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