{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T12:47:32Z","timestamp":1762865252719,"version":"build-2065373602"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2016,5,17]],"date-time":"2016-05-17T00:00:00Z","timestamp":1463443200000},"content-version":"vor","delay-in-days":3365,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["aao-hnsfjournals.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Otolaryngol.--head neck surg."],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:sec><jats:title>Objective<\/jats:title><jats:p>To test the susceptibility of <jats:italic>Streptococcus pneumoniae<\/jats:italic> sinus isolates collected across the United States against commonly used antimicrobial agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design and Setting<\/jats:title><jats:p><jats:italic>S. pneumoniae<\/jats:italic> sinus isolates (N = 847) collected as part of the Tracking Resistance in the US Today Surveillance Program from 2001 to 2005 were tested against 8 antimicrobial agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In ascending order, the relative activities (% susceptible) were penicillin (51.8%), trimethoprim\/sulfamethoxazole (TMP\/SMX) (57.6%), erythromycin (59.5%), cefuroxime (62.0%), amoxicillin\/clavulanate (85.5%), clindamycin (86.1%), levofloxacin (99.4%), and linezolid (100%; for 2004 and 2005 respiratory seasons, only). Resistance rates over the 5 years remained generally stable, although resistance to amoxicillin\/clavulanate nearly doubled (from 6.5% to 12.9%). Forty percent of isolates were resistant to \u22652 agents tested.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Significance<\/jats:title><jats:p>Susceptibility trends among sinus <jats:italic>S. pneumoniae<\/jats:italic> isolates appear to have stabilized over the past 5 years. Resistance rates remain elevated for penicillin and macrolides, whereas the high prevalence of multidrug resistance remains a concern.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.otohns.2006.09.016","type":"journal-article","created":{"date-parts":[[2007,2,26]],"date-time":"2007-02-26T10:43:42Z","timestamp":1172486622000},"page":"385-389","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Antimicrobial resistance trends among sinus isolates of Streptococcus pneumoniae in the United States (2001\u20132005)"],"prefix":"10.1002","volume":"136","author":[{"given":"Daniel F.","family":"Sahm","sequence":"first","affiliation":[{"name":"Eurofins Medinet Anti\u2010Infective Services, Inc Herndon VA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael S.","family":"Benninger","sequence":"additional","affiliation":[{"name":"Henry Ford Hospital Detroit MI"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.","family":"Evangelista","sequence":"additional","affiliation":[{"name":"Ortho\u2010McNeil, Inc Raritan NJ"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y. 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