{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:27:03Z","timestamp":1761006423316,"version":"build-2065373602"},"reference-count":20,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3393,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>We investigated free radical scavenging activity and the possible neuroprotective effect of Tokishakuyakusan (TJ\u201023) on facial motor nucleus (FMN) motoneurons after peripheral axotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>In 40 adult rats, the right facial nerve was transected at the level of the stylomastoid foramen. Following axotomy, the effects of TJ\u201023 on nitric oxide synthase were investigated using NADPH\u2010d histochemistry. FMN motoneurons were counted bilaterally in sections stained with cresyl violet.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Rats administered TJ\u201023 exhibited clear suppression of injury\u2010induced neuronal NADPH\u2010d expression in the ipsilateral FMN when compared to nontreated controls. The number of surviving motoneurons in the ipsilateral FMN was significantly greater among TJ\u201023\u2010treated rats than nontreated controls on day 56 following axotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The present study demonstrates the neuroprotective effect of TJ\u201023 after peripheral facial nerve axotomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Significance<\/jats:title><jats:p>Antioxidants may have therapeutic potential in traumatic facial nerve dysfunction resulting from head injury, ear surgery, and parotid gland surgery.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.08.012","type":"journal-article","created":{"date-parts":[[2007,2,3]],"date-time":"2007-02-03T02:46:06Z","timestamp":1170470766000},"page":"225-230","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Neuroprotective effects of TJ\u201023 (Tokishakuyakusan) on adult rat motoneurons 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